Functional Genomics & RNAi




General shRNA FAQs
For general questions regarding Sigma's shRNA product line, please click here. Otherwise please select one of the categories below.

Ordering and Pricing
All of Sigma's shRNA clones can be conveniently ordered on our website. For more information on placing orders or for pricing information, please click here.

Custom Options and Services
Sigma is pleased to offer custom services for customers requiring large volumes or special orders. For more information please click here.

TRC Design and pLKO.1 Vector
The MISSION shRNA clones, designed by the TRC, are pre-cloned into the pLKO.1-Puro vector. This lentiviral vector allows for propagation in bacterial culture and selection of inserts in mammalian cells. For more information about shRNA or vector design, please click here.

Whole-genome TRC shRNA libraries, gene family sets or individual shRNA clones are available in the following three options: lentiviral particles, plasmid DNA and bacterial glycerol stocks. For more information about each of these formats, please select on of the links below.

Experimental Design and Analysis
For common questions regarding experimental design and analysis, or for a list of validated cell types, please select one of the links below.

Advanced RNAi Applications
For more information regarding in vivo applications or use of these products within difficult cell types, please select one of the links below.

ExpressMag®, Transduction Enhancement
The ExpressMag system consists of magnetic beads that are designed to improve the lentiviral delivery of genetic information into target cells that are difficult to transduce. The ExpressMag System has been specifically validated to support the MISSION lentiviral shRNA products. For more information, please click here.

RNAi Glossary
For definitions of commonly used RNAi terminology, please click here.

Have a question you'd like to have answered by an RNAi Expert?
Email us at

Contact Us
For questions about the library, pricing and quotes or other concerns, please e-mail us at:

MISSION is a trademark of Sigma-Aldrich. Label License.

back to top
shRNA Homepage
RNAi Homepage