Steroids and Hormones

Stable Isotope Labeled Steroids and Hormones

Steroids and hormones make up a complex group of bioactive compounds due to their therapeutic utility, their role in metabolic processes, their intricate reactivity profile and structural similarities. The same properties that raise interest in these biologically relevant molecules, however, are also those that make their study intensely challenging. The use of stable isotope labeled steroids and hormones has alleviated some of the difficulties surrounding identification, differentiation and analysis of these compounds.

The labeled compounds shown below have been useful in a broad range of research topics, with an emphasis being applied to improving methods for identification, quantification and mixture analysis. Some of the interesting and important topics to be researched include environmental contamination due to hormone excretion,1 the quantification of therapeutic agents such as corticosteroids2 and identification of biomarkers for liver and intestinal disorders, dehydration and stress.3

Isotec Stable Isotopes stocks nearly 50 different steroids and hormones which are available with 13C and/or deuterium labels. This group includes not only steroids and hormones, but also labeled precursors and metabolites. The variety of compounds offered coupled to the convenient quantities available adds to the utility of these products.


References
1) a) Duong, C.N.; Ra, J.S.; Schlenk, D.; Kim, S.D.; Choi, H.K.; Kim, S.D.; Arch. Environ, Contam. Toxicol. 2010, 59, 147-156. b) Rice, S.L.; Hale, R.C.; Anal. Chem. 2009, 81, 6716-6724.
2) Ionita, I.A.; Fast, D.M.; Akhlaghi, F.; J. Chrom. B, 2009, 877, 765-772.
3) a) Taylor, P.J.; van Rosendal, S.P.; Coombes, J.S.; Gordon, R.D.; Stowasser, M.; J. Chrom. B. 2010, 878, 1195-1198. b) Taylor, P.J.; Cooper, D.P.; Gordon, R.D.; Stowasser, M.; Clin. Chem. 2009, 55, 1155-1162. c) Soldin, O.P.; Sharma, H.; Husted, L.; Soldin, S.J.; Clin. Biochem. 2009, 42, 823-827. d) Guo, T.; Taylor, R.L.; Singh, R.J.; Soldin, S.J.; Clin. Chim. Acta, 2006, 372, 76-82. e) Burkard, I.; von Eckardstein, A.; Rentsch, K.M.; J. Chrom. B, 2005, 826, 147-159.

Technical Article
Stable Isotope Labeled Standards: Steroids

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706035 Aldosterone-2,2,4,6,6,21,21-d7 ≥98 atom % D (based on d7), ≥98% (CP)
802883 Aldosterone-9,11,12,12-d4 solution 100 μg/mL in acetonitrile, ≥98 atom % D, ≥97% (CP)
809853 Allopregnanolone-2,2,3,4,4-d5 solution 100 μg/mL in methanol, ≥98 atom % D, ≥98% (CP)
730645 4-Androstene-3,17-dione-2,3,4-13C3 solution 0.1 mg/mL in methanol, 98 atom % 13C, 98% (CP)
747505 5α-Cholestane-2,2,4,4-d4 98 atom % D, 97% (CP)
777900 5α-Cholestan-3β-ol-2,2,3,4,4-d5 98 atom % D, 97% (CP)
488577 Cholesterol-2,2,3,4,4,6-d6 97 atom % D, 98% (CP)
749478 Cholesterol-2,3,4-13C3 99 atom % 13C, 98% (CP)
488585 Cholesterol-3,4-13C2 99 atom % 13C
662291 Cholesterol-3,4-13C2 S & P tested, 99 atom % 13C
605875 Cholesterol-4-13C 99 atom % 13C
809837 Cholesterol-23,24,25,26,27-13C5 ≥99 atom % 13C, ≥98% (CP)
677574 Cholesterol-25,26,26,26,27,27,27-d7 99 atom % D, 98% (CP)
707678 Cholesterol-25,26,27-13C3 99 atom % 13C, 99% (CP)
679046 Cholesterol-26,26,26,27,27,27-d6 98 atom % D, 97% (CP)
802905 Corticosterone-9,11,12,12-d4 98 atom % D, 97% (CP)
900170 Cortisone-2,2,4,6,6,9,12,12-d8 ≥98 atom % D, ≥98% (CP)
803154 Cortisone-2,3,4-13C3 solution 100 μg/mL in methanol, 98 atom % 13C, 97% (CP)
900079 Cortisone-2,3,4-13C3 21-sulfate sodium salt solution 100 μg/mL in methanol, ≥98 atom % 13C, ≥95% (CP)
774898 7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 ≥99 atom % D, ≥98% (CP)
809640 Dehydroepiandrosterone-2,2,3,4,4-d5 ≥98 atom % D, ≥97% (CP)
709549 Dehydroepiandrosterone-2,2,3,4,4,6-d6 97 atom % D, 98% (CP)
723266 Dehydroepiandrosterone-2,2,3,4,4,6-d6 sulfate sodium salt 97 atom % D, 98% (CP)
809586 11-Deoxycorticosterone-2,3,4-13C3 solution 100 μg/mL in methanol, ≥99 atom % 13C, ≥98% (CP)
710784 11-Deoxycortisol-2,2,4,6,6-d5 98 atom % D, 98% (CP)
809594 11-Deoxycortisol-2,3,4-13C3 solution 100 μg/mL in methanol, ≥98 atom % 13C, ≥97% (CP)
730637 Dihydrotestosterone-2,3,4-13C3 solution 0.1 mg/mL in methanol, 99 atom % 13C, 97% (CP)
719528 3, 3′-Diiodo-L-thyronine-(phenoxy-13C6) (T2) 99 atom % 13C, 97% (CP)
719536 3,3′-Diiodo-L-thyronine (T2) 98% (CP)
771775 (±)-Epinephrine-(N-methyl-d3) 98 atom % D, 98% (CP)
492523 Equilin-2,4,16,16-d4 98 atom % D
E4260 β-Estradiol-d2 98 atom % D
719552 17β-Estradiol-2,3,4-13C3 99 atom % 13C, 98% (CP)
613967 17β-Estradiol-2,4,16,16,17-d5 97 atom % D, 99% (CP)
491187 17β-Estradiol-16,16,17-d3 98 atom % D, 99% (CP)
731668 Estriol-2,3,4-13C3 99 atom % 13C, 97% (CP)
719544 Estrone-2,3,4-13C3 99 atom % 13C, 98% (CP)
802921 Estrone-2,3,4-13C3 solution 100 μg/mL in methanol, 99 atom % 13C, 98% (CP)
489204 Estrone-2,4,16,16-d4 95 atom % D
524956 Estrone-2,4,16,16-d4 3-sulfate sodium salt ≥95 atom % D, ≥99% (CP), contains 35% TRIS-d5 as stabilizer
809861 Etiocholanolone-2,2,3,4,4-d5 solution 100 μg/mL in methanol, ≥98 atom % D, ≥98% (CP)
739723 Glycocholic-2,2,4,4-d4 acid 98 atom % D, 98% (CP)
605891 Glycocholic acid-(glycyl-1-13C) ≥99 atom % 13C, ≥98 (CP)
337609 Glycocholic acid-(glycyl-1-13C) monohydrate 99 atom % 13C
739707 Glycodeoxycholic-2,2,4,4-d4 acid ≥98 atom % D, ≥98% (CP)
614157 Hydrocortisone-1α,2α-d2 98 atom % D
803146 Hydrocortisone-2,3,4-13C3 solution 100 μg/mL in methanol, 99 atom % 13C, 98% (CP)
705594 Hydrocortisone-9,11,12,12-d4 98 atom % D, 98% (CP)
900080 Hydrocortisone-9,11,12,12-d4 21-sulfate sodium salt ≥99 atom % D, ≥98% (CP)
710806 18-Hydroxycorticosterone 97% (CP)
710792 18-Hydroxycorticosterone-9,11,12,12-d4 ≥98 atom % D, ≥95% (CP)
731641 16-α-Hydroxyestrone-2,3,4-13C3 99 atom % 13C, 98% (CP)
803081 17α-Hydroxypregnenolone-20,21-13C2,16,16-d2 ≥98 atom %, ≥98% (CP)
738093 17α-Hydroxyprogesterone-2,3,4-13C3 98 atom % 13C, 98% (CP)
615609 Indole-2,4,5,6,7-d5-3-acetic-2,2-d2 acid 97 atom % D
492817 Indole-3-acetic-2,2-d2 acid 98 atom % D, 98% (CP)
793485 Melengestrol acetate-d3 98 atom % D, 98% (CP)
705829 2-Methoxy-13C,d3-estradiol ≥98 atom %, ≥98% (CP)
614076 2-Methoxy-17β-estradiol-1,4,16,16,17-d5 98 atom % D
705713 4-Methoxy-13C,d3-estradiol 98 atom % D, 98 atom % 13C, 98% (CP)
705705 2-Methoxy-13C,d3-estrone 98 atom % D, 99 atom % 13C, 98% (CP)
705691 4-Methoxy-13C,d3-estrone 99 atom % 13C, 98 atom % D, 98% (CP)
900169 Oxytocin-(leucine-5,5,5-d3, glycine-2,2-d2) trifluoroacetate salt ≥98 atom % D, ≥95% (CP)
809845 Pregnenolone-2,2,4,4-d4 ≥98 atom % D, ≥95% (CP)
739545 Pregnenolone-20,21-13C2-16,16-d2 98 atom % D, 98 atom % 13C, 98% (CP)
740985 Pregnenolone-20,21-13C2-16,16-d2 sulfate sodium salt 98 atom % D, 98 atom % 13C, 98% (CP)
672904 Progesterone-2,2,4,6,6,17α,21,21,21-d9 98 atom % D, 98% (CP)
737143 Progesterone-2,3,4-13C3 99 atom % 13C, 98% (CP)
803065 Progesterone-2,3,4-13C3 solution 100 μg/mL in acetonitrile, 99 atom % 13C, 98% (CP)
680028 Sitostanol-5,6,22,23-d4 97 atom % D, 95% (CP)
721301 Sodium pregnenolone-17A, 21,21,21-d4 sulfate sodium salt 98 atom % D, 98% (CP)
730610 Testosterone-2,3,4-13C3 solution 0.1 mg/mL in methanol, 99 atom % 13C, 98% (CP)
750026 3α,5β-Tetrahydroaldosterone
900182 Tetrahydrocortisol-2,2,3,4,4-d5 ≥98 atom % D, ≥98% (CP)
809314 Tetrahydrocortisol-2,2,3,4,4-d5 solution 100 μg/mL in methanol, ≥98 atom % D, ≥98% (CP)
900183 Tetrahydrocortisone-2,2,3,4,4-d5 ≥98 atom % D, ≥98% (CP)
809276 Tetrahydrocortisone-2,2,3,4,4-d5 solution 100 μg/mL in methanol, ≥98 atom % D, ≥98% (CP)
695971 Tetrahydrocortisone-9,12,12,21,21-d5 98 atom % D
900067 L-Thyroxine-1",1",2,2",6-d5 hydrochloride solution ≥98 atom % D, ≥98% (CP), 100 μg/mL in methanol, contains 0.1 N NH3
699594 L-Thyroxine-(diphenyl-13C12) 99 atom % 13C, 97% (CP)
709719 3,3′,5′-Triiodothyronine-(diiodophenyl-13C6) hydrochloride 99 atom % 13C, 95% (CP)
709611 3,3′,5-Triiodothyronine-(tyrosine phenyl-13C6) hydrochloride 99 atom % 13C, 95% (CP)