HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
Sinónimos:
LDLCQ3
Especie:
Human HMGCR (3156), Mouse Hmgcr (15357), Rat Hmgcr (25675), chicken HMGCR (395145), fruit fly Hmgcr (42803), sheep HMGCR (101108919), naked mole-rat Hmgcr (101717005), domestic guinea pig Hmgcr (100726509), cow HMGCR (407159), Horse HMGCR (100065577) ...Más
ID UniProtKB:
ID del gen:
- Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
- Mouse(15357) 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
- Rat(25675) 3-hydroxy-3-methylglutaryl-CoA reductase
- chicken(395145) 3-hydroxy-3-methylglutaryl-CoA reductase
- fruit fly(42803) HMG Coenzyme A reductase
- sheep(101108919) 3-hydroxy-3-methylglutaryl-CoA reductase
- naked mole-rat(101717005) 3-hydroxy-3-methylglutaryl-CoA reductase
- domestic guinea pig(100726509) 3-hydroxy-3-methylglutaryl-CoA reductase
- cow(407159) 3-hydroxy-3-methylglutaryl-CoA reductase
- Horse(100065577) 3-hydroxy-3-methylglutaryl-CoA reductase
- domestic cat(101098922) 3-hydroxy-3-methylglutaryl-CoA reductase
- dog(479182) 3-hydroxy-3-methylglutaryl-CoA reductase
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Activity Assay
Número de producto
Descripción
Especie
HMG-CoA Reductase Assay Kit, sufficient for 30 assays (1 mL), sufficient for 100 assays (200 μL),
Especie
human
Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-HMGCR antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0259, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti-HMGCR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Monoclonal Anti-HMGCR antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0260, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti-HMGCR antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
western blot
Anti-HMGCR (internal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
western blot
Small Molecule - Inhibitor
Número de producto
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Especie
Proteins
Número de producto
Descripción
Especie