Protein of the Month


Protein of the Month, February: Tev Protease, Expressed in E. Coli
Origin: Tobacco Etch Virus (TEV) causes dwarfing of plants and wilting of their leaves in plants such as tobacco or tomato.. The virus proteins are organized in a polyprotein that is specifically cleaved.
Action: The protease specificity helps the virus process its polyprotein to functional units. The specificity is also useful to cleave engineered recombinant fusion proteins.
How: The TEV protease is highly specific to recognition sequence Glu-Asn-Leu-Tyr-Phe-Gln/Gly.
Did you know? TEV protease with GST and His tags allows both the protease and the cleaved target tag to be removed at the same time.
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