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Labeled Amino Acids

for Metabolic Research

Many amino acids are essential during some point of life. They are functionally diverse, serving as building blocks in protein, peptide and amino acid syntheses and playing crucial roles in pathways such as energy metabolism. The use of stable isotope labeled amino acids within metabolic research allows the analytical tracking of the amino acid or of a correspondingly labeled down field metabolite. The pathway and metabolite under study depend on both the amino acid and the labeling pattern. This specificity allows the researcher to take advantage of differences in overlapping pathways, which is not possible with natural abundance amino acids. Due to the versatility, researchers have used stable isotope labeled amino acids to study and verify nutritional requirements,1 to measure muscle protein synthesis,2 and for the confirmation of metabolic pathways such as amino acid synthesis.3

The stable isotope labeled amino acid selection offered by Isotec Stable Isotopes includes all the standard amino acids in varying labeling patterns as well as several other metabolically interesting amino acids. For the majority of the amino acids offered, S&P (sterility and pyrogen) tested material is routinely available and for all others, S&P testing can be requested.

1. a) Chapman, K.P.; Courtney-Martin, G.; Moore, A.M.; Langer, J.C.; Tomlinson, C.; Ball, R.O.; Pencharz, P.B.; Am. J. Clin. Nutr. 2010, 91, 958. b) Courtney-Martin, G.; Moore, A.M.; Ball, R.O.; Pencharz, P.B.; Pediatric Res. 2010, 67, 320.
2. a) Symons, T.B.; Sheffield-Moore, M.; Wolfe, R.R.; Paddon-Jones, D.; J. Am. Diet. Assoc. 2009, 109, 1582. b) Doessing, S.; Heinemeier, K.M.; Holm, L.; Mackey, A.L.; Schjerling, P.; Rennie, M.; Smith, K.; Reitelseder, S.; Kappelgaard, A.-M.; Rasmussen, M.;H.; Flyvbjerg, A.; Kjar, M.; J. Physiol. 2010, 588, 341. 3. Tomlinson, C.; Rafii, M.; Sgro, M.; Ball, R. O.; Pencharz, P.; Pediatric Res. 2011, 69, 46.

Product #

Description

Grade

Add to Cart

489867 L-Alanine-1-13C 99 atom % 13C  
486779 L-Alanine-2-13C 99 atom % 13C  
485845 L-Alanine-2,3,3,3-d4 98 atom % D  
488917 DL-Alanine-2,3,3,3-d4 98 atom % D  
489875 L-Alanine-13C3 98 atom % 13C, 95% (CP)  
489948 L-Alanine-3-13C 99 atom % 13C  
489921 L-Alanine-3,3,3-d3 99 atom % D  
332127 L-Alanine-15N 98 atom % 15N  
600113 L-Arginine-15N4 hydrochloride 98 atom % 15N, 97% (CP)  
609080 L-Arginine-(guanidineimino-15N2) hydrochloride 98 atom % 15N, 98% (CP)  
641960 L-Asparagine-15N2 98 atom % 15N, 98% (CP)  
485918 L-Asparagine-15N2 monohydrate 98 atom % 15N, 98% (CP)  
579866 L-Asparagine-4-13C monohydrate 99 atom % 13C  
332135 L-Aspartic acid-15N 98 atom % 15N  
332143 L-Glutamic acid-15N 98 atom % 15N  
490032 L-Glutamine-15N2 98 atom % 15N  
279420 Glycine-1-13C 99 atom % 13C  
299294 Glycine-15N 98 atom % 15N  
283827 Glycine-13C2 99 atom % 13C  
279439 Glycine-2-13C 99 atom % 13C  
336459 Glycine-2,2-d2 98 atom % D  
490059 L-Leucine-1-13C 99 atom % 13C  
492949 L-Leucine-2,3,3,4,5,5,5,5′,5′,5′-d10 98 atom % D  
486825 L-Leucine-5,5,5-d3 99 atom % D  
340960 L-Leucine-15N 98 atom % 15N  
609021 L-Lysine-15N2 hydrochloride 98 atom % 15N, 98% (CP)  
490083 L-Methionine-1-13C 99 atom % 13C  
609242 L-Methionine-15N 98 atom % 15N, 98% (CP)  
299146 L-Methionine-(methyl-13C) 99 atom % 13C  
300616 L-Methionine-(methyl-d3) 98 atom % D  
490091 L-Phenylalanine-1-13C 99 atom % 13C  
490113 L-Phenylalanine-2-13C 99 atom % 13C  
490121 L-Phenylalanine-3-13C 99 atom % 13C  
615889 L-Phenylalanine-3,3-d2 98 atom % D  
615870 L-Phenyl-d5-alanine 98 atom % D  
490148 L-Phenyl-d5-alanine-2,3,3-d3 98 atom % D, 99% (CP)  
604879 L-Phenyl-13C6-alanine 99 atom % 13C  
608017 L-Phenylalanine-13C9,15N 98 atom % 13C, 98 atom % 15N, 95% (CP)  
490105 L-Phenylalanine-15N 98 atom % 15N  
589497 L-Proline-1-13C 99 atom % 13C  
608998 L-Proline-15N ≥95 atom % 15N, 98% (CP)  
490156 L-Serine-1-13C 99 atom % 13C  
604720 L-Serine-3-13C 99 atom % 13C  
609005 L-Serine-15N 98 atom % 15N, 98% (CP)  
607770 L-Threonine-13C4,15N 98 atom % 13C, 98 atom % 15N  
615862 L-Tryptophan-(indole-d5) 97 atom % D  
489824 L-Tyrosine-1-13C ≥99 atom % 13C, ≥98% (CP)  
607991 L-Tyrosine-13C9,15N 98 atom % 15N, 98 atom % 13C, 95% (CP)  
332151 L-Tyrosine-15N 98 atom % 15N  
489816 L-Tyrosine-(phenyl-3,5-d2) 98 atom % D, 99% (CP)  
489808 L-Tyrosine-(phenyl-d4) 98 atom % D  
489794 L-Tyrosine-(phenyl-13C6) 99 atom % 13C, 99% (CP)  
490164 L-Valine-1-13C 99 atom % 13C  
490172 L-Valine-15N 98 atom % 15N