CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
Sinónimos:
CP7A, CYP7, CYPVII
Especie:
Human CYP7A1 (1581), Mouse Cyp7a1 (13122), Rat Cyp7a1 (25428), domestic guinea pig Cyp7a1 (100337633), Domestic Rabbit CYP7A1 (100328551), dog CYP7A1 (486962), chicken CYP7A1 (414834), cow CYP7A1 (510507)
ID UniProtKB:
ID del gen:
- Human(1581) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]
- Mouse(13122) cytochrome P450, family 7, subfamily a, polypeptide 1
- Rat(25428) cytochrome P450, family 7, subfamily a, polypeptide 1
- domestic guinea pig(100337633) cholesterol 7-alpha-hydroxylase
- Domestic Rabbit(100328551) cytochrome P450, family 7, subfamily A, polypeptide 1
- dog(486962) cytochrome P450, family 7, subfamily A, polypeptide 1
- chicken(414834) cytochrome P450, family 7, subfamily A, polypeptide 1
- cow(510507) cytochrome P450, family 7, subfamily A, polypeptide 1
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Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
Anticuerpo anti-Cyp7a1, clon 15B9.1, clone 15B9.1, from mouse,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot
Anti-CYP7A1 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunohistochemistry
Small Molecule - Inhibitor
Número de producto
Descripción
Especie
Ketoconazole, 99.0-101.0% (EP, titration), meets EP testing specifications,
Especie
mouse, human, rat