Beta-Amino Acids
β-peptides and other β-amino acid containing oligomers have emerged as very promising tools in medicinal chemistry, as they often exhibit remarkable biological activity together with enhanced biological stability, especially towards common peptidases. Hybrid α- and β-oligopeptides have shown compatibility with native biological systems while still affording the advantages offered by β-amino acids. Another important aspect of β-peptide oligomers is their ability to fold into well defined and stable helical, turn and pleated sheet conformations in solution, oftentimes displaying a reverse orientation of their α-amino acid counterparts. Sigma-Aldrich offers a variety of β-amino acids, including those with Boc- and Fmoc- functionality, for β-peptide synthesis.

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Beta-Amino Acids and Homo Amino Acids

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59891 N-Acetyl-DL-β-phenylalanine ≥97.0% (HPLC) C11H13NO3
    • 146064 β-Alanine 99% C3H7NO2
    • 05160 β-Alanine BioXtra, ≥99.0% (NT) C3H7NO2
    • 306142 β-Alanine ethyl ester hydrochloride 98% C5H11NO2 · HCl
    • 05210 β-Alanine methyl ester hydrochloride ≥98.0% (AT) C4H9NO2 · HCl
    • 573450 3-Amino-3-(3-bromophenyl)propionic acid 97% C9H10BrNO2
    • A44207 3-Aminobutanoic acid 97% C4H9NO2
    • 217794 DL-3-Aminoisobutyric acid 98% C4H9NO2
    • 15382 Boc-β-Ala-OH ≥99.0% (TLC) C8H15NO4
    • 80393 cis-3-(Boc-amino)cyclohexanecarboxylic acid ≥98.0% (TLC) C12H21NO4
    • 09784 (1S,3R)-(+)-3-(Boc-amino)cyclopentanecarboxylic acid ≥96.0% (HPLC) C11H19NO4
    • 15058 (2R,3R)-3-(Boc-amino)-2-hydroxy-4-phenylbutyric acid ≥98.0% C15H21NO5
    • 670758 2-(Boc-aminomethyl)phenylacetic acid ≥99.0% C14H19NO4
    • 78953 (R)-3-(Boc-amino)-2-methylpropionic acid ≥98.0% (TLC) C9H17NO4
    • 40195 (S)-3-(Boc-amino)-2-methylpropionic acid ≥98.0% (TLC) C9H17NO4
    • 73300 (R)-3-(Boc-amino)-4-(2-naphthyl)butyric acid ≥98.0% (HPLC) C19H23NO4
    • 78018 (R)-3-(Boc-amino)-5-phenylpentanoic acid ≥97.0% (HPLC) C16H23NO4
    • 74037 (R)-Boc-4-bromo-β-Phe-OH ≥98.0% (HPLC) C14H18BrNO4
    • 93123 (S)-Boc-4-bromo-β-Phe-OH ≥98.0% (HPLC) C14H18BrNO4
    • 81771 (S)-Boc-4-chloro-β-Homophe-OH ≥98.0% (HPLC) C15H20ClNO4
    • 61902 (R)-Boc-4-chloro-β-Phe-OH ≥98.0% (HPLC) C14H18ClNO4
    • 19343 (S)-Boc-4-chloro-β-Phe-OH ≥98.0% (HPLC) C14H18ClNO4
    • 91919 (S)-Boc-2-cyano-β-Homophe-OH ≥98.0% (HPLC) C16H20N2O4
    • 90368 (R)-Boc-4-cyano-β-Homophe-OH ≥98.0% (HPLC) C16H20N2O4
    • 81834 (S)-Boc-4-cyano-β-Homophe-OH ≥98.0% (HPLC) C16H20N2O4
    • 12339 (R)-Boc-4-cyano-β-Phe-OH ≥98.0% (HPLC) C15H18N2O4
    • 44376 (S)-Boc-4-cyano-β-Phe-OH ≥98.0% C15H18N2O4
    • 08009 (R)-Boc-3,4-dimethoxy-β-Phe-OH ≥98.0% C16H23NO6
    • 04542 (S)-Boc-3,4-dimethoxy-β-Phe-OH ≥98.0% (HPLC) C16H23NO6
    • 82007 (S)-Boc-γ,γ-diphenyl-β-Homoala-OH ≥98.0% (HPLC) C21H25NO4
    • 51006 (R)-Boc-4-fluoro-β-Phe-OH ≥98.0% (HPLC) C14H18FNO4
    • 05102 (S)-Boc-4-fluoro-β-Phe-OH ≥98.0% (HPLC) C14H18FNO4
    • 03651 Boc-β-Gln-OH ≥98.0% (TLC) C10H18N2O5
    • 03691 Boc-β-Glu(OBzl)-OH ≥98.0% (HPLC) C17H23NO6
    • 14974 Boc-β-Homoala-OH ≥98.0% (TLC) C9H17NO4
    • 03674 Boc-β-Homoarg(Tos)-OH ≥98.0% (TLC) C19H30N4O6S
    • 03667 Boc-β-Homogln-OH ≥98.0% (TLC) C11H20N2O5
    • 03683 Boc-β-Homohyp(Bzl)-OH (dicyclohexylammonium) salt technical, ≥85% (HPLC) C18H25NO5 · C12H23N
    • 14975 Boc-β-Homoleu-OH ≥98.0% (TLC) C12H23NO4
    • 14978 Boc-β-Homolys(Z)-OH ≥98.0% (TLC) C20H30N2O6
    • 03661 Boc-β-Homomet-OH ≥98.0% (TLC) C11H21NO4S
    • 14979 Boc-β-Homophe-OH ≥98.0% (TLC) C15H21NO4
    • 14982 Boc-β3-Homopro-OH ≥98.0% (TLC) C11H19NO4
    • 14976 Boc-β-Homothr(Bzl)-OH ≥98.0% (TLC) C17H25NO5
    • 14981 Boc-β-Homotrp-OH ≥98.0% (TLC) C17H22N2O4
    • 03693 Boc-β-Homotyr(Bzl)-OH ≥97.0% (HPLC) C22H27NO5
    • 03678 Boc-β-Leu-OH ≥98.0% (TLC) C11H21NO4
    • 52169 (R)-Boc-3-methoxy-β-Phe-OH ≥98.0% (HPLC) C15H21NO5
    • 55894 (S)-Boc-3-methoxy-β-Phe-OH ≥98.0% (HPLC) C15H21NO5
    • 56999 (R)-Boc-4-methoxy-β-Phe-OH ≥98.0% (HPLC) C15H21NO5
    • 06731 (R)-Boc-2-methyl-β-Phe-OH ≥98.0% C15H21NO4
    • 06939 (S)-Boc-2-methyl-β-Phe-OH ≥98.0% (HPLC) C15H21NO4
    • 42722 (R)-Boc-3-methyl-β-Phe-OH ≥98.0% (HPLC) C15H21NO4
    • 90297 (R)-Boc-4-methyl-β-Phe-OH ≥98.0% (HPLC) C15H21NO4
    • 90298 (S)-Boc-4-methyl-β-Phe-OH ≥98.0% (HPLC) C15H21NO4
    • 09794 Boc-β-Phe-OH ≥96.0% (HPLC) C14H19NO4
    • 09793 Boc-D-β-Phe-OH ≥98.0% (HPLC) C14H19NO4
    • 95336 (R)-Boc-4-(4-pyridyl)-β-Homoala-OH ≥98.0% (HPLC) C14H20N2O4
    • 93647 (S)-Boc-4-(4-pyridyl)-β-Homoala-OH ≥97.0% (HPLC) C14H20N2O4
    • 87943 (S)-Boc-2-(trifluoromethyl)-β-Homophe-OH ≥98.0% (HPLC) C16H20F3NO4
    • 81998 (S)-Boc-2-(trifluoromethyl)-β-Homophe-OH ≥98.0% (HPLC) C16H20F3NO4
    • 55685 (S)-Boc-2-(trifluoromethyl)-β-Phe-OH ≥98.0% C15H18F3NO4
    • 18328 (R)-Boc-3-(trifluoromethyl)-β-Phe-OH ≥95.0% (HPLC) C15H18F3NO4
    • 73999 (R)-Boc-4-(trifluoromethyl)-β-Phe-OH ≥98.0% (HPLC) C15H18F3NO4
    • 89090 (R)-Boc-β-Tyr-OH ≥97.0% (HPLC) C14H19NO5
    • 56996 (S)-Boc-β-Tyr-OH ≥98.0% (HPLC) C14H19NO5
    • 700959 Ethyl 3-(benzylamino)propionate 97% C12H17NO2
    • 47587 Fmoc-β-Ala-OH ≥99.0% (HPLC) C18H17NO4
    • 30975 (R)-3-(Fmoc-amino)-2-methylpropionic acid ≥95.0% (HPLC) C19H19NO4
    • 38811 (S)-3-(Fmoc-amino)-2-methylpropionic acid ≥95.0% C19H19NO4
    • 70796 (R)-3-(Fmoc-amino)-4-(2-naphthyl)butyric acid ≥95.0% C29H25NO4
    • 88574 (S)-Fmoc-3,4-difluoro-β-Homophe-OH ≥98.0% C25H21F2NO4
    • 89846 (S)-Fmoc-γ,γ-diphenyl-β-Homoala-OH ≥98.0% (HPLC) C31H27NO4
    • 03689 Fmoc-β-Glu(OtBu)-OH ≥95.0% (HPLC) C24H27NO6
    • 47935 Fmoc-β-Homoala-OH ≥98.0% (HPLC) C19H19NO4
    • 03673 Fmoc-β-Homoarg(Pmc)-OH ≥95.0% (HPLC) C36H44N4O7S
    • 64179 Fmoc-β-Homogln(Trt)-OH ≥95.0% (HPLC) C40H36N2O5
    • 03751 Fmoc-β-Homohyp(tBu)-OH ≥98.0% C25H29NO5
    • 03671 Fmoc-β-Homoile-OH ≥96.0% (HPLC) C22H25NO4
    • 47946 Fmoc-β-Homoleu-OH ≥96.0% C22H25NO4
    • 47874 Fmoc-β-Homolys(Boc)-OH ≥95.0% (HPLC) C27H34N2O6
    • 03658 Fmoc-β-Homomet-OH ≥97.0% (HPLC) C21H23NO4S
    • 47912 Fmoc-L-β3-homoproline ≥98.0% (HPLC) C21H21NO4
    • 47911 Fmoc-β-Homothr(tBu)-OH ≥96.0% (HPLC) C24H29NO5
    • 47901 Fmoc-β-Homotrp-OH ≥96.0% (HPLC) C27H24N2O4
    • 03692 Fmoc-β-Homotyr(tBu)-OH ≥98.0% C29H31NO5
    • 85497 (S)-Fmoc-2-methyl-β-Homophe-OH ≥98.0% (HPLC) C26H25NO4
    • 80587 (S)-Fmoc-3-methyl-β-Homophe-OH ≥98.0% (HPLC) C26H25NO4
    • 09795 Fmoc-β-Phe-OH ≥98.0% C24H21NO4
    • 00396 Fmoc-β-D-Phe-OH ≥98.0% (HPLC) C24H21NO4
    • 73309 (R)-Fmoc-4-(3-pyridyl)-β-Homoala-OH ≥98.0% (HPLC) C24H22N2O4
    • 03698 L-β-Homohydroxyproline hydrochloride ≥98.0% (TLC) C6H11NO3 · HCl
    • 03764 L-β-Homoleucine hydrochloride ≥98.0% C7H15NO2 · HCl
    • 21625 DL-β-Homoleucine ≥99.0% (NT) C7H15NO2
    • 03759 L-β-Homolysine dihydrochloride ≥98.0% (TLC) C7H16N2O2 · 2HCl
    • 03681 L-β-Homomethionine hydrochloride ≥98.0% (TLC) C6H13NO2S · HCl
    • 03769 L-β-Homophenylalanine hydrochloride ≥98.0% C10H13NO2 · HCl
    • 28217 DL-β-Homophenylalanine ≥98.0% (HPLC) C10H13NO2
    • 03768 ′L-β-Homoproline′ hydrochloride ≥98.0% (TLC) C6H11NO2 · HCl
    • 03694 L-β-Homoserine ≥98.0% (TLC) C4H9NO3
    • 03767 L-β-Homothreonine ≥98.0% (TLC) C5H11NO3
    • 03675 L-β-Leucine hydrochloride ≥98.0% C6H13NO2 · HCl
    • 159492 DL-β-Phenylalanine 98% C9H11NO2
    • 670774 (R)-(−)-Pyrrolidine-3-carboxylic acid ≥99.0% (NT) C5H9NO2
    • 670871 (S)-(+)-Pyrrolidine-3-carboxylic acid ≥98.0% (NT) C5H9NO2
    • 17974 Z-β-Dab(Boc)-OH ≥98.0% (TLC) C17H24N2O6
    • 61669 Z-β-Homoala-OH ≥98.0% (HPLC) C12H15NO4
    • 76024 Z-β-Homotrp(Boc)-OH ≥97.0% (HPLC) C25H28N2O6