HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
Synonimy:
LDLCQ3
Gatunek:
Human HMGCR (3156), Mouse Hmgcr (15357), Rat Hmgcr (25675), chicken HMGCR (395145), fruit fly Hmgcr (42803), sheep HMGCR (101108919), naked mole-rat Hmgcr (101717005), domestic guinea pig Hmgcr (100726509), cow HMGCR (407159), Horse HMGCR (100065577) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
- Mouse(15357) 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
- Rat(25675) 3-hydroxy-3-methylglutaryl-CoA reductase
- chicken(395145) 3-hydroxy-3-methylglutaryl-CoA reductase
- fruit fly(42803) HMG Coenzyme A reductase
- sheep(101108919) 3-hydroxy-3-methylglutaryl-CoA reductase
- naked mole-rat(101717005) 3-hydroxy-3-methylglutaryl-CoA reductase
- domestic guinea pig(100726509) 3-hydroxy-3-methylglutaryl-CoA reductase
- cow(407159) 3-hydroxy-3-methylglutaryl-CoA reductase
- Horse(100065577) 3-hydroxy-3-methylglutaryl-CoA reductase
- domestic cat(101098922) 3-hydroxy-3-methylglutaryl-CoA reductase
- dog(479182) 3-hydroxy-3-methylglutaryl-CoA reductase
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Activity Assay
Numer produktu
Opis
Gatunek
HMG-CoA Reductase Assay Kit, sufficient for 30 assays (1 mL), sufficient for 100 assays (200 μL),
Gatunek
human
Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-HMGCR (internal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
western blot
Anti-HMG-CoA Reductase Antibody, clone IgG-A9, clone IgG-A9, from mouse,
Reaktywność gatunkowa
hamster, human, rat
Zastosowanie
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-HMG-CoA reductase Antibody, from rabbit, purified by affinity chromatography,
Reaktywność gatunkowa
human, primate
Zastosowanie
immunoprecipitation (IP)
western blot
western blot
Monoklonalny anty-HMGCR, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0260, purified immunoglobulin, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
western blot
Anti-HMGCR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
Small Molecule - Inhibitor
Numer produktu
Opis
Gatunek
Simvastatin for system suitability CRS, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
Proteins
Numer produktu
Opis
Gatunek