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BCL2L1

BCL2-like 1

Synonimy:
BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(598) Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
  • Mouse(12048) BCL2-like 1
  • Rat(24888) Bcl2-like 1
  • Domestic Rabbit(100008875) BCL2-like 1
  • domestic guinea pig(100730495) BCL2-like 1
  • Zebrafish(114401) bcl2-like 1
  • cow(282152) BCL2-like 1
  • domestic cat(493701) BCL2-like 1
  • chicken(373954) BCL2-like 1
  • dog(403618) BCL2-like 1
  • sheep(443061) BCL2-like 1
  • naked mole-rat(101713410) BCL2-like 1

Custom & Knockdown Gene Products

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-Bcl-XL and BclXs Antibody, clone 7B2.5, clone 7B2.5, Chemicon®, from mouse,
Reaktywność gatunkowa
human
Zastosowanie
flow cytometry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-BCL-XL antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunofluorescence

immunohistochemistry

western blot
Monoclonal Anti-BCL2L1 antibody produced in mouse, clone 3E2-2A5, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
immunofluorescence

proximity ligation assay

western blot
Anti-phospho-BCL-XL (pSer62) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry

western blot
Przeciwciało anty-Bcl-XL, NT, klon 7D9, clone 7D9, Chemicon®, from mouse,
Reaktywność gatunkowa
mouse
Zastosowanie
flow cytometry
immunofluorescence

Proteins

Numer produktu
Opis
Gatunek
Bcl-xL Active human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human BCL2L1,
Gatunek
human
MISSION® esiRNA, targeting mouse Bcl2l1,
Gatunek
mouse