ウェビナー (Webinar)

Webinar:再生工学用ナノ・マイクロ加工ハイドロゲル

高分子化学、ナノテクノロジー、および生物科学の進歩を統合した機能材料は、強力な医学療法を創りだす可能性があります。我々のグループは、細胞の挙動を制御できるハイドロゲル(ヒドロゲル)と呼ばれる含水ポリマーネットワークを用いた組織再生療法を開発することを目指しています。具体的には、天然生体分子とナノ粒子を組み合わせることで、ゲルの化学的、生物学的、機械的および電気的特性を調節する光架橋性ハイブリッドハイドロゲルを開発しました。これらの機能性足場は、幹細胞の所望の細胞型への分化を誘導し、血管を有する心臓または骨組織の形成を指示します。組織機能は構造に大きく依存するため、これら材料の構造を制御するために、マイクロ流体工学、フォトリソグラフィー、バイオプリンティングおよび成形のような微細加工法も用いています。これらの戦略を用いて小型化組織を作製しました。組織の複雑性を創り出すために、我々はまた、小さな組織モジュールをより大きなシステムに構築するための指向性アセンブリ技術を開発しました。このようなアプローチは次世代の再生治療薬や生物医学デバイスの開発につながると期待されています。

録画時間:約66分(日本語字幕付き)

  • ※最初の約30秒は無音状態が続きます。
  • ※開始から約50分以降は質疑応答時間です。日本語字幕はございません。ご了承ください。
Speaker Bio
Ali Khademhosseini, PhD
Professor of Bioengineering, Chemical Engineering and Radiology;
Director of the Center for Minimally Invasive Therapeutics (C-MIT);
Associate director for the California NanoSystems Institute
University of California, Los Angeles
Ali Khademhosseini is a Professor of Bioengineering, and Chemical and Biomolecular Engineering at UCLA Henry Samueli School of Engineering and Applied Science, and at the UCLA Radiological Sciences David Geffen School of Medicine. He is the director of the Center for Minimally Invasive Therapeutics (C-MIT) and associate director for the California NanoSystems Institute at UCLA. He is recognized as a leader in combining micro- and nano-engineering approaches with advanced biomaterials for regenerative medicine applications. In particular, his laboratory has pioneered numerous technologies and materials for controlling the architecture and function of engineered vascularized tissues. He has authored ~500 journal papers (H-index > 95, >33,000 citations) and 60 books/chapters. In addition, he has delivered 300+ invited/keynote lectures. Dr. Khademhosseini’s interdisciplinary research has been recognized by over 40 major national and international awards. He is a recipient of the Presidential Early Career Award for Scientists and Engineers, the highest honor given by the US government for early career investigators. In 2011, he received the Pioneers of Miniaturization Prize from the Royal Society of Chemistry (RSC) for his contribution to microscale tissue engineering and microfluidics. In 2016, he received the Sr. Scientist Award of Tissue Engineering and Regenerative Medicine Society -Americas Chapter (TERMIS-AM) and in 2017 he received the Clemson Award of the Society for Biomaterials. He is also a fellow of the American Institute of Medical and Biological Engineering (AIMBE), Biomedical Engineering Society (BMES), Royal Society of Chemistry (RSC), Fellow of the Biomaterials Sciences and Engineering (FBSE) and American Association for the Advancement of Science (AAAS). Currently, he serves on the editorial board of numerous leading journals as well as an Associate Editor for ACS Nano (IF: 13.3) and a member of NIH BTSS study section. He received his Ph.D. in bioengineering from MIT (2005), and MASc (2001) and BASc (1999) degrees from University of Toronto both in chemical engineering. Read more at: http://www.tissueeng.net/lab/index.php.