Greener Alternatives Learning Center


Staying at the forefront of green chemistry is challenging.  We've started to aggregate the best and brightest papers, thought leaders and resources to connect you with best practices in green chemistry to help reduce the environmental footprint of your research. If you have suggestions about additional resources you'd like to see simple email us at


 Green News

Cyrene as a Bio-Based Solvent for the Suzuki–Miyaura Cross-Coupling
Kirsty L. Wilson, Jane Murray, Craig Jamieson, and Allan J. B. Watson
Synlett, Vol. 29, Issue, 05, pp.650-654, 2018

Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
Kirsty L Wilson, Alan R Kennedy, Jane Murray, Ben Greatrex, Craig Jamieson, and Allan J B Watson
Beilstein Journal of Organic Chemistry, Vol. 12, pp. 2005–2011, 2016

A New Approach to Sustainability: A Moore's Law for Chemistry
Prof. Martyn Poliakoff , Prof. Peter Licence, and Prof. Michael W. George
Angewandte Chemie International Edition, Vol. 57, Issue 39, 2018

Cyrene as a bio-based solvent for HATU mediated amide coupling
Kirsty L. Wilson, Jane Murray, Craig Jamieson, and Allan J. B. Watson
Organic & Biomolecular Chemistry, Issue.16, pp. 2851-2854, 2018

A Novel Greener Alternative Scoring Matrix - Based on Twelve Principles of Green Chemistry
*Ettigounder Samy Ponnusamy and Jeffrey Whitford 
International Journal of Information Research and Review Vol. 05, Issue, 01, pp.5147-5153, January, 2018

DOZN™ – A Quantitative Green Chemistry Evaluator
Blog Post created by ACS Green Chemistry Institute® on Aug 16, 2017
Contributed by Samy Ponnusamy, Ph.D., Fellow, Green Chemistry, MilliporeSigma; and Jeffrey Whitford, Head of Corporate Responsibility and Branding, MilliporeSigma

A New Greener Alternative Scoring Matrix Based on Twelve Principles of Green Chemistry
*Ettigounder (Samy) Ponnusamy and Jeffrey Whitford
Asian Journal of Science and Technology Vol. 09, Issue, 01, pp.7312-7318, January, 2018

CYRENE™: A New Bio-based Dipolar Aprotic Solvent
Blog Post created by ACS Green Chemistry Institute® on Feb 21, 2018
Contributed by Jane Murray, Ph.D., Global Head of Green Chemistry, Merck KGaA (MilliporeSigma)

A Method for Assessing Greener Alternatives between Chemical Products Following the 12 Principles of Green Chemistry
- ACS Sustainable Chem. Eng. 2017, 5, 2927-2935
Ashley DeVierno Kreuder,*,‡ Tamara House-Knight,‡ Jeffrey Whitford,† Ettigounder Ponnusamy,† Patrick Miller,† Nick Jesse,† Ryan Rodenborn,† Shlomo Sayag,§ Malka Gebel,§ Inbal Aped,§ Israel Sharfstein,§ Efrat Manaster,§ Itzhak Ergaz,§ Angela Harris,‡ and Lisa Nelowet Grice‡

Green Chemistry: Today (and Tomorrow)
James Clark

Ionic Liquids – Solvents of the Future?
Robin Rogers and Kenneth Seddon

Sigma-Aldrich® Named to Newsweek's 2015 Green Rankings
PR Newswire

Chemical Footprinting: Identifying Hidden Liabilities in Manufacturing Consumer Products
Lindsey Konkel

Green Chemistry’ Products Show Higher Sales Growth
Vikas Vij

Top 10 Green Companies in the U.S. 2015

Exploiting intramolecular hydrogen bonding for the highly (Z)-selective & metal free synthesis of amide substituted β-aminoenones
- Green Chem., 2017,19, 2541-2545
Palaniraja Subramaniam,* Chandrasekaran Ramasubbu and Selvaraj Athiramu



Green Chemistry: Principles and Practice
Paul Anastas & Nicolas Eghbali

Green Chemistry, and Sustainability: A Review of Areas of Convergence
Paul Schulte, Lauralynn McKernan, Donna Heidel, Andrea Okun, Gary Dotson, Thomas Lentz, Charles Geraci, Pamela Heckel & Christine Branche, Occupational Safety and Health

Minimize Wastes from Specialty Chemical Processes
Jeffrey Mueller & Michael Cipullo

Designing endocrine disruption out of the next generation of chemicals
T. Schug, R. Abagyan, B. Blumberg, T. Collins, D. Crews, P. DeFur, S. Dickerson, T. Edwards, A. Gore, L. Guillette, T. Hayes, J. Heindel, A. Moores, H. Patisaul, T. Tal, K. Thayer, L. Vandenberg, J. Warner, C. Watson, F. vom Saal, R. Zoeller, K. O'Brien and J. Myers

Polylactides - Chemistry, Properties and Green Packaging Technology: A Review
Jasim Ahmed and Sunil Varshney

Replacement of Dichloromethane within Chormatographic Purification: A Guide to Alternative Solvents
Donna MacMillan, Jane Murray, Helen Sneddon, Craig Jamieson and Allan Watson

Evaluation of Alternative Solvents in Common Amide Coupling Reactions: Replacement of Dichloromethane and N,N-Dimethylformamide
Donna MacMillan, Jane Murray, Helen Sneddon, Craig Jamieson and Allan Watson

Glycerol as a Sustainable solvent for Green Chemistry
Yanlong Gu and Francois Jerome

A Review of Ionic Liquids, Their Limits and Applications
Khashayar Gandhi

Ionic Liquid as Useful Media for Dissolution, Derivatization, and Nanomaterial Processing of Chitin
Jun-Ichi Kadokawa

Aqueous-Phase, Palladium-Catalyzed Suzuki Reactions under Mild Conditions
Yueqin Cai, Gonghua Song, Zhongyuan Wu and Jiawei Zhang

A Review of New Developments in the Friedek-Crafts Alkylation – From Green Chemistry to Asymmetric Catalysis
Magnus Rueping and Boris Nachtsheim

An Efficient and Green Route to Synthesize Azo Compounds through Methyl Nitrite
Kejie Cai, Hongqiang He, Yuwei Chang and Weiming Xu

Green Chemistry with Nanocatalysts
John Glaser

Separable Catalysts in One-Pot Syntheses for Greener Chemistry
Raed Abu-Reziq, Dashan Wang, Michael Post and Howard Alper

Green Chemistry by Nano-catalysis
Vivek Polshettiwar and Rajender Varma

Study on Hydrogen Production System by Coupling with Dye-sensitized Solar Cells
Di Gu, Hongwen Gu, Yanji Zhu, Chuang Zhang and Dianxu Zhang

Material-Efficient Utlization of Waste Oils – Biodegradability and other Chemical Properties of Vegetable Recycling Oils
Hanna Prokkola, Toivo Kuokkanen and Ulla Lassi

Significance of nanotechnology in Food Industry
C. Chellaram, G. Murugaboopathi, A. John, R. Sivakumar, S. Ganesan, S. Krithika and G. Priya

Applying Flow Chemistry: Methods, Materials, and Multi-step Synthesis
D. Tyler McQuade and Peter Seeberger

Fatty acids based transparent polyurethane films and coatings
Sandip Rajput, Dillip Hundiwale, Pramod Mahulikar and Vikas Gite

Safety/Hazard Indices: Completion of a Unified Suite of Metrics for the Assessment of Greenness for Chemical Reactions and Synthesis Plans
John Andraos

Eco-footprint: a new tool for the “Made in Chimex” considered approach
Lucie Leseurre, Cécilia Merea, Sébastien Duprat de Paule and Alain Pinchart

Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation
Vikas V. Gite

A Simplified Green Chemistry Approach to the Biginelli Reaction using Grindstone Chemistry
Pramod P. Mahulikar

A Greener Approach for Synthesis of Functionalized Polyolefins by Introducing Reactive Functionality into Ethylene Copolymers
Dilip G. Hundiwale

Peer Reviewed: Applying the Principles of Green Engineering to Cradle-to-Cradle Design
William McDonough, Michael Braungart, Paul Anastas and Julie Zimmerman

Identifying and designing chemicals with minimal acute aquatic toxicity
Jakub Kostala , Adelina Voutchkova-Kostalb , Paul T. Anastasc , and Julie Beth Zimmerman

Plastics additives and green chemistry
Evan S. Beach, Brian R. Weeks, Rebecca Stern, and Paul T. Anastas

Opportunities for greener alternatives in chemical formulations
P. G. Jessop, F. Ahmadpour, M. A. Buczynski, T. J. Burns, N. B. Green II, R. Korwin, D. Long, S. K. Massad, J. B. Manley, N. Omidbakhsh, R. Pearl, S. Pereira, R. A. Predale, P. G. Sliva, H. VanderBilt, S. Weller and M. H. Wolf

Strategies to enhance CO2 capture and separation based on engineering absorbent materials
Xiaoqing Lu, Dongliang Jin, Shuxian Wei, Zhaojie Wang, Changhua An and Wenyue Guo

A universal halogen-free solvent system for highly efficient polymer solar cells
Wenchao Zhao, Long Ye, Shaoqing Zhang, Mingliang Sun and Jianhui Hou

A green and sustainable approach to utilize bioionic liquids for the selective precipitation of high purity agarose from an agarophyte extract
Mukesh Sharma, Jai Prakash Chaudhary, Dibyendu Mondal, Ramavatar Meena, and Kamalesh Prasad

Using the gravitational energy of water to generate power by separation of charge at interfaces
Yajuan Sun, Xu Huang and Siowling Soh

What causes extended layering of ionic liquids on the mica surface?
Xiao Gong, Andrew Kozbial and  Lei Li

An integrated methodology for the assessment of environmental health implications during thermal decomposition of nano-enabled products
Georgios A. Sotiriou, Dilpreet Singh, Fang Zhang, Wendel Wohlleben, Marie-Cecile G. Chalbot, Ilias G. Kavouras and Philip Demokritou

Metal organic frameworks for photo-catalytic water splitting
K. Meyer, M. Ranocchiari and J. A. van Bokhoven

Suzuki cross-coupling in aqueous media
Ina Hoffmann, Bettina Blumenröder, Silvia Onodi neé Thumann, Sabine Dommer and Jürgen Schatz

Green preparation of tuneable carbon–silica composite materials from wastes
Tengyao Jiang, Vitaliy L. Budarin, Peter S. Shuttleworth, Gary Ellis, Christopher M. A. Parlett,  Karen Wilson, Duncan J. Macquarrie and  Andrew J. Hunt

Dihydrolevoglucosenone (Cyrene) as a bio-based alternative for dipolar aprotic solvents
James Sherwood, Mario De bruyn, Andri Constantinou, Laurianne Moity, C. Rob McElroy,a Thomas J. Farmer, Tony Duncan, Warwick Raverty, Andrew J. Hunt and James H. Clark

Green preparation of fluorescent carbon dots from lychee seeds and their application for the selective detection of methylene blue and imaging in living cells
Mingyue Xue, Mengbing Zou, Jingjin Zhao, Zhihua Zhan and Shulin Zhao

Renewable pyridinium ionic liquids from the continuous hydrothermal decarboxylation of furfural-amino acid derived pyridinium zwitterions
Sarah Kirchhecker, Steffen Tröger-Müller, Sebastian Bake, Markus Antonietti, Andreas Taubert and Davide Esposito

 Green Chemistry Resources

ACS GCI Pharmaceutical Roundtable Solvent Selection Guide
ACS GCI Pharmaceutical Roundtable

GSK Solvent Selection Guide 2009

Sanofi’s Solvent Selection Guide: A Step Toward More Sustainable Processes
Denis Prat, Olivier Pardigoin, Hans-Wolfram Flemming, Sylvie Letestu, Veronique Ducandas, Pascal Isnard, Eberhard Guntrum, Thomas Senac, Stephane Ruisseau, Paul Cruciani and Patrik Hosek

Using the Right Green Yardstick: Why Process Mass Intensity is used in the Pharmaceutical Industry to drive more Sustainable Processes
Concepcion Jimenez-Gonzales, Celia Ponder, Quirinus Broxterman and Julie Manley

Incorporating Green Chemistry Concepts into Mobile Chemistry Applications and Their Potential Uses
Sean Ekins, Alex M. Clark, and Antony J. Williams

Fundamentals of green chemistry: efficiency in reaction design
Roger A. Sheldon

Micellar Reaction System Proven On Kilogram Scale
Green Chemistry: Designer surfactant enables standard organic reactions to proceed in water with low environmental impact
By Stephen K. Ritter, Chemical & Engineering News, Volume 93 Issue 47 | p. 26 | 
Issue Date: November 30, 2015

 Product Information

Literature highlighting greener product, service and packaging options



  • Updating and further expanding GSK's solvent sustainability guide, Catherine M. Alder, John D. Hayler, Richard K. Henderson, Aniko M. Redman, Lena Shukla, Leanna E. Shuster and Helen F. Sneddon, Green Chemistry, 2016, 18, 3879 - 3890.