Avanti® Polar Lipids: Pure Expertise in Lipids Research Products

You don’t have to be a lipid specialist when you order from someone who is. We’ve partnered with Avanti® Polar Lipids to make high-purity lipids more accessible to researchers around the world. Lipids can be unpredictable and unstable. Choose Avanti® products and stop inferior lipids from jeopardizing your experiments. The Avanti® team has consistently led the industry to create pure lipids, winning many awards along the way. All Avanti® products available on SigmaAldrich.com meet stringent quality and stability control standards.

 Avanti® Polar Lipids

  • Phospholipids
  • Sphingolipid
  • Sterols
  • Fluorescent Lipids
  • Detergents
  • Lipidomics
  • Natural & Synthetic Lipids
  • Bioactive Lipids


  • Coenzyme A & Derivatives
  • Fatty Acid Modified Lipids
  • Headgroup Modified Lipids
  • Stable Isotopes & ESR Probes
  • Polymers & Polymerizable Lipids
  • Cationic Lipids (Transfection)
  • Neutral Lipids
  • Aurora® Gold Probes


Avanti® Polar Lipids sealed glass ampoule packaging

 Immunotherapy & Vaccine Development

Monophosphoryl Lipid A (MPL) Adjuvants

Vaccine adjuvants using heterogeneous monophosphoryl Lipid A (MPL) derived from Salmonella minnesota R595 have proven to be safe and effective at inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines. The Avanti® team revolutionized immunotherapy and vaccine development with the introduction of synthetic MPL derivatives and adjuvant systems. We also offer multiple Avanti® synthetic analogs of MPL containing a single molecular species that are as effective and safe at inducing an immune response as their natural product predecessor.

PHAD®, 3D-PHAD®, and 3D(6A)-PHAD® have been tested extensively in animals using a variety of antigens. In all cases, these adjuvants exhibit a similar activity and safety profile to bacterially-derived MPL.