Nucleotides

Stable Isotope Labeled Nucleic Acids for Biomolecular NMR

Advancements in NMR methodology, increased availability of larger, more powerful NMR instrumentation and the availability of stable isotope labeled nucleic acids have made the structure and function elucidation of nucleotide macromolecules a genuine reality. The use of labeled nucleic acids helps to overcome challenges such as extensive spectral crowding, increased resonance linewidths, and overall NMR signal degeneracy by providing the ability to enhance experimental sensitivity and spectral resolution. These enhancements help to increase the accuracy of solution structure determinations by facilitating the measurements of local and long-range distance restraints. 13C and/or 15N labeled nucleic acids have been employed to study the links between RNA secondary structure and global conformation as well as determine dynamics in DNA flexibility.

ISOTEC Stable Isotopes offers an extensive array of 13C, 15N, and D labeled nucleic acids. Our NTPs and NMPs are supplied as sodium salt powders or are suspended in 5 mM Tris HCl buffer.

Literature:
Products for Nucleic Acid Research

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Deoxyribonucleotide monophosphates

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900386 2′-Deoxyadenosine-13C10,15N5 5′-monophosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
648620 2′-Deoxyadenosine-13C10,15N5 5′-monophosphate disodium salt ≥98 atom %, ≥95% (CP)
648612 2′-Deoxycytidine-13C9,15N3 5′-monophosphate disodium salt ≥98 atom %, ≥95% (CP)
900383 2′-Deoxycytidine-13C9,15N3 5′-monophosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
648604 2′-Deoxyguanosine-13C10,15N5 5′-monophosphate disodium salt ≥98 atom %, ≥95% (CP)
900384 2′-Deoxyguanosine-13C10,15N5 5′-monophosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
648590 Thymidine-13C10, 15N2 5′-monophosphate disodium salt ≥98 atom %, ≥95% (CP)
900385 Thymidine-13C10,15N2 5′-monophosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)

Deoxyribonucleotide triphosphates

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646237 2′-Deoxyadenosine-13C10,15N5 5′-triphosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
646229 2′-Deoxycytidine-13C9,15N3 5′-triphosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
646210 2′-Deoxyguanosine-13C10,15N5 5′-triphosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
646202 Thymidine-13C10,15N2 5′-triphosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)

Ribonucleotide monophosphates

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662658 Adenosine-15N5 5′-monophosphate disodium salt ≥98 atom % 15N, ≥95% (CP)
650676 Adenosine-13C10,15N5 5′-monophosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
900382 Adenosine-15N5 5′-monophosphate disodium salt solution ≥98 atom % 15N, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
662682 Cytidine-15N3 5′-monophosphate disodium salt ≥98 atom % 15N, ≥95% (CP)
900379 Cytidine-15N3 5′-monophosphate disodium salt solution ≥98 atom % 15N, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
650692 Cytidine-13C9,15N3 5′-monophosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
662674 Guanosine-15N5 5′-monophosphate disodium salt ≥98 atom % 15N, ≥95% (CP)
900380 Guanosine-15N5 5′-monophosphate disodium salt solution ≥98 atom % 15N, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
760161 Guanosine-13C10,15N5 3′,5′-cyclic monophosphate calcium salt 99 atom % 13C, 98 atom % 15N, 95% (CP)
650684 Guanosine-13C10,15N5 5′-monophosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
662666 Uridine-15N2 5′-monophosphate disodium salt ≥98 atom % 15N, ≥95% (CP)
900381 Uridine-15N2 5′-monophosphate disodium salt solution ≥98 atom % 15N, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
651370 Uridine-13C9,15N2 5′-monophosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)

Ribonucleotide triphosphates

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707783 Adenosine-15N5 5′-triphosphate disodium salt solution ≥98 atom % 15N, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
710695 Adenosine-13C10 5′-triphosphate disodium salt solution ≥98 atom % 13C, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
645702 Adenosine-13C10,15N5 5′-triphosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
902411 Adenosine-d14 5′-triphosphate disodium salt solution ≥98 atom % D, ≥95% (CP), 100 mM (in 5mM Tris / D2O)
707759 Cytidine-15N3 5′-triphosphate disodium salt solution ≥98 atom % 15N, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
645699 Cytidine-13C9,15N3 5′-triphosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
711020 Cytidine-13C9 5′-triphosphate disodium salt solution ≥98 atom % 13C, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
902438 Cytidine-d14 5′-triphosphate disodium salt solution ≥98 atom % D, ≥95% (CP), 100 mM (in 5mM Tris / D2O)
707775 Guanosine-15N5 5′-triphosphate disodium salt solution ≥98 atom % 15N, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
710687 Guanosine-13C10 5′-triphosphate disodium salt solution ≥98 atom % 13C, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
645680 Guanosine-13C10,15N5 5′-triphosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
902446 Guanosine-d14 5′-triphosphate disodium salt solution ≥98 atom % D, ≥95% (CP), 100 mM (in 5mM Tris / D2O)
707767 Uridine-15N2 5′-triphosphate disodium salt solution ≥98 atom % 15N, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
711012 Uridine-13C9 5′-triphosphate disodium salt solution ≥98 atom % 13C, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
645672 Uridine-13C9,15N2 5′-triphosphate disodium salt solution ≥98 atom %, ≥95% (CP), 100 mM (in 5mM Tris HCl / H2O)
902454 Uridine-d13 5′-triphosphate disodium salt solution ≥98 atom % D, ≥95% (CP), 100 mM (in 5mM Tris / D2O)