Jeffrey W. Bode 研究小组 - 教授产品门户

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        Jeffrey W. Bode教授

Bode研究小组的目标包括开发用于合成复杂分子的新反应和试剂。

Bode研究小组开发了N-均三甲苯基取代的NHCs,其可以作为活性物质催化合成的有机催化剂,包括活性羧酸盐、高烯醇化物和烯醇化物。这些新催化剂和反应使得人们可以在温和的反应条件下,通常是室温且无需添加剂的情况下,由简单的起始材料生成新一代高对映选择性环。

为了进一步设计新试剂以实现复杂分子的组装,Bode研究小组还开发了SnAP试剂,以便将醛类通过方便的一步法转化为N-未保护、饱和N-杂环,包括双环和螺环结构。这些易于操作的试剂为具有挑战性和限制性的饱和N-杂环官能化交叉偶联方法提供了一种简单且强大的替代方法。

Bode研究小组网站

 

Michael U Luescher, Cam-Van T Vo, Jeffrey W Bode
Organic Letters 2014-02-21
Substituted piperazines and morpholines are valuable structural motifs in biologically active compounds, but are not easily prepared by contemporary cross-coupling approaches. In this report, we introduce SnAP reagents for the transformation of aldehydes into N-unprotected piperazines and morpholines. This approach offers simple...Read More
Cam-Van T Vo, Michael U Luescher, Jeffrey W Bode
Nature Chemistry 2014-04-01
Interest in saturated N-heterocycles as scaffolds for the synthesis of bioactive molecules is increasing. Reliable and predictable synthetic methods for the preparation of these compounds, especially medium-sized rings, are limited. We describe the development of SnAP (Sn amino protocol) reagents for the transformation of aldehy...Read More