化学合成

有机三氟硼酸盐

有力的硼酸替代品

在一系列碳-碳键催化合成反应中,Suzuki-Miyaura步骤是一种公认非常有吸引力的方法。有机硼烷亲核试剂(硼酸、硼酸酯和有机三氟硼酸钾)可在温和条件、存在敏感官能团(例如OH、CO2H、CN、CHO等)的情况下非常轻松地进行交叉偶联。但硼酸和硼酸酯都存在一定的限制。硼酸难以纯化,会三聚成相应的环硼氧烷,具有不确定的化学计量性。硼酸酯缺乏原子经济性,并且由于频哪醇或儿茶酚而导致成本进一步增加,变得非常昂贵(图1)。

作为替代品的有机三氟硼酸钾具有明确的化学计量,具有低分子量,对空气和水分不敏感,易处理,呈易于储存的结晶固体形式(图2)1

 

在Suzuki-Miyaura交叉偶联反应中采用烷基-、烯基-、芳基-和杂芳基三氟硼酸钾,可以得到多用途合成中间体,包括:1,3-二烯,苯乙烯,大位阻联芳基化合物和高度官能化的杂环化合物(图3)2

除了Suzuki-Miyaura偶联之外,有机三氟硼酸钾还可以参与各种其他有用的反应,包括1,2-和1,4-加成,C-O和C-N键形成,卤化和烯丙基化(图4)3




   产品信息


货号 产品名称 结构式 加入购物车
637890 Potassium methyltrifluoroborate
659274 Potassium allyltrifluoroborate, 95%
660094 Potassium butyltrifluoroborate, 95%
563056 Potassium benzyltrifluoroborate, 95%
563099 Potassium phenethyltrifluoroborate, 95%
655228 Potassium vinyltrifluoroborate, 95%
637882 Potassium trans-1-decenyltrifluoroborate, 95%
576158 Potassium trans-styryltrifluoroborate
563951 Potassium phenyltrifluoroborate, 95%
571547 Potassium 4-bromophenyltrifluoroborate
571555 Potassium p-tolyltrifluoroborate
571563 Potassium 3,5-bis(trifluoromethyl)-phenyltrifluoroborate
571598 Potassium 3-nitrophenyltrifluoroborate
576093 Potassium 4-formylphenyltrifluoroborate
576107 Potassium 2-bromophenyltrifluoroborate, 96%
576115 Potassium 3-methoxyphenyltrifluoroborate, 96%
576123 Potassium o-tolyltrifluoroborate
576131 Potassium 4-(trifluoromethyl)-phenyltrifluoroborate, 96%
579068 Potassium 4-methoxyphenyltrifluoroborate, 95%
592846 Potassium 4-fluorophenyltrifluoroborate, 95%
592943 Potassium 2,6-dimethylphenyltrifluoroborate, 95%
597929 Potassium 2,6-difluorophenyltrifluoroborate
654728 Potassium 4-tert-butylphenyltrifluoroborate, 95%
654930 Potassium 2-methoxyphenyltrifluoroborate, 95%
656992 Potassium 2,4-difluorophenyltrifluoroborate, 95%
657018 Potassium 2-naphthalenetrifluoroborate
657050 Potassium 4-acetylphenyltrifluoroborate, 97%
657069 Potassium 4-carboxyphenyltrifluoroborate, 97%
657077 Potassium 4-chlorophenyltrifluoroborate, 95%
657085 Potassium 2,6-dimethoxyphenyltrifluoroborate, 95%
657093 Potassium 3-formylphenyltrifluoroborate, 95%
657115 Potassium 4-(methylthio)-phenyltrifluoroborate, 95%
659746 Potassium 3-hydroxyphenyltrifluoroborate, 96%
659762 Potassium 4-(hydroxymethyl)-phenyltrifluoroborate
659770 Potassium 3-fluorophenyltrifluoroborate, 96%
659789 Potassium 3-carboxyphenyltrifluoroborate, 97%
659754 Potassium 3,4-(methylenedioxy)-phenyltrifluoroborate
571571 Potassium 3-thiophenetrifluoroborate
654949 Potassium 5-methyl-2-thiophenetrifluoroborate, 95%

CheminarTM 1.2有机三氟硼酸钾:高性能的硼酸/酯替代品

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