PhenoFluor™: A Deoxyfluorinating Reagent Convenient Enough to Use in the Hood

The functional-group-tolerant, one-step conversion of phenols to aryl fluorides is a highly desirable process. PhenoFluor™, an innovative reagent developed by Ritter and co-workers,1 provides a straightforward method to fluorinate alcohol and phenols without preactivation and regioselectively fluorinate highly functionalized late-stage intermediates. In collaboration with Tobias Ritter, we now offer two convenient formulation of PhenoFluor™ that can be readily used outside of the glovebox.

General Reaction Scheme

PhenoFluor™ is a thermally stable deoxyfluorinating agent that delivers aryl fluorides from phenols in a one-step, high–yield, ipso substitution reaction. The method is operationally simple, regiospecific, scalable, and compatible with a variety of functional groups including amines, aldehydes, and heterocycles. More recently, it was reported that PhenoFluor™ can be used in a Late Stage Functionalization (LSF) strategy by deoxyfluorinating several natural products and drug-like molecules in a highly regioselective fashion.

Representative Substrate Scope



PhenoFluor is a trademark of SciFluor Life Sciences, LLC.

Sure/Seal is a trademark of Merck KGaA, Darmstadt, Germany and/or its affiliates.

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