Labeled Amino Acids

for Metabolic Research

Many amino acids are essential during some point of life. They are functionally diverse, serving as building blocks in protein, peptide and amino acid syntheses and playing crucial roles in pathways such as energy metabolism. The use of stable isotope labeled amino acids within metabolic research allows the analytical tracking of the amino acid or of a correspondingly labeled down field metabolite. The pathway and metabolite under study depend on both the amino acid and the labeling pattern. This specificity allows the researcher to take advantage of differences in overlapping pathways, which is not possible with natural abundance amino acids. Due to the versatility, researchers have used stable isotope labeled amino acids to study and verify nutritional requirements,1 to measure muscle protein synthesis,2 and for the confirmation of metabolic pathways such as amino acid synthesis.3

The stable isotope labeled amino acid selection offered by Isotec Stable Isotopes includes all the standard amino acids in varying labeling patterns as well as several other metabolically interesting amino acids. For the majority of the amino acids offered, S&P (sterility and pyrogen) tested material is routinely available and for all others, S&P testing can be requested.

1. a) Chapman, K.P.; Courtney-Martin, G.; Moore, A.M.; Langer, J.C.; Tomlinson, C.; Ball, R.O.; Pencharz, P.B.; Am. J. Clin. Nutr. 2010, 91, 958. b) Courtney-Martin, G.; Moore, A.M.; Ball, R.O.; Pencharz, P.B.; Pediatric Res. 2010, 67, 320.
2. a) Symons, T.B.; Sheffield-Moore, M.; Wolfe, R.R.; Paddon-Jones, D.; J. Am. Diet. Assoc. 2009, 109, 1582. b) Doessing, S.; Heinemeier, K.M.; Holm, L.; Mackey, A.L.; Schjerling, P.; Rennie, M.; Smith, K.; Reitelseder, S.; Kappelgaard, A.-M.; Rasmussen, M.;H.; Flyvbjerg, A.; Kjar, M.; J. Physiol. 2010, 588, 341. 3. Tomlinson, C.; Rafii, M.; Sgro, M.; Ball, R. O.; Pencharz, P.; Pediatric Res. 2011, 69, 46.

Product #

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489867 L-Alanine-1-13C 99 atom % 13C  
486779 L-Alanine-2-13C 99 atom % 13C  
604682 L-Alanine-2,3-13C2 99 atom % 13C, 99% (CP)  
485845 L-Alanine-2,3,3,3-d4 98 atom % D  
488917 DL-Alanine-2,3,3,3-d4 98 atom % D  
489875 L-Alanine-13C3 98 atom % 13C, 95% (CP)  
660760 L-Alanine-13C3 S & P tested, 99 atom % 13C S & P tested
489948 L-Alanine-3-13C 99 atom % 13C  
661511 L-Alanine-3-13C S & P tested, 99 atom % 13C S & P tested
489921 L-Alanine-3,3,3-d3 99 atom % D  
774820 L-Alanine-d7 98 atom % D, 98% (CP)  
332127 L-Alanine-15N 98 atom % 15N  
660787 L-Alanine-15N 98 atom % 15N, S & P tested S & P tested
711055 L-Arginine-1,2-13C2 hydrochloride 99 atom % 13C  
600113 L-Arginine-15N4 hydrochloride 98 atom % 15N, 97% (CP)  
609080 L-Arginine-(guanidineimino-15N2) hydrochloride 98 atom % 15N, 98% (CP)  
750824 L-Asparagine-1-13C 99 atom % 13C, 98% (CP)  
641960 L-Asparagine-15N2 98 atom % 15N, 98% (CP)  
485918 L-Asparagine-15N2 monohydrate 98 atom % 15N, 98% (CP)  
579866 L-Asparagine-4-13C monohydrate 99 atom % 13C  
579793 L-Aspartic acid-1,2-13C2 99 atom % 13C  
604895 L-Aspartic acid-2-13C 99 atom % 13C  
489980 L-Aspartic acid-2,3,3-d3 ≥98 atom % D, ≥98% (CP)  
617539 L-Aspartic acid-3-13C 99 atom % 13C  
586161 L-Aspartic acid-3,4-13C2 99 atom % 13C  
673021 L-Aspartic acid-d7 98 atom % D, 98% (CP)  
332135 L-Aspartic acid-15N 98 atom % 15N  
734187 L-Citrulline-5-13C,5,5-d2 S & P tested, 98 atom % D, 99 atom % 13C, 98% (CP) S & P tested
676128 L-Cysteine-1-13C 99 atom % 13C, 98% (CP)  
701424 L-Cysteine-2,3,3-d3 98 atom % D, 97% (CP)  
676136 L-Cystine-1,1′-13C2 99 atom % 13C, 98% (CP)  
592471 N,N-Dimethyl-d6-glycine hydrochloride 99 atom % D  
605123 L-Glutamic acid-2-13C 99 atom % 13C  
631973 DL-Glutamic acid-2,3,3,4,4-d5 98 atom % D  
587672 L-Glutamic acid-4-13C 99 atom % 13C  
605255 D-Glutamic acid-5-13C 99 atom % 13C  
332143 L-Glutamic acid-15N 98 atom % 15N  
605220 L-Glutamine-1,2-13C2 ≥98 atom % 13C  
660809 L-Glutamine-1,2-13C2 S & P tested, 99 atom % 13C S & P tested
605085 L-Glutamine-2-13C 99 atom % 13C  
490032 L-Glutamine-15N2 98 atom % 15N  
616303 L-Glutamine-2,3,3,4,4-d5 98 atom % D, 98% (CP)  
750506 L-Glutamine-4-13C 99 atom % 13C  
279420 Glycine-1-13C 99 atom % 13C  
660728 Glycine-1-13C S & P tested, 99 atom % 13C S & P tested
660736 Glycine-15N S & P tested, 98 atom % 15N S & P tested
299294 Glycine-15N 98 atom % 15N  
283827 Glycine-13C2 99 atom % 13C  
279439 Glycine-2-13C 99 atom % 13C  
336459 Glycine-2,2-d2 98 atom % D  
662135 Nτ-Methyl-d3-L-histidine 98 atom % D, 99% (CP)  
604771 L-Isoleucine-1-13C 99 atom % 13C, 98% (CP)  
490059 L-Leucine-1-13C 99 atom % 13C  
661538 L-Leucine-1-13C S & P tested, 99 atom % 13C S & P tested
490067 L-Leucine-1-13C,15N 98 atom % 15N, 99 atom % 13C  
661546 L-Leucine-1-13C,15N S & P tested, 99 atom % 13C, 98 atom % 15N S & P tested
604909 L-Leucine-1,2-13C2 99 atom % 13C, S & P tested S & P tested
704504 L-Leucine-2-d 97 atom % D, 98% (CP)  
486817 L-Leucine-2-13C 99 atom % 13C  
492949 L-Leucine-2,3,3,4,5,5,5,5′,5′,5′-d10 98 atom % D  
604828 L-Leucine-3-13C 99 atom % 13C, 99% (CP)  
615978 L-Leucine-4-d1 99 atom % D  
486825 L-Leucine-5,5,5-d3 99 atom % D  
661554 L-Leucine-5,5,5-d3 S & P tested, 99 atom % D S & P tested
762369 L-Leucine-13C6 S & P tested, ≥99 atom % 13C, ≥97% (CP) S & P tested
340960 L-Leucine-15N 98 atom % 15N  
660825 L-Leucine-15N 98 atom % 15N, S & P tested S & P tested
615986 L-Leucine-(isopropyl-d7) 98 atom % D  
604704 L-Lysine-1-13C hydrochloride 99 atom % 13C, 98% (CP)  
660833 L-Lysine-1-13C hydrochloride S & P tested, 99 atom % 13C S & P tested
609021 L-Lysine-15N2 hydrochloride 98 atom % 15N, 98% (CP)  
592900 L-Lysine-2−15N dihydrochloride 98 atom % 15N, 98% (CP)  
608963 L-Lysine-2-15N hydrochloride 98 atom % 15N  
660868 L-Lysine-2-15N hydrochloride S & P tested, 98 atom % 15N S & P tested
608971 L-Lysine-ε-15N hydrochloride 98 atom % 15N, 99% (CP)  
490083 L-Methionine-1-13C 99 atom % 13C  
752053 L-Methionine-1,2,3,4-13C4 99 atom % 13C, 98% (CP)  
589802 L-Methionine-2-d1 98 atom % D  
609242 L-Methionine-15N 98 atom % 15N, 98% (CP)  
608149 L-Methionine-(carboxy-13C,methyl-d3) 99 atom % 13C, 99 atom % D  
660876 L-Methionine-(carboxy-13C,methyl-d3) S & P tested, 98 atom % D, 99 atom % 13C S & P tested
589780 D-Methionine-(methyl-13C) 99 atom % 13C  
299146 L-Methionine-(methyl-13C) 99 atom % 13C  
300616 L-Methionine-(methyl-d3) 98 atom % D  
661562 L-Methionine-(methyl-d3) S & P tested, 98 atom % D S & P tested
605042 L-Phenyl-1-13C-alanine 99 atom % 13C  
490091 L-Phenylalanine-1-13C 99 atom % 13C  
661600 L-Phenylalanine-1-13C S & P tested, 99 atom % 13C, 99% (CP) S & P tested
490113 L-Phenylalanine-2-13C 99 atom % 13C  
589438 L-Phenylalanine-2-d1 98 atom % D  
490121 L-Phenylalanine-3-13C 99 atom % 13C  
615889 L-Phenylalanine-3,3-d2 98 atom % D  
615870 L-Phenyl-d5-alanine 98 atom % D  
661619 L-Phenyl-d5-alanine S & P tested, 98 atom % D S & P tested
490148 L-Phenyl-d5-alanine-2,3,3-d3 98 atom % D, 99% (CP)  
604879 L-Phenyl-13C6-alanine 99 atom % 13C  
660884 L-Phenyl-13C6-alanine S & P tested, 99 atom % 13C S & P tested
608017 L-Phenylalanine-13C9,15N 98 atom % 13C, 98 atom % 15N, 95% (CP)  
704466 L-Phenylalanine-13C9,15N S & P tested, 98 atom % 15N, 98 atom % 13C, 95% (CP) S & P tested
795844 L-Phenylalanine-13C9 98 atom % 13C, 95% (CP)  
490105 L-Phenylalanine-15N 98 atom % 15N  
660892 L-Phenylalanine-15N S & P tested, 98 atom % 15N S & P tested
589497 L-Proline-1-13C 99 atom % 13C  
661627 L-Proline-1-13C S & P tested, 99 atom % 13C S & P tested
791261 L-Proline-2,5,5-d3 98 atom % D, 97%  
608998 L-Proline-15N ≥95 atom % 15N, 98% (CP)  
634093 L-Selenomethionine-(methyl-13C) 99 atom % 13C  
490156 L-Serine-1-13C 99 atom % 13C  
604712 L-Serine-2-13C 99 atom % 13C  
605174 L-Serine-2,3-13C2 99 atom % 13C  
604720 L-Serine-3-13C 99 atom % 13C  
609005 L-Serine-15N 98 atom % 15N, 98% (CP)  
605034 L-Threonine-1-13C 99 atom % 13C, 97% (CP)  
720518 L-Threonine-1-13C S & P tested, 99 atom % 13C, 97% (CP) S & P tested
668060 L-Threonine-1,2-13C2 99 atom % 13C, 97% (CP)  
677604 L-Threonine-13C4 98 atom % 13C, 95% (CP)  
607770 L-Threonine-13C4,15N 98 atom % 13C, 98 atom % 15N  
672955 L-Threonine-13C4,15N S & P tested, 98 atom % 13C, 98 atom % 15N, 95% (CP) S & P tested
604836 L-Tryptophan-1-13C 99 atom % 13C, 98% (CP)  
615862 L-Tryptophan-(indole-d5) 97 atom % D  
604844 L-Tryptophan-(indole ring-2-13C) 98 atom % 13C, 96% (CP)  
489824 L-Tyrosine-1-13C ≥99 atom % 13C, ≥98% (CP)  
605107 L-Tyrosine-2-13C 97 atom % 13C, 99% (CP)  
485829 L-Tyrosine-2,6-d2 98 atom % D  
489859 L-Tyrosine-3-13C 99 atom % 13C, 99% (CP)  
489840 L-Tyrosine-3,3-d2 98 atom % D, 99% (CP)  
607991 L-Tyrosine-13C9,15N 98 atom % 15N, 98 atom % 13C, 95% (CP)  
740977 L-Tyrosine-13C9,15N S & P tested, 98 atom % 15N, 98 atom % 13C, 98% (CP) S & P tested
332151 L-Tyrosine-15N 98 atom % 15N  
609919 L-Tyrosine-(4-hydroxy-18O) 95 atom % 18O  
489816 L-Tyrosine-(phenyl-3,5-d2) 98 atom % D, 99% (CP)  
489808 L-Tyrosine-(phenyl-d4) 98 atom % D  
661503 L-Tyrosine-(phenyl-d4) S & P tested, 98 atom % D S & P tested
605093 L-Tyrosine-(phenyl-4-13C) 99 atom % 13C  
489794 L-Tyrosine-(phenyl-13C6) 99 atom % 13C, 99% (CP)  
660752 L-Tyrosine-(phenyl-13C6) S & P tested, 99 atom % 13C S & P tested
746290 L-Tyrosine-(phenyl-3,5-d2) 98 atom % D, 99% (CP), S & P tested S & P tested
490164 L-Valine-1-13C 99 atom % 13C  
660906 L-Valine-1-13C S & P tested, 99 atom % 13C S & P tested
604917 L-Valine-2-13C 99 atom % 13C, 99% (CP)  
490172 L-Valine-15N 98 atom % 15N