NCSTN
nicastrin
Sinónimos:
APH2
Especie:
Human NCSTN (23385), Mouse Ncstn (59287), Rat Ncstn (289231), domestic cat NCSTN (101090586), sheep NCSTN (101120457), domestic guinea pig Ncstn (100731821), cow NCSTN (514929), chicken NCSTN (426905), naked mole-rat Ncstn (101718052), Zebrafish ncstn (494449) ...Más
ID UniProtKB:
ID del gen:
- Human(23385) Summary: This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
- Mouse(59287) nicastrin
- Rat(289231) nicastrin
- domestic cat(101090586) nicastrin
- sheep(101120457) nicastrin
- domestic guinea pig(100731821) nicastrin
- cow(514929) nicastrin
- chicken(426905) nicastrin
- naked mole-rat(101718052) nicastrin
- Zebrafish(494449) nicastrin
- dog(488638) nicastrin
- Horse(100058515) nicastrin
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Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
Anticuerpo anti-nicastrina, ascites fluid, clone 9C3, Chemicon®,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
KD-Validated Anti Nicastrin Antibody, clone 23GB1040, Rabbit Monoclonal, clone 23GB1040, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reactividad de especies
human, rat
Aplicación
flow cytometry
immunofluorescence
western blot
immunofluorescence
western blot