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Cell Culture

Cyclodextrin Solubility Table

Table includes the solubility of common cell culture components in water and in a solution of 2-Hydroxylpropyl β-cyclodextrin. Cyclodextrin is a non-toxic compound useful for its ability to solubilize fat soluble vitamins and hormones.

Complete list of cell culture grade cyclodextrins

 

Compound Solubility in Water
(mg/ml)
Solubility in 45% w/v 2-Hydroxylpropyl
β-cyclodextrin (mg/ml)
Solubility
Enhancement
Acetazolamide 0.7 17 24
6,7-ADTN HBr 0.56 5.6 10
R(–)-N-Allylnorapomorphine HBr 0.3 1.6 5.5
p-Aminoclonidine HCl 0.43 1.4 3.3
(±)-p-Aminoglutethimide 0.16 1.2 7.5
R(+)-Atenolol <0.01 6 >600
S(–)Atenolol <0.01 6 >600
Butaclamol 0.25 5.4 21
Chloramphenicol 2.5 53 21
4'-Chlordiazepam <0.01 1.5 >150
Chlorthalidone 0.12 8 67
CNQX <0.10 0.8 7.5
Codeine sulfate 3.3 4.3 1.3
CV-1808 <0.07 3.6 54
8-Cylclopentyl-1,3-p-sulfophenylxanthine <0.20 0.8 4
Dexamethasone <0.01 24 3000
Diazepam 0.05 5 100
Digoxin 0.07 52 743
7,9-Dimethyluric acid <0.01 0.4 >36
7,9-Dimethylxanthine 0.75 1.4 1.9
3,5-Dinitrocatechol 0.17 2.8 16.5
1,3-Dipropyl-8-p-sulfophenylxanthine 0.43 6.8 16
DNQX <0.10 1.9 7.6
(S)-ENBA <0.09 2.8 >30
Estradiol <0.01 21 5250
FG-7142 0.07 1.8 27
Furosemide 0.07 1 14
L-Glutamic acid HCl 3.3 8.7 2.6
L-Glutamic acid diethyl ester HCl 3.3 8.7 2.6
Glutethimide 0.26 6 23
Haloperidol <0.20 0.4 2.3
Hexahydro-sila-difenidol HCl <0.01 5.7 >570
Hexahydro-sila-difenidol HCl, p-fluoro analog <1.50 >14 >9.3
Hydrocortisone 0.28 24 86
6-Hydroxydopamine HBr 3.3 5.3 1.6
3-Hydroxymethyl-ß-carboline <0.20 0.4 2.5
Indomethacin 0.02 3 150
Iodotubercidin <0.16 0.9 >5.8
Isobutylmethylxanthine 0.3 0.2 10
(–)-MDO-NPA HCl 1.5 4.1 2.7
Methotrexate 0.04 8 178
2-Methylthio ATP 1.5 3.3 2.2
Naltrindole HCl 0.1 2.2 22
Quabain 12.2 61 5
Papaverine HCl <0.25 4 >16
2-Phenylaminoadenosine <0.01 3.6 >360
Phenytoin 0.02 7 350
R(–)-PIA 0.3 1.6 5.3
S(+)-PIA 1.2 5 4.2
Pirenperone <0.19 0.8 >4.1
Prochlorperazine 0.25 2.3 9.2
Progesterone 0.02 39 2600
DL(±)-Propranolol 3.3 8 2.4
(–)-Quisqualic acid 0.52 1.3 2.5
Ranitidine HCl 1.8 7 3.9
Ro 15-4513 <0.01 0.8 >80
Ro 20-1724, PDE inhibitor <0.01 5 >500
Ro 41-0960, COMT inhibitor <0.70 1 >1.4
Ryanodine <0.14 1.3 >9.3
SKF-83566 HCl <0.01 14 >1400
Spiperone HCl 0.2 2 10
Sulpride <0.21 8 >38
Testosterone 0.03 30 1154
Tetrahydrocannabinol <0.01 2 455
Veratridine <1 >2 >2
Vitamin A 0.01 5 500
Vitamin D <0.23 8 >35

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