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Merck

NR1H3

nuclear receptor subfamily 1, group H, member 3

동의어:
LXR-a, LXRA, RLD-1
:
UniProtKB ID:
Clone ID:
  • Human(10062) Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Mouse(22259) nuclear receptor subfamily 1, group H, member 3
  • Rat(58852) nuclear receptor subfamily 1, group H, member 3
  • chicken(395221) nuclear receptor subfamily 1, group H, member 3
  • Zebrafish(548341) nuclear receptor subfamily 1, group H, member 3
  • naked mole-rat(101709627) nuclear receptor subfamily 1, group H, member 3
  • domestic guinea pig(100725013) nuclear receptor subfamily 1, group H, member 3
  • Goat(100860906) nuclear receptor subfamily 1, group H, member 3
  • sheep(101116762) nuclear receptor subfamily 1, group H, member 3
  • cow(507176) nuclear receptor subfamily 1, group H, member 3
  • domestic cat(101092889) nuclear receptor subfamily 1, group H, member 3
  • dog(483625) nuclear receptor subfamily 1, group H, member 3

Custom & Knockdown Gene Products

Small Molecule - Agonist

제품 번호
설명
Hyodeoxycholic acid, ≥98%,
human
T0901317, ≥98%,
human

Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-NR1H3 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
immunofluorescence
western blot
Anti-NR1H3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human
응용분야
ChIP
immunohistochemistry

western blot
Anti-NR1H3 antibody produced in rabbit, IgG fraction of antiserum,
종별 반응성
human
응용분야
western blot
Anti-LXR-A antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-LXR alpha Antibody, clone 2B7, clone 2B7, from mouse,
종별 반응성
mouse, rat
응용분야
immunoprecipitation (IP)
western blot

Small Molecule - Mixed Agonist/Antagonist

제품 번호
설명
T0901317, ≥98%,
human

Proteins

제품 번호
설명
LXRα-ligand binding domain (215-667) human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
human
LXR, α, ligand binding domain, GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
human
LXR, α isoform, N-terminal region (1-182), GST tagged β human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
human
LXR, α isoform, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human NR1H3,
human
MISSION® esiRNA, targeting mouse Nr1h3,
mouse