UBQLN1
ubiquilin 1
Synonyms:
DA41, DSK2, PLIC-1, UBQN, XDRP1
Species:
Human UBQLN1 (29979), Mouse Ubqln1 (56085), Rat Ubqln1 (114590), chicken UBQLN1 (427454), naked mole-rat Ubqln1 (101715174), domestic cat UBQLN1 (101098901), dog UBQLN1 (476312), domestic guinea pig Ubqln1 (100725674), Horse UBQLN1 (100052573), cow UBQLN1 (282392)
UniProtKB ID:
Gene ID:
- Human(29979) Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(56085) ubiquilin 1
- Rat(114590) ubiquilin 1
- chicken(427454) ubiquilin 1
- naked mole-rat(101715174) ubiquilin 1
- domestic cat(101098901) ubiquilin 1
- dog(476312) ubiquilin 1
- domestic guinea pig(100725674) ubiquilin 1
- Horse(100052573) ubiquilin 1
- cow(282392) ubiquilin 1
- sheep(100302096) ubiquilin 1
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