Molander研究小组 - 教授产品门户

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       Gary Molander教授

Molander研究小组的研究中心主题是开发新合成方法,及其在合成有机分子中的应用。该小组目前的重点是扩大和改进有机硼化合物的交叉偶联反应。通过使用稳定的、在空气和水中稳定的有机三氟硼酸钾(R-BF3K),在相对温和的条件下使用无毒组分进行偶联。

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John C Tellis, David N Primer, Gary A Molander
Science 2014-07-25
The routine application of C(sp3)-hybridized nucleophiles in cross-coupling reactions remains an unsolved challenge in organic chemistry. The sluggish transmetalation rates observed for the preferred organoboron reagents in such transformations are a consequence of the two-electron mechanism underlying the standard catalytic approach...Read More
Gary A Molander, Livia N Cavalcanti, Carolina García-García
Journal of Organic Chemistry 2013-07-05
Arylboronic acids are gaining increased importance as reagents and target structures in a variety of useful applications. Recently, the palladium-catalyzed synthesis of arylboronic acids employing the atom-economical tetrahydroxydiboron (BBA) reagent has been reported...Read More
Marc Presset, Daniel Oehlrich, Frederik Rombouts, Gary A Molander
Journal of Organic Chemistry 2013-12-20
Copper-mediated trifluoromethylation of unsaturated organotrifluoroborates with the Langlois reagent (NaSO2CF3) and TBHP allows the introduction of trifluoromethyl groups into a variety of organic substructures. The reactions are easy to set up, the conditions are mild and general, and the process provides access to trifluoromethylated alkynes, alkenes, arenes, and heteroarenes in fair to good yields...Read More
Gary A Molander, Sarah L J Trice, Steven M Kennedy, Spencer D Dreher, Matthew T Tudge
Journal of the American Chemical Society 2012-07-18
The Suzuki-Miyaura reaction has become one of the more useful tools for synthetic organic chemists. Until recently, there did not exist a direct way to make the most important component in the coupling reaction, namely the boronic acid. Current methods to make boronic acids often employ harsh or wasteful reagents to prepare boro...Read More
Gary A Molander, Sarah L J Trice, Steven M Kennedy
Journal of Organic Chemistry 2012-10-05
The use of bis-boronic acid for the direct synthesis of boronic acids has greatly facilitated the two-step, one-pot borylation/Suzuki cross-coupling reaction between aryl and heteroaryl halides. With use of Buchwald's second-generation XPhos preformed catalyst, high yields of cross-coupled products were obtained for most substra...Read More