技术聚焦

MeOBIPHEP

介绍

当前最先进的阻转异构体MeOBIPHEP配体,又称为MeO-BIPHEP,最初是由Roche开发的,由于其采用了模块化配体设计,因此在许多合成应用中具有非常广泛的性能特征。从大多数角度来看,MeOBIPHEP配体的催化特征与BINAP及其它多种类似二膦阻转异构体的催化特征都非常类似1-4。PR2基团的性质会强烈影响金属配合物的催化性能,Sigma-Aldrich可以为您提供研究用所需量、具有不同空间体积的配体代表样品。

参考文献:

  1. Mordant, C. et al. Synthesis 2003, 2405.
  2. Wang, W.-B. et al. J. Am. Chem. Soc. 2003, 125, 10536.

返回页首

 

C–C 偶联反应

Krische研究小组报道了乙炔通过对映选择性Rh催化还原偶联生成醛以及α-酮酯,使用29510得到高收率和对映选择性的相应二烯醇(公式1)。 Wiedenhoefer小组报道了2-(4-戊烯基)吲哚的分子内不对称氢化反应,该反应收率在中等到良好之间,采用二氯铂络合物和(S)-3,5-t-Bu-4-MeO-MeOBIPHEP 29511的1:1混合物进行催化(>90% ee)(公式2)。Pregosin及其合作者报道了在使用(R)-3,5-t-Bu-MeOBIPHEP 29524 时,芳基三氟甲磺酸酯生成2-取代二氢呋喃的Pd催化Heck反应的对映选择性得到显著提高(公式3)。

 

MeOBIPHEP Scheme 4 Image

方案 4

 

参考文献

  1. Tschoerner, M. et al. Organometallics 1999, 18, 670.

返回首页

 

货号 产品名称 结构 加入购物车
29510 (R)-(+)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine) 29510 Structure Image
29511 (S)-(-)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine) 29511 Structure Image
29512 (R)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphine] 29512 Structure Image
29513 (S)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphine] 29513 Structure Image
29514 (R)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis(di-2-furylphosphine) 29514 Structure Image
29515 (S)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis(di-2-furylphosphine) 29515 Structure Image
29516 (R)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(3,5-dimethylphenyl)phosphine] 29516 Structure Image
29517 (S)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(3,5-dimethylphenyl)phosphine] 29517 Structure Image
29518 (R)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis(diisopropylphosphine) 29518 Structure Image
29519 (S)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis(diisopropylphosphine) 29519 Structure Image
29520 (R)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(4-methylphenyl)phosphine] 29520 Structure Image
29521 (S)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(4-methylphenyl)phosphine] 29521 Structure Image
29524 (R)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(3,5-di-tert-butylphenyl)phosphine] 29524 Structure Image
29525 (S)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(3,5-di-tert-butylphenyl)phosphine] 29525 Structure Image
29526 (R)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine] 29526 Structure Image
29527 (S)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine] 29527 Structure Image
29528 (R)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis{bis[3,5-diisopropyl-4-(dimethylamino)phenyl]phosphine} 29528 Structure Image
29529 (S)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis{bis[3,5-diisopropyl-4-(dimethylamino)phenyl]phosphine} 29529 Structure Image

返回首页