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Merck

GRIA4

glutamate receptor, ionotropic, AMPA 4

Synonyms:
GLUR4, GLUR4C, GLURD, GluA4
Species:
UniProtKB ID:
Gene ID:
  • Human(2893) Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
  • Mouse(14802) glutamate receptor, ionotropic, AMPA4 (alpha 4)
  • Rat(29629) glutamate receptor, ionotropic, AMPA 4
  • sheep(443274) glutamate receptor, ionotropic, AMPA 4
  • domestic cat(101087003) glutamate receptor, ionotropic, AMPA 4
  • chicken(396137) glutamate receptor, ionotropic, AMPA 4
  • domestic guinea pig(100728256) glutamate receptor, ionotropic, AMPA 4
  • cow(529904) glutamate receptor, ionotrophic, AMPA 4
  • Horse(100061561) glutamate receptor, ionotropic, AMPA 4
  • dog(489427) glutamate receptor, ionotropic, AMPA 4
  • naked mole-rat(101698538) glutamate receptor, ionotropic, AMPA 4

Custom & Knockdown Gene Products

Small Molecule - Agonist

Product Number
Description
Species
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Topiramate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Topiramate, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human
Topiramate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Topiramate, United States Pharmacopeia (USP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Glutamate Receptor 4 Antibody, Chemicon®, from rabbit,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot

Small Molecule - Blocker

Product Number
Description
Species
Topiramate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Topiramate, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human