Labeled Carbohydrates

for Metabolic Research

Carbohydrates, and glucose specifically, play a key role in the study of metabolic research. Glucose is involved, either directly or via a downstream metabolite, in numerous biochemical pathways. Stable isotope labeled glucose has therefore been a popular and reliable substrate used in an array of applications. This research includes the study of diseases such as diabetes1 and cancer,2 the effect of energy expenditure on glucose production3 and the metabolic effects of pharmaceuticals such as antipsychotic drugs.4 Due to the variety of metabolic cycles fed by glucose and the numerous metabolites biosynthesized from glucose, many labeled glucose products are available.

While glucose is the most heavily researched carbohydrate, metabolic research using carbohydrates is not limited to glucose. Various studies have been undertaken using labeled carbohydrates such as fructose and ribose. Recent studies have included research into the effects of carbohydrates on energy metabolism,5 the study of carbohydrate metabolism with regards to an increased in high fructose corn syrup consumption,6 and study into the biosynthesis of certain flavor components by yeast.7

1. Beysen, C.; Murphy, E.J.; Nagaraja, H.; Decaris, M.; Riif, T.; Fong, A.; Hellerstine, M.K.; Boyle, P.; J. Lipid Res. 2008, 2657.
2. Lane, A.N.; Fan, T.;W.-M.; higashi, R.M.; Tan, J.; Bousamra, M.; Miller, D.M.; Exp.Mol.Pathol. 2009, 86, 165.
3. Smith, T.J.; Schwartz, J.-M.; Montain, S.J.; Rood, J.; Pikosky, M.A.; Castaneda-Sceppa, C.; Glickman, E.; Young, A.J.; Nutr. Metab. 2011, 8:26..
4. Vidarsdottir, S.; de Leeuw van Weenen, J.E.; Frölich, M.; Roelfsema, F.; Romijn, J.A.; Pijl, H.; J. Clin. Endocrinol. Metab. 2010 95, 118.
5. Bruce, S.J.; Breton, I.; Decombaz, J.; Boesch, C.; Scheurer, E.; Montoliu, I.; Rezzi, S.; Kochhar, S.; Guy, P.A.; J. Chrom. B 2010, 878, 3015.
6. Wahjudi, P.N.; Patterson,M.E.; Lim,S.; Yee, J.K.; Mao, C.S.; Lee, W.-N. P.; Clin.Biochem. 2010, 43, 198.
7. Ohata, M.; Kohama, K.; Morimitsu, Y.; Kubota, K.; Sugawara, E.; Biosci. Biotechnol. Biochem. 2007, 71, 407.

Technical Article
An Approach to Quantifying the Conversion of Carbohydrate to Fat in Humans (J.-M.Schwarz, Ph.D. and N.Bergeron, Ph.D.)

Product #

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426415 D-Arabinose-1-13C 99 atom % 13C  
696498 Cellulose-13C 97 atom % 13C, from maize  
415553 D-Fructose-1-13C 99 atom % 13C  
729051 D-Fructose-1,1,3,4,5,6,6-d7 97 atom % D  
587613 D-Fructose-1,6-13C2 98 atom % 13C  
492140 D-Fructose-2-13C 99 atom % 13C  
587621 D-Fructose-13C6 99 atom % 13C, 99% (CP)  
605395 D-Fructose-6-13C 99 atom % 13C  
488720 D-Fructose-6,6-d2 ≥98 atom % D, ≥99% (CP)  
723908 D-Fructose-d12 98 atom % D  
495077 D-Galactose-1-d 98 atom % D  
661392 D-Galactose-1-d S & P tested, 98 atom % D S & P tested
661406 D-Galactose-1-13C S & P tested, 99 atom % 13C S & P tested
454621 D-Galactose-2-13C 99 atom % 13C  
605379 D-Galactose-13C6 98 atom % 13C  
297046 D-Glucose-1-13C 99 atom % 13C  
660655 D-Glucose-1-13C S & P tested, 99 atom % 13C S & P tested
310816 D-Glucose-1-d1 98 atom % D  
453188 D-Glucose-1,2-13C2 99 atom % 13C  
661422 D-Glucose-1,2-13C2 S & P tested, 99 atom % 13C S & P tested
720127 D-Glucose-1,2,3-13C3 99 atom % 13C, 99% (CP)  
706663 D-Glucose-1,2,3,4,5,6,6-d7 S&P Tested, 97 atom % D  
453196 D-Glucose-1,6-13C2 ≥99 atom % 13C, ≥99% (CP)  
661449 D-Glucose-1,6-13C2 S & P tested, ≥99 atom % 13C, ≥99% (CP) S & P tested
661457 D-Glucose-2-13C S & P tested, 99 atom % 13C S & P tested
310824 D-Glucose-2-d 98 atom % D, 99% (CP)  
605409 D-Glucose-3-13C 99 atom % 13C, 99% (CP)  
615498 D-Glucose-3-d1 97 atom % D  
668648 D-Glucose-4-13C 99 atom % 13C  
605468 D-Glucose-4,5-13C2 99 atom % 13C  
731501 D-Glucose-4,5,6-13C3 99 atom % 13C  
755893 D-Glucose-5,6-13C2 99 atom % 13C, 99% (CP)  
389374 D-Glucose-13C6 ≥99 atom % 13C, ≥99% (CP)  
660663 D-Glucose-13C6 S & P tested, 99 atom % 13C S & P tested
310808 D-Glucose-6-13C 99 atom % 13C  
661430 D-Glucose-6-13C S & P tested, 99 atom % 13C S & P tested
282650 D-Glucose-6,6-d2 ≥98 atom % D, ≥99% (CP)  
661414 D-Glucose-6,6-d2 S & P tested, ≥98 atom % D, ≥99% (CP) S & P tested
734403 D-Glucose-6-13C,6,6-d2 99 atom % 13C, 98 atom % D, 98% (CP)  
616184 myo-Inositol-C-d6 98 atom % D, 98% (CP)  
608181 D-Mannitol-1-13C,1,1-d2 ≥98 atom % D, ≥99 atom % 13C, ≥99% (CP)  
900499 D-Mannitol-1,6-13C2 ≥99 atom % 13C, ≥97% (CP)  
591424 D-Mannitol-2-13C 99 atom % 13C  
605492 D-Mannitol-13C6 99 atom % 13C, 99% (CP)  
415537 D-Mannose-1-13C 99 atom % 13C  
605344 D-Mannose-2-13C 99 atom % 13C  
749419 D-Mannose-3-13C 99 atom % 13C, 97% (CP)  
733733 D-Mannose-4-13C 99 atom % 13C, 97% (CP)  
592994 D-Mannose-13C6 98 atom % 13C  
605387 D-Mannose-6-13C 99 atom % 13C  
605352 D-Ribose-1-13C 99 atom % 13C  
605476 D-Ribose-1,2-13C2 99 atom % 13C  
310840 D-Ribose-2-13C 99 atom % 13C  
605484 D-Ribose-2,3,4,5-13C4 99 atom % 13C, 99% (CP)  
798258 D-Ribose-13C5 99 atom % 13C, 99%  
489182 D-Sorbitol-1-13C 99 atom % 13C  
616206 D-Sorbitol-1,1,6,6-d4 98 atom % D  
605514 D-Sorbitol-13C6 99 atom % 13C, 99% (CP)  
605336 Starch-13C from algae 99 atom % 13C, Crude  
605417 Sucrose-13C12 99 atom % 13C, 99% (CP)  
738794 Sucrose-(fructose-13C6) 99 atom % 13C  
705136 Sucrose-(glucose-1-13C) 99 atom % 13C  
738786 Sucrose-(glucose-13C6) 99 atom % 13C  
700452 α,α-Trehalose-1,1′-d2 98 atom % D, 97% (CP)  
738921 α,α−Trehalose-13C12 99 atom % 13C, 99% (CP)  
331104 D-Xylose-1-13C 99 atom % 13C  
666378 D-Xylose-13C5 98 atom % 13C, 99% (CP)