DENND1C
DENN/MADD domain containing 1C
Synonyms:
FAM31C
Species:
Human DENND1C (79958), Mouse Dennd1c (70785), Rat Dennd1c (363326), cow DENND1C (511230), sheep DENND1C (101105327), Domestic Rabbit DENND1C (100349052), domestic cat DENND1C (101096290), naked mole-rat Dennd1c (101722169), Horse DENND1C (100065730), dog DENND1C (485019)
UniProtKB ID:
Gene ID:
- Human(79958) Summary: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]
- Mouse(70785) DENN/MADD domain containing 1C
- Rat(363326) DENN/MADD domain containing 1C
- cow(511230) DENN/MADD domain containing 1C
- sheep(101105327) DENN/MADD domain containing 1C
- Domestic Rabbit(100349052) DENN/MADD domain containing 1C
- domestic cat(101096290) DENN/MADD domain containing 1C
- naked mole-rat(101722169) DENN/MADD domain containing 1C
- Horse(100065730) DENN/MADD domain containing 1C
- dog(485019) DENN/MADD domain containing 1C
- domestic guinea pig(100720914) DENN/MADD domain containing 1C
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