ATM
ataxia telangiectasia mutated
Synonimy:
AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
Gatunek:
Human ATM (472), Mouse Atm (11920), Rat Atm (300711), Thale Cress ATM (823975), Zebrafish atm (403064), chicken ATM (395401), dog ATM (479450), domestic cat ATM (101089291), Horse ATM (100061765), cow ATM (526824) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(472) Summary: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
- Mouse(11920) ataxia telangiectasia mutated homolog (human)
- Rat(300711) ataxia telangiectasia mutated
- Thale Cress(823975) serine/threonine-protein kinase ATM
- Zebrafish(403064) ataxia telangiectasia mutated
- chicken(395401) ataxia telangiectasia mutated
- dog(479450) ataxia telangiectasia mutated
- domestic cat(101089291) ataxia telangiectasia mutated
- Horse(100061765) ataxia telangiectasia mutated
- cow(526824) ataxia telangiectasia mutated
- sheep(101105847) ataxia telangiectasia mutated
- domestic guinea pig(100717983) ataxia telangiectasia mutated
- naked mole-rat(101718948) ataxia telangiectasia mutated
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-ATM phosphoSer1981 Antibody, clone 10H11.E12, clone 10H11.E12, Chemicon®, from mouse,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Przeciwciało anty-fosfoATM (Ser1981), klon 10H11.E12, clone 10H11.E12, Upstate®, from mouse,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunocytochemistry
immunofluorescence
immunoprecipitation (IP)
western blot
immunofluorescence
immunoprecipitation (IP)
western blot
Przeciwciało anty-fosfoATM (Ser1981), klon 10H11.E12, wolne od wodobrzusza, clone 10H11.E12, from mouse,
Reaktywność gatunkowa
human, mouse
Zastosowanie
ELISA
immunocytochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunoprecipitation (IP)
western blot
Przeciwciało anty-fosfoATM-S1981wytwarzane u królika, ,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
western blot
western blot
Proteins
Numer produktu
Opis
Gatunek