Selection Guide

We carry the popular and high-quality Hamilton, SGE and VICI® Precision Sampling analytical gas and liquid syringes and accessories. The selection of brands gives you choices based on the product offering, application relevance, instrument compatibility, and personal preference. We continually work with our customers, suppliers, and instrument manufacturers to make sure our syringe line stays up-to-date. As with all of our products, they are backed by Sigma-Aldrich’s commitment to innovation, quality, and service.

The right choice of syringe is vital to ensure proper fit and operation within the instrument, accurate and precise injections, and long functional lifetime.

Structurally, syringes must ensure a tight and secure fit in the injection port and withstand repeated injection cycles without bending or breaking. Compositionally, they must be able to withstand chemical and mechanical forces within a defined range. Chemically, they must be inert and not introduce extraneous, interfering compounds into the sample. Syringes also must deliver accurate and precise volumes with no dead volume or carryover between injections.

Syringe Selection
Termination Choices
Needle Point Styles
Needle Gauges

syringe parameters - click to view larger image

Syringe Selection back to top

Liquid Sample Gas/Liquid Sample
Hamilton SGE Hamilton SGE
Microliter MicroVolume Gastight Gas Tight

Manual Injection
Liquid Sample Gas/Liquid Sample
Hamilton Valco VICI SGE Hamilton Valco VICI SGE
600 series
700 series
800 series
900 series
7000 series
Series C-160
Series C-120
Series CG-130
Series D-140
1000 series
1700 series
1800 series
Series A
Series A-2
Series C
Series D

Termination Choices back to top

The termination is the interface, or connection, between the syringe barrel and the needle. The choice depends on the application. Each manufacturer has its own specification nomenclature.

Fixed (cemented) – Economical, reproducible injections, for autosamplers, one syringe-one method, do not heat above 50 °C

Removable needle – One syringe-many methods, simplicity of fi xed needle, but needle can be replaced if damaged or clogged, do not heat above 115 °C

Knurled hub – Creates a leak-tight seal that can be retightened to compensate for wear

Luer tip – Easy, fast needle replacement, syringe fi lter or pump priming, Luer tip is ground glass suitable for mounting chromatographic or PTFE needles, syringes can be autoclaved (without plunger or needle)

Luer-Lok – Security of a locked needle, syringe fi lter or pump priming, PTFE, male Luer taper with nickel-plated brass locking hub for use with KEL-F® or metal hub needles and universal connectors

Syringe-Valves – Syringe with On-Off valves, head space applications, collect and store volatile samples, examples are SampleLock (Hamilton) or Pressure-Lok (VICI).

Hamilton Termination Nomenclature:
N – Fixed needle, RN – Removable needle, LT – Luer tip, KH – Knurled hub, TLL – PTFE Luer-Lok, WG – Plunger guides which prevent bending the syringe, CH – Chaney adapter, SL – SampleLock

SGE Termination Nomenclature:
F – Fixed needle provides reproducible injects at an economical price, R – Removable needle, LL – Luer-Lok, LT – Luer tip, B – Plunger-in-Needle

Needle Point Styles back to top

Standard needles are most often point style 2 (sharp point) or 3 (blunt point). For HPLC injections and sample pipetting, the blunt-tip style 3 is preferred. The blunt tip has chamfered and polished edges that eliminate damage to the valve’s rotor seal and stator face. This style can also be used for pipetting liquids.

For manual GC injections, a beveled tip, like style 2 is preferred for optimum septum penetration and to prevent septum coring. Also, Hamilton point style AS and SGE cone-tip needles are specially designed for this application. When using an autosampler, consult the instrument manual for the preferred point style.

In syringes with point style 5, conical with side port, liquid samples can be filled and dispensed through the hole in the side. Septum damage is minimized by the solid domed tip.

Point Style 2 point style 2 Sharp, beveled, curved, non-coring needle point recommended for septum penetration.
Available gauges: 33-10.
Point Style 3 point style 3 Blunt needle point for use with HPLC injection valves and for sample pipetting.
Available gauges: 33-10
Point Style 4 point style 4 Standard 12° beveled needle point is recommended for life science applications.
Available gauges: 33-10

Special point styles such as 30°, 45°, or any other angle are available upon request.
Point Style 5 point style 5 Conical needle with side port for penetration of septa, thin-gauged vinyls and plastics
without coring. Available gauges: 26-10
Point Style AS point style as Spherical conical style needle point used on autosampler syringes. The non-coring needle point is recommended for septum penetration.
Available gauges: 26-22

Needle Gauges back to top

Gauge is the thickness of the needle. The gauge required depends on the injector. For example, in HPLC applications, Waters instruments use a 25 gauge needle, while Rheodyne, Valco, Altex and SSI valves use 22 gauge.

23 or 23s Single Gauge (0.64 mm)
  • Merlin Microseal™ septa
  • Packed column injector ports
  • Split/splitless injector ports
26 or 26s Single Gauge (0.47 mm)
  • Packed column injector ports
  • Split/splitless injector ports
Dual-Gauge 23-26 or 23s-26s (0.64 - 0.47 mm) Tapered
  • Durability of a 23-gauge
  • Versatility of a 26-gauge for split/splitless and on-column injection