BioFiles Volume 4, Number 8 — Metabolomics

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Table of Contents


Altered Amino Acid Metabolites in Aging

Muscle loss with aging is associated with significant changes in amino acid metabolism. Nutritional changes in the daily protein intake, provision of excess leucine or exercise may improve activation of translation initiation and muscle protein synthesis. A significant portion of the aged population may not be receiving sufficient sulphur amino acids, which are present between 3% and 6% in proteins. From the two sulphur-containing amino acids only cysteine is synthesized by us and requires a steady supply of sulphur, while methionine cannot be synthesized by humans and has to be supplied by our food. On the other hand, homocysteine, a sulphur-containing amino acid playing a role in one-carbon metabolism, may be involved in geriatric multisystem problems and therefore research in monitoring and lowering homocysteine is of interest. Efforts to assess excitatory amino acid metabolism in a variety of neurodegenerative disorders may be useful for the development of new neuroprotective pharmaceuticals.


Description Product No.
γ-Aminobutyric acid, SigmaUltra, ≥99% A5835
2-Aminoisobutyric acid, 98% 850993
DL-3-Aminoisobutyric acid, 98% 217794
L-Arginine, ≥99.5% (NT) 11009
L-Aspartic acid, ≥99.5% (T) 11189
L-Carnitine inner salt, synthetic, ≥98% C0158
Desmosine chloride, from bovine, 99.5%±0.2% D9439
DL-Homocysteine, ≥95% (titration) H4628
Homovanillic acid H1252
DL-p-Hydroxyphenyllactic acid, ~98% (HPLC) H3253
Melatonin, ≥98% (TLC) M5250
L-Pyroglutamic acid, puriss., ≥99.0% (T) NH 83160
Taurine, ≥99.5% (T) 86329

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