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Advancements depend on an increased understanding of the tumor cell environment and cancer biological, etiologic, clinical, and genetic heterogeneity. Insights into the causes and mechanisms of cancer development and progression have yielded new methods for cancer prevention, detection, and treatment. Improved detection methods have increased the rate of early detection and contributed to decreased cancer mortality for several cancer types, but a significant gap remains in asymptomatic and population-based screening methods. * * * ## Related Articles - [DNA Damage Response (DDR) Pathway](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cancer-research/dna-damage-response-ddr-pathway) Explore key targets of cancer research and cell signaling research with the DNA damage response (DDR) pathway and do a deep dive into ATM, ATR, and p53 mechanisms involved in DNA damage checkpoints. - [DNA Damage and Repair](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cancer-research/dna-damage-and-repair) DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others. - [Autophagy in Cancer Promotes Therapeutic Resistance](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cancer-research/autophagy-in-cancer-promotes-therapeutic-resistance) We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance - [Atto Dyes for Superior Fluorescent Imaging](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/research-and-disease-areas/cancer-research/atto-dyes-for-superior-fluorescent-imaging) Atto dyes are a series of fluorescent dyes that meet the critical needs of modern fluorescent technologies. - [See All (41)](https://www.sigmaaldrich.com/US/en/search/facet-search?focus=sitecontent&term=facet-search) ## Related Protocols - [Imprint® Methylated DNA Quantification Kit (MDQ1) Protocol](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/genomics/epigenetics/methylated-dna-quantification-kit) Imprint ® Methylated DNA Quantification Kit ([MDQ1](#)) Protocol - [Cancer Stem Cell Tumorsphere Formation Protocol](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/cell-culture-and-cell-culture-analysis/3d-cell-culture/cancer-stem-cell-tumorsphere-formation) Step-by-step tumorpshere formation protocol that can used to generate 3D cancer stem cell spheroids. - [Atto Dyes for Superior Fluorescent Imaging](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/research-and-disease-areas/cancer-research/atto-dyes-for-superior-fluorescent-imaging) Atto dyes are a series of fluorescent dyes that meet the critical needs of modern fluorescent technologies. - [Flow Cytometry Protocol](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/research-and-disease-areas/cancer-research/flow-cytometry) Flow cytometry allows researchers to measure several physical characteristics of cells in suspension, such as cell shape, size, and internal complexity. - [Cultrex® Basement Membrane Extract, Type 2, PathClear® Protocol](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/cell-culture-and-cell-culture-analysis/mammalian-cell-culture/membrane-extract-type-2) Cultrex® Basement Membrane Extract (BME) is a soluble form of basement membrane purified from Engelbreth-Holm-Swarm (EHS) tumor. - [See All (3)](https://www.sigmaaldrich.com/US/en/search/facet-search?focus=sitecontent&term=facet-search) ### Find More Articles and Protocols Enter Keywords Search * * * __Related Applications__ [Cell & Developmental Biology Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/cell-and-developmental-biology-research) Rooted in physiology and biochemistry, cell and development biology features an interdisciplinary approach to understand intracellular and extracellular dynamics. 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