HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
Synonyme:
LDLCQ3
Spezies:
Human HMGCR (3156), Mouse Hmgcr (15357), Rat Hmgcr (25675), chicken HMGCR (395145), fruit fly Hmgcr (42803), sheep HMGCR (101108919), naked mole-rat Hmgcr (101717005), domestic guinea pig Hmgcr (100726509), cow HMGCR (407159), Horse HMGCR (100065577) ...Mehr
UniProtKB-ID:
Gen-ID:
- Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
- Mouse(15357) 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
- Rat(25675) 3-hydroxy-3-methylglutaryl-CoA reductase
- chicken(395145) 3-hydroxy-3-methylglutaryl-CoA reductase
- fruit fly(42803) HMG Coenzyme A reductase
- sheep(101108919) 3-hydroxy-3-methylglutaryl-CoA reductase
- naked mole-rat(101717005) 3-hydroxy-3-methylglutaryl-CoA reductase
- domestic guinea pig(100726509) 3-hydroxy-3-methylglutaryl-CoA reductase
- cow(407159) 3-hydroxy-3-methylglutaryl-CoA reductase
- Horse(100065577) 3-hydroxy-3-methylglutaryl-CoA reductase
- domestic cat(101098922) 3-hydroxy-3-methylglutaryl-CoA reductase
- dog(479182) 3-hydroxy-3-methylglutaryl-CoA reductase
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Activity Assay
Produktnummer
Beschreibung
Spezies
HMG-CoA Reductase Assay Kit, sufficient for 30 assays (1 mL), sufficient for 100 assays (200 μL),
Spezies
human
Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-HMG-CoA-Reduktase-Antikörper, from rabbit, purified by affinity chromatography,
Speziesreaktivität
human, primate
Anwendung
immunoprecipitation (IP)
western blot
western blot
Monoclonal Anti-HMGCR antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0259, purified immunoglobulin, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
western blot
Anti-HMGCR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
Monoclonal Anti-HMGCR antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0260, purified immunoglobulin, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
western blot
Anti-HMGCR (internal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
western blot
Small Molecule - Inhibitor
Produktnummer
Beschreibung
Spezies
Proteins
Produktnummer
Beschreibung
Spezies