Andrei Yudin研究小组 - 教授产品门户

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Andrei Yudin教授 Andrei Yudin教授

Yudin实验室以开发两性分子及其在合成中的应用而闻名。对应试剂具有不会过早发生相互反应的亲核和亲电官能团。多年来,Yudin和他的学生开发了一系列基于氮丙啶醛、α-硼烷醛和酰基硼酸酯的工艺。这些分子已被应用在药物相关杂环化合物、大环化合物和肽模拟物的合成中。温和的反应条件,对保护基团的最小依赖以及获得无法通过其他方式获得的支架的可能性是该技术的主要区别特征。

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Yudin实验室最近发表的文章

Ryan Hili, Andrei K Yudin
Journal of the American Chemical Society 2006-11-22
We report a new class of bench-stable compounds that contain seemingly incompatible functional groups: an aldehyde and an unprotected secondary amine. The thermodynamic driving force to undergo condensation between these two functionalities is offset by a high barrier imposed on this process by the aziridine ring strain. The res...Read More
Zhi He, Andrei K Yudin
Journal of the American Chemical Society 2011-09-07
A new class of stable molecules, α-boryl aldehydes, has been prepared from oxiranyl N-methyliminodiacetyl boronates by a 1,2-boryl migration with concomitant epoxide scission. A range of boryl imines, alkenes, alcohols, acids, enol ethers, enamides, and other functionalized boronic acid derivatives that are difficult or impossib...Read More
Zhi He, Piera Trinchera, Shinya Adachi, Jeffrey D St Denis, Andrei K Yudin
Angewandte Chemie. International edition in English 2012-10-29
Excellent tolerance: Stable acylboronates equipped with N-methyliminodiacetyl (MIDA) boryl groups ([B]) were prepared by using a sequence of oxidative manipulations at the boron-bound carbon center (green in scheme). Chemoselective transformations of these acylated organoboron building blocks yielded a range of multifunctionaliz...Read More