āļ‚āđ‰āļēāļĄāđ„āļ›āļĒāļąāļ‡āđ€āļ™āļ·āđ‰āļ­āļŦāļē
Merck

LMNA

lamin A/C

Synonyms:
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
āļŠāļēāļĒāļžāļąāļ™āļ˜āļļāđŒ:
UniProtKB ID:
āļĢāļŦāļąāļŠāļĒāļĩāļ™:
  • Human(4000) Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
  • Mouse(16905) lamin A
  • Rat(60374) lamin A/C
  • domestic guinea pig(100735212) lamin A/C
  • chicken(415464) lamin A/C
  • sheep(101107924) lamin A/C
  • cow(404144) lamin A/C
  • domestic cat(101086199) lamin A/C
  • Horse(100057663) lamin A/C
  • dog(480124) lamin A/C
  • Zebrafish(195815) lamin A
  • naked mole-rat(101704567) lamin A/C

āļœāļĨāļīāļ•āļ āļąāļ“āļ‘āđŒāļĒāļĩāļ™āļ•āļēāļĄāļŠāļąāđˆāļ‡āđāļĨāļ°āđāļšāļšāđāļĒāļāļŠāļīāđ‰āļ™

Antibodies

āļŦāļĄāļēāļĒāđ€āļĨāļ‚āļŠāļīāļ™āļ„āđ‰āļē
āļ„āļģāļ­āļ˜āļīāļšāļēāļĒ
āļ„āļ§āļēāļĄāļŠāļēāļĄāļēāļĢāļ–āđƒāļ™āļāļēāļĢāļ•āļ­āļšāļŠāļ™āļ­āļ‡āļ‚āļ­āļ‡āļŠāļēāļĒāļžāļąāļ™āļ˜āļļāđŒ
āļāļēāļĢāđƒāļŠāđ‰āļ‡āļēāļ™
Anti-Lamin A−Atto 647N antibody produced in rabbit, 1.5-3 mg/mL, affinity isolated antibody, buffered aqueous solution,
āļ„āļ§āļēāļĄāļŠāļēāļĄāļēāļĢāļ–āđƒāļ™āļāļēāļĢāļ•āļ­āļšāļŠāļ™āļ­āļ‡āļ‚āļ­āļ‡āļŠāļēāļĒāļžāļąāļ™āļ˜āļļāđŒ
human
āļāļēāļĢāđƒāļŠāđ‰āļ‡āļēāļ™
immunofluorescence
Anti-Lamin A antibody produced in rabbit, affinity isolated antibody,
āļ„āļ§āļēāļĄāļŠāļēāļĄāļēāļĢāļ–āđƒāļ™āļāļēāļĢāļ•āļ­āļšāļŠāļ™āļ­āļ‡āļ‚āļ­āļ‡āļŠāļēāļĒāļžāļąāļ™āļ˜āļļāđŒ
human, mouse, rat
āļāļēāļĢāđƒāļŠāđ‰āļ‡āļēāļ™
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-phospho-Lamin A/C (pSer392) antibody produced in rabbit, affinity isolated antibody,
āļ„āļ§āļēāļĄāļŠāļēāļĄāļēāļĢāļ–āđƒāļ™āļāļēāļĢāļ•āļ­āļšāļŠāļ™āļ­āļ‡āļ‚āļ­āļ‡āļŠāļēāļĒāļžāļąāļ™āļ˜āļļāđŒ
human, mouse, rat
āļāļēāļĢāđƒāļŠāđ‰āļ‡āļēāļ™
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-Mature Lamin A Antibody, clone 3E12, ,
āļ„āļ§āļēāļĄāļŠāļēāļĄāļēāļĢāļ–āđƒāļ™āļāļēāļĢāļ•āļ­āļšāļŠāļ™āļ­āļ‡āļ‚āļ­āļ‡āļŠāļēāļĒāļžāļąāļ™āļ˜āļļāđŒ
human
āļāļēāļĢāđƒāļŠāđ‰āļ‡āļēāļ™
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-Prelamin-A Antibody, clone 3C8, ,
āļ„āļ§āļēāļĄāļŠāļēāļĄāļēāļĢāļ–āđƒāļ™āļāļēāļĢāļ•āļ­āļšāļŠāļ™āļ­āļ‡āļ‚āļ­āļ‡āļŠāļēāļĒāļžāļąāļ™āļ˜āļļāđŒ
mouse
āļāļēāļĢāđƒāļŠāđ‰āļ‡āļēāļ™
immunocytochemistry
immunofluorescence

immunohistochemistry

western blot

esiRNA

āļŦāļĄāļēāļĒāđ€āļĨāļ‚āļŠāļīāļ™āļ„āđ‰āļē
āļ„āļģāļ­āļ˜āļīāļšāļēāļĒ
āļŠāļēāļĒāļžāļąāļ™āļ˜āļļāđŒ
MISSIONÂŪ esiRNA, targeting human LMNA,
āļŠāļēāļĒāļžāļąāļ™āļ˜āļļāđŒ
human