Resins for Fmoc-/tBu-SPPS

Solid-Phase Peptide Synthesis

Sigma-Aldrich offers an extensive line of polymer supports for Fmoc-based solid phase peptide synthesis (Merrifield SPPS), including TFA-labile Wang resin, HypoGel®, Rink, and Tentagel S PHB Resins in a variety of mesh sizes and preloaded forms.

Tentagel S PHB resins preloaded with N-α-Fmoc-protected amino acids are excellent acid-labile supports for Fmoc-/tBu SPPS of peptide acids. Due to the unique properties of the Tentagel resin, synthesis can be performed both in a batch and in a continuous-flow system. The Fmoc-amino acids are coupled to the Tentagel S PHB resin in such a way that epimerization and dipeptide formation are minimized. Our preloaded Tentagel S PHB resins are high-quality supports, which enable you to start directly with the automated protocols. The polymer matrix of Tentagel S PHB is PEG grafted on low cross-linked PS beads.

Learn More about Resins for Fmoc-/tBu SPPS
Resins for the Fmoc-/tBu-Synthesis of Peptide Acids
Tentagel S PHB Resins Preloaded with N-α-Fmoc-Protected Amino Acids