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Aminoalkylated Resins

Chemfiles Volume 3 Article 4

Our (aminomethyl)polystyrene resins are prepared by aminomethylation of unsubstituted polystyrene in order to ensure chemically homogeneous supports, free of any reactive chloromethyl groups. Aminoalkylated resins represent an ideal base for the immobilization of linkers for both Boc- and Fmoc-SPPS and SPOS. Introduction of an appropriate linker carrying a carboxy functionality is accomplished using standard peptide coupling procedures.

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  1. Mitchell, A. R. et al. J. Org. Chem. 1978, 43, 2845.

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