余金权(Jin-Quan Yu)研究小组 - 教授产品门户

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        余金权(Jin-Quan Yu)教授

祝贺余博士获得2016年度麦克阿瑟奖(又名天才奖)!

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余教授的研究围绕着基于C-H活化来催化生成碳-碳和碳-杂原子键的反应。主要通过选择靶目标转化来实现:1)使用简单和丰富的原材料,如脂肪酸、胺和醇;2)断开,从而大大缩短了药物分子或主要类别的生物活性化合物的合成过程。最后,余教授的研究小组还希望开发出在反应性和选择性上能和酶转化相媲美的催化反应。

为了实现这一目标,他们的研究活动主要针对以下几个方面:C-H活化、可持续催化、不对称催化和合成应用。最近发表的文章强调了导向基团的优化空间位阻和电子效应,其可以在高产率下实现邻位官能化和间C-H键。通过开发多种配体催化体系,余金权教授在对映选择性合成领域保持着领先地位。

余的研究小组网站

Ling Chu, Kai-Jiong Xiao, Jin-Quan Yu
Science 2014-10-24
Asymmetric carbon-hydrogen (C-H) activation reactions often rely on desymmetrization of prochiral C-H bonds on the same achiral molecule, using a chiral catalyst. Here, we report a kinetic resolution via palladium-catalyzed enantioselective C-H iodination in which one of the enantiomers of a racemic benzylic amine substrates und...Read More
Peng-Xiang Shen, Xiao-Chen Wang, Peng Wang, Ru-Yi Zhu, Jin-Quan Yu
Journal of the American Chemical Society 2015-09-16
2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp(2))-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.Read More
Yongwei Wu, Yan-Qiao Chen, Tao Liu, MartinD Eastgate, Jin-Quan Yu
Journal of the American Chemical Society 2016-10-01
Pd(II)-catalyzed Gamma-C(sp(3))-H arylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing gr...Read More