Table includes the solubility of common cell culture components in water and in a solution of 2-Hydroxylpropyl β-cyclodextrin. Cyclodextrin is a non-toxic compound useful for its ability to solubilize fat soluble vitamins and hormones.
Complete list of cell culture grade cyclodextrins
| Compound |
Solubility in Water
(mg/ml) |
Solubility in 45% w/v 2-Hydroxylpropyl
β-cyclodextrin (mg/ml) |
Solubility
Enhancement |
| Acetazolamide |
0.7 |
17 |
24 |
| 6,7-ADTN HBr |
0.56 |
5.6 |
10 |
| R(–)-N-Allylnorapomorphine HBr |
0.3 |
1.6 |
5.5 |
| p-Aminoclonidine HCl |
0.43 |
1.4 |
3.3 |
| (±)-p-Aminoglutethimide |
0.16 |
1.2 |
7.5 |
| R(+)-Atenolol |
<0.01 |
6 |
>600 |
| S(–)Atenolol |
<0.01 |
6 |
>600 |
| Butaclamol |
0.25 |
5.4 |
21 |
| Chloramphenicol |
2.5 |
53 |
21 |
| 4'-Chlordiazepam |
<0.01 |
1.5 |
>150 |
| Chlorthalidone |
0.12 |
8 |
67 |
| CNQX |
<0.10 |
0.8 |
7.5 |
| Codeine sulfate |
3.3 |
4.3 |
1.3 |
| CV-1808 |
<0.07 |
3.6 |
54 |
| 8-Cylclopentyl-1,3-p-sulfophenylxanthine |
<0.20 |
0.8 |
4 |
| Dexamethasone |
<0.01 |
24 |
3000 |
| Diazepam |
0.05 |
5 |
100 |
| Digoxin |
0.07 |
52 |
743 |
| 7,9-Dimethyluric acid |
<0.01 |
0.4 |
>36 |
| 7,9-Dimethylxanthine |
0.75 |
1.4 |
1.9 |
| 3,5-Dinitrocatechol |
0.17 |
2.8 |
16.5 |
| 1,3-Dipropyl-8-p-sulfophenylxanthine |
0.43 |
6.8 |
16 |
| DNQX |
<0.10 |
1.9 |
7.6 |
| (S)-ENBA |
<0.09 |
2.8 |
>30 |
| Estradiol |
<0.01 |
21 |
5250 |
| FG-7142 |
0.07 |
1.8 |
27 |
| Furosemide |
0.07 |
1 |
14 |
| L-Glutamic acid HCl |
3.3 |
8.7 |
2.6 |
| L-Glutamic acid diethyl ester HCl |
3.3 |
8.7 |
2.6 |
| Glutethimide |
0.26 |
6 |
23 |
| Haloperidol |
<0.20 |
0.4 |
2.3 |
| Hexahydro-sila-difenidol HCl |
<0.01 |
5.7 |
>570 |
| Hexahydro-sila-difenidol HCl, p-fluoro analog |
<1.50 |
>14 |
>9.3 |
| Hydrocortisone |
0.28 |
24 |
86 |
| 6-Hydroxydopamine HBr |
3.3 |
5.3 |
1.6 |
| 3-Hydroxymethyl-ß-carboline |
<0.20 |
0.4 |
2.5 |
| Indomethacin |
0.02 |
3 |
150 |
| Iodotubercidin |
<0.16 |
0.9 |
>5.8 |
| Isobutylmethylxanthine |
0.3 |
0.2 |
10 |
| (–)-MDO-NPA HCl |
1.5 |
4.1 |
2.7 |
| Methotrexate |
0.04 |
8 |
178 |
| 2-Methylthio ATP |
1.5 |
3.3 |
2.2 |
| Naltrindole HCl |
0.1 |
2.2 |
22 |
| Quabain |
12.2 |
61 |
5 |
| Papaverine HCl |
<0.25 |
4 |
>16 |
| 2-Phenylaminoadenosine |
<0.01 |
3.6 |
>360 |
| Phenytoin |
0.02 |
7 |
350 |
| R(–)-PIA |
0.3 |
1.6 |
5.3 |
| S(+)-PIA |
1.2 |
5 |
4.2 |
| Pirenperone |
<0.19 |
0.8 |
>4.1 |
| Prochlorperazine |
0.25 |
2.3 |
9.2 |
| Progesterone |
0.02 |
39 |
2600 |
| DL(±)-Propranolol |
3.3 |
8 |
2.4 |
| (–)-Quisqualic acid |
0.52 |
1.3 |
2.5 |
| Ranitidine HCl |
1.8 |
7 |
3.9 |
| Ro 15-4513 |
<0.01 |
0.8 |
>80 |
| Ro 20-1724, PDE inhibitor |
<0.01 |
5 |
>500 |
| Ro 41-0960, COMT inhibitor |
<0.70 |
1 |
>1.4 |
| Ryanodine |
<0.14 |
1.3 |
>9.3 |
| SKF-83566 HCl |
<0.01 |
14 |
>1400 |
| Spiperone HCl |
0.2 |
2 |
10 |
| Sulpride |
<0.21 |
8 |
>38 |
| Testosterone |
0.03 |
30 |
1154 |
| Tetrahydrocannabinol |
<0.01 |
2 |
455 |
| Veratridine |
<1 |
>2 |
>2 |
| Vitamin A |
0.01 |
5 |
500 |
| Vitamin D |
<0.23 |
8 |
>35 |
back to top
