Designer Surfactants

Designer surfactants have been developed to make Green Chemistry readily available to synthetic chemists through micellar catalysis, allowing common reactions to be run in water instead of organic solvent. This technology is enabled by the water-promoted aggregation of amphiphiles into nanomicelles, which surround water-insoluble organic substrates and provide a facile environment for reactions. Now that many of the most synthetically useful transformations can be performed in aqueous conditions, the scientific community can better contribute to Green Chemistry efforts and the reduction of organic solvent waste. In collaboration with the Lipshutz Research Group, Aldrich Chemistry is proud to offer designer surfactants for myriad organic reactions.

Designer Surfactants

Amphiphiles particularly developed to assist transition metal-catalyzed cross-coupling reactions at room temperature and in water

  • PTS Vitamin E core linked to PEG arm through sebacate; forms micelles in the shapes of both rods and spheres
  • TPGS-750-M PTS derivative with shorter, succinic acid linker and longer PEG for greater lipophilic-hydrophilic balance; generates spherical particles
  • Nok Phytosterol core that is PEGylated through a succinic acid linker; forms worm-like micelles

All-in-One Kits Complete with TPGS-750-M

Aldrich Chemistry and the Lipshutz Research Group have developed the next generation of kits containing the designer surfactant TPGS-750-M. These all-in-one boxed reactions enable transition metal-catalyzed cross-coupling reactions to be run at room temperature. These single-use kits facilitate simple setup of commonly used reactions and come with premeasured catalysts, surfactant, and additives, as well as written protocols for guidance.

Find out more about these kits and their protocols in our Technology Spotlight: Second-Generation, Designer-Surfactant Kits: Aqueous Reactions in a Box