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Stable Isotopes

Stable Isotopes in Biomolecular NMR


An important tool for high-resolution structure determination by NMR spectroscopy is the use of stable isotope labeled biomolecules. By either selectively or uniformly incorporating stable isotopes into proteins, investigators can reduce the complexity of their spectra significantly. 13C, 15N, and deuterium are the most common isotopes incorporated into proteins through microbial expression systems, with cell-free extracts or through peptide synthesis.

We offer isotopically-labeled carbohydrates, amino acids, nutrients, and media components for use in expression systems, as well as formulated growth media, such as ISOGRO™ and IsoYeast.