Przejdź do zawartości
Merck

GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

Synonimy:
DMRV, GLCNE, IBM2, NM, Uae1
Gatunek:
Human GNE (10020), Mouse Gne (50798), Rat Gne (114711), Zebrafish gne (393857), chicken GNE (427285), dog GNE (481607), Horse GNE (100067216), domestic cat GNE (101098411), sheep GNE (101110735), cow GNE (782201) ...Więcej
Identyfikator UniProtKB:
Q9Y223, A6PZH2, A6PZH3, A7UNU7, B2R6E1, B7Z372, B7Z428, D3DRP7
Identyfikator genu:
  • Human(10020) Summary: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Mouse(50798) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Rat(114711) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Zebrafish(393857) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • chicken(427285) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • dog(481607) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Horse(100067216) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • domestic cat(101098411) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • sheep(101110735) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • cow(782201) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Domestic Rabbit(100340455) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • naked mole-rat(101705910) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • domestic guinea pig(100731383) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
HPA027258
Anti-GNE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
immunohistochemistry
western blot
HPA007045
Anti-GNE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
immunohistochemistry
SAB6012080
Anti GNE Antibody, clone 23GB5560, Rabbit Monoclonal, clone 23GB5560, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reaktywność gatunkowa
human
Zastosowanie
western blot

esiRNA

Numer produktu
Opis
Gatunek
EHU019551
MISSION® esiRNA, targeting human GNE,
Gatunek
human
EMU057121
MISSION® esiRNA, targeting mouse Gne,
Gatunek
mouse