Pharma Analysis & QC

Trust our HPLC Columns, Solvents, Reagents, Standards, Filtration products and LC-MS workflow at any stage of your method development and validation. Whether it is ADME/DMPK, Drug Product Formulation, API Stability, Impurity Profiling, Dissolution Testing or USP/EP Monograph testing, we have the expertise to help you feel better about your small molecule, peptide, protein, mAbs, ADCs, or excipient analysis.

Featured Articles


Sigma-Aldrich Technical Article

LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

Antibody-drug conjugates (ADC) represent a rapidly emerging class of biotherapeutic molecules, which harness the specificity of monoclonal antibodies (mAb) to selectively deliver highly potent cytotoxic drugs. Like all biotherapeutics they require significant analytical characterization. A non-toxic ADC surrogate, or “ADC Mimic,” with highly similar physicochemical properties to commercial ADCs provides an excellent molecule to safely drive analytical method development . . .

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Supelco Reporter

Analysis of a Bispecific Monoclonal Antibody Using Size Exclusion Chromatography and Mass Spectrometry

More potent formats of monoclonal antibodies (mAbs), such as bispecific antibodies (bsAbs), are on the rise in the area of biotherapeutics. bsAbs recognize two different epitopes. This dual specificity increases the potency of these molecules compared to mAbs and expands the range of possible applications. bsAbs can be used to redirect T cells to tumor cells, block two different signaling pathways simultaneously, dually target different disease mediators, and deliver payloads to targeted sites . . .

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Supelco Technical Article

3S Reagents for Volumetric Titration

Connect Your Lab
3S is an intelligent packaging solution protected with an originality seal. The cap provides information via Radio-frequency identification or RFID, enabling automated data transfer between the reagent and titration instrument. Intelligent communication for improved performance.

Titration on a new level—wet chemical analysis is made safer and more reliable by 3S Adapter Technology:

Safe chemical handling: minimized risk of contamination through contact-free reagent exchange

Smart connection of chemical consumables: communication between the 3S cap and instrument software via RFID . . .