Chemical Synthesis

Lonza Minibulk Agreement

An exclusive global agreement for scale-up quantities of diketene derivatives and organic fine chemicals between Sigma-Aldrich and Lonza Ltd.

Sigma-Aldrich signed a partnership with Swiss-based chemical and biotechnology company Lonza Ltd. to exclusively distribute selected Lonza products globally. Lonza Ltd. is one of the world’s leading suppliers of diketene derivatives, such as diketene esters (acetoacetates) and -amides, dehydroacetic acids and further diketene downstream products, hydrocyanic acid derivatives, nitriles and other organic fine chemicals. Lonza Ltd. has established a leading position in the market by developing and producing fine chemicals for the world’s life science companies for more than 40 years.
Under the agreement Sigma-Aldrich is responsible for the distribution of scale-up quantities (1kg Sample size, 25kg Minibulk Container up to Lonza Original Drums) of Lonza fine chemicals. Larger quantities are directly supplied from Lonza Ltd. allowing customers seamless availability of these products from developmental to manufacturing scale, eliminating the need to qualify a new source as a project moves along the development pathway.

For each Lonza product a Sigma-Aldrich product number has been created with the note “Lonza quality”.

LONZA Diketene Derivatives
Prod. No. Product Name Structure
691380 Diketene-Acetone Adduct

688789 Acetoacetamide

690848 N,N-Dimethylacetoacetamide solution

690945 N,N-Diethylacetoacetamide

688886 Methyl acetoacetate

688983 Ethyl acetoacetate

689092 Isopropyl acetoacetate

688657 Isobutyl acetoacetate

688770 tert-Butyl acetoacetate

691062 2-Methoxyethyl acetoacetate

689866 Benzyl acetoacetate

690082 Ethyl benzoylacetate =91.0%

689963 Ethyl benzoylacetate =98.0%

690295 Ethyl 4-chloroacetoacetate

689106 Ethyl 4,4,4-trifluoroacetoacetate

689319 Dehydroacetic acid

689521 Dehydroacetic acid sodium salt

689424 Dehydroacetic acid sodium salt monohydrate

689203 Squaric acid


690198 Diethyl squarate


688894 Methyl 3-aminocrotonate

689211 1,4-Butanediol bis(3-aminocrotonate)

691178 Thioglycol bis(3-aminocrotonate)

LONZA Hydrocyanic Acid Derivatives and Nitriles
Prod. No. Product Name Structure
691399 Chlorosulfonyl isocyanate

690740 Cyanuric chloride

690953 1,1,3,3-Tetramethylguanidine

690309 Sodium dicyanamide

690414 Malononitrile

691186 Allyl cyanoacetate

691283 Butyl cyanoacetate

691070 2-Methoxyethyl cyanoacetate

690538 3-Aminocrotononitrile

688991 2-Methylbutyronitrile

LONZA Other Organic Fine Chemicals
Prod. No. Product Name Structure
691275 Acetic anhydride

690856 Dimethyl 1,3-acetonedicarboxylate

689750 3-Methyl-5-pyrazolone