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       Jonathan A. Ellman教授

Ellman研究小组参与了各种C-H功能化方法的开发,其中一种富电子膦配体在杂环合成中各种Rh(I)催化的CC键形成的反应中的可用性已得到了证明,如最近的《科学》论文“Proton Donor Acidity Controls Selectivity in Nonaromatic Nitrogen Heterocycle Synthesis”中的实例所述。另一种有用的配体为在“Rh(I)-Catalyzed Arylation of Heterocycles via C-H Bond Activation: Expanded Scope through Mechanistic Insight.”(发表于 J.Am.Chem.Soc.2003,49,4154)中所描述的具有高官能团相容性的氮杂环直接芳基化用配体。

Ellman研究小组还开发了一种手性胺试剂——叔丁基亚磺酰胺,其在学术界和工业界被广泛用于胺的不对称合成。 2010年Chemical Reviews文章“Synthesis and Applications of tert-Butanesulfinamide”中总结了截至2009年为止关于叔丁烷亚磺酰胺方法和应用的综述。

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Ellman实验室最近发表的文章:

Simon Duttwyler, Shuming Chen, Michael K Takase, Kenneth B Wiberg, Robert G Bergman, Jonathan A Ellman
Science 2013-02-08
Piperidines are prevalent in natural products and pharmaceutical agents and are important synthetic targets for drug discovery and development. We report on a methodology that provides highly substituted piperidine derivatives with regiochemistry selectively tunable by varying the strength of acid used in the reaction. Readily a...Read More
MaryAnn T Robak, Melissa A Herbage, Jonathan A Ellman
Chemical Reviews 2010-06-09
Jared C Lewis, Ashley M Berman, Robert G Bergman, Jonathan A Ellman
Journal of the American Chemical Society 2008-02-27
A practical, functional group tolerant method for the Rh-catalyzed direct arylation of a variety of pharmaceutically important azoles with aryl bromides is described. Many of the successful azole and aryl bromide coupling partners are not compatible with methods for the direct arylation of heterocycles using Pd(0) or Cu(I) catal...Read More