Adrenergics - Agonists

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A0779 p-Aminoclonidine hydrochloride solid α2-adrenoceptor agonist.
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
B8684 Bambuterol hydrochloride >98% (HPLC), powder β-adrenoceptor agonist; bronchodilator; anti-asthmatic; terbutaline prodrug
Bambuterol hydrochloride is used for prophylaxis and also to treat chronic bronchitis and chronic asthma in pediatrics.
 
C125 (±)-CGP-12177A ≥98% (HPLC), solid β-adrenoceptor nonconventional partial agonist.
human ... ADRB1(153), ADRB2(154), ADRB3(155)
C5976 CL 316,243 hydrate ≥98% (HPLC), powder CL 316,243 is a β3 adrenoceptor agonist; anti-obesity agent.
β Adrenoceptor is expressed in a number of tissues such as heart, adipose tissue, colon and other tissues. It is associated with many different biological functions. β Adrenoceptor fills in as an objective for treating type 2 diabetes, heart failure, cachexia, obesity, metabolic disorder, issues related with bladder, colon and malignant tumor growth. Depression and anxiety can also be treated via β adrenoceptor. CL 316,243 is known to have antidiabetic action via β adrenoceptor. It is a potent stimulator of lipolysis. It also activates β3- adrenoceptors on neurons in hypothalamic areas that are important in the central regulation of appetite.
human ... ADRB3(155)
C5423 Clenbuterol hydrochloride ≥95% Clenbuterol hydrochloride is a β2-adrenoceptor agonist and bronchodilator. It is effective in improving peak expiratory flow rate (PEFR) in asthma patients. Clenbuterol is also a performance-enhancing drug as it stimulates the central nervous system and improves oxygen transport. Clenbuterol elicits cardio protective functionality in patients with dilated cardiomyopathy.
human ... ADRB2(154)
D7815 R(−)-Denopamine ≥98% (HPLC), powder β1-adrenoceptor agonist.
Denopamine is a cardiotonic drug.
human ... ADRB1(153)
D0676 Dobutamine hydrochloride ≥98% Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.
human ... ADRB1(153), ADRB2(154)
E4250 (−)-Epinephrine Adrenoceptor agonist.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)
rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Adrb2(24176), Drd1a(24316), Drd2(24318)
E4375 (−)-Epinephrine (+)-bitartrate salt solid Adrenergic receptor agonist.
Epinephrine is mainly liberated from adrenal medulla in response to stress, that is facilitated through sympathetic fibers.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)
E4642 (±)-Epinephrine hydrochloride Adrenergic receptor agonist.
Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility. It is used in the treatment of acute anaphylaxis. Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)
F1016 Fenoterol hydrobromide β2-adrenoceptor agonist; bronchodilator.
human ... ADRB2(154)
F9552 Formoterol fumarate dihydrate >98% (HPLC) β2-Adrenoreceptor agonist.
Formoterol fumarate dihydrate can be used along with budesonide to treat asthma.
human ... ADRB2(154)
G110 Guanabenz acetate salt powder Centrally acting α2 adrenoceptor agonist; I2 imidazoline binding site ligand; antihypertensive.
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
G1043 Guanfacine hydrochloride ≥98% (HPLC) α-2 noradrenergic receptor agonist.
Guanfacine stimulates the brain postsynaptic α2 adrenergic receptor (AR) and mediates the prefrontal cortical (PFC) neuronal regulation and strengthens their network. Guanfacine improves the density of neuronal dendrites and is useful in treating neuropsychiatric disorders. It modulates the synaptic and cytoskeletal proteins expression in prefrontal cortical (PFC) neurons and may improve hypobaric hypoxia (HH) induced PFC dysfunctions. Guanfacine enhances cognitive function and is recommended for attention deficit hyperactivity disorder (ADHD) therapy.
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
I3639 Isoetharine mesylate salt β-Adrenergic receptor agonist; bronchodilator.
human ... ADRB1(153), ADRB2(154), ADRB3(155)
I5627 Isoprenaline hydrochloride β-adrenoceptor agonist; increases cytosolic cAMP.
human ... ADRB1(153), ADRB2(154), ADRB3(155)
I2760 (−)-Isoproterenol (+)-bitartrate salt powder β-Adrenoceptor agonist; increases cytosolic cAMP.
Isoproterenol functions as an ovine pulmonary vein dilator.
human ... ADRB1(153), ADRB2(154), ADRB3(155)
I6504 (−)-Isoproterenol hydrochloride β-adrenoceptor agonist; increases cytosolic cAMP.
Isoproterenol hydrochloride is useful in post transplantal organ recovery. It exhibits ionotropic and chronotropic effects. With respect to donor heart recovery, isoproterenol hydrochloride decreases peripheral and systemic vascular resistance. Isoproterenol also increases the heart rate.
human ... ADRB2(154)
M2398 Metaproterenol hemisulfate salt β2-adrenoceptor agonist
human ... ADRB2(154)
M4773 Metaraminol (+)-bitartrate salt α-adrenoceptor agonist.
Metaraminol may serve as a false sympathetic transmitter. It is a mixed α - and β-adrenergic agonist.
 
M6524 Methoxamine hydrochloride α1-adrenoceptor agonist.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
M1559 Moxonidine hydrochloride ≥98% α2-adrenoceptor agonist and I1 imidazoline binding site agonist that, in many applications, demonstrates selectivity for the high-affinity I1 imidazoline binding site over the α2-adrenoceptor; antihypertensive. Its analgesic effects appear to be due to its agonist activity at spinal α2C-adrenoceptors.
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), NISCH(11188)
N5504 Naphazoline hydrochloride α-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor.
Naphazoline hydrochloride is a sympathomimetic agent. It is also considered as a conjunctival decongestant.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
A7257 (−)-Norepinephrine ≥98%, crystalline Adrenergic neurotransmitter
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)
rat ... Adra1a(29412), Adra1d(29413), Adra2a(25083), Adrb1(24925), Adrb2(24176), Drd1a(24316), Drd2(24318)
A0937 (±)-Norepinephrine (+)-bitartrate salt Adrenergic neurotransmitter
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)
A9512 L-(−)-Norepinephrine (+)-bitartrate salt monohydrate ≥99%, solid Norepinephrine bitartrate plays an important role in in vivo and in vitro development of pathogenic and indigenous bacteria.
 
O2378 Oxymetazoline hydrochloride ≥99%, solid Oxymetazoline hydrochloride is a partial α2A-adrenoceptor agonist; agonist at 5-HT1A, 5-HT1B, and 5-HT1D serotonin receptors. It is a mixed agonist-antagonist at 5-HT1C serotonin receptors.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), HTR1A(3350), HTR1B(3351), HTR1D(3352)
P6126 (R)-(−)-Phenylephrine hydrochloride powder α1-adrenoceptor agonist.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
P9180 Procaterol hydrochloride β2-adrenoceptor agonist; bronchodilator.
 
R0758 Ritodrine hydrochloride β2-adrenoceptor agonist; relaxes uterine muscle contraction.
human ... ADRB2(154)
S8260 Salbutamol β2-adrenoceptor agonist
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
human ... ADRB2(154)
S5013 Salbutamol hemisulfate salt ≥98% β2-Adrenergic receptor agonist.
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP). Salbutamol is particularly effective in treatment of asthma as it provides immediate relief. Salbutamol is one of the most popular short-acting BA (SABA). It is useful in treating the symptoms of EIB (exercise induced bronchospasm).
human ... ADRB2(154)
S5068   Salmeterol xinafoate ≥98% (HPLC), solid β2-adrenoceptor agonist.
Salmeterol xinafoate is a β2 adrenoceptor agonist with longer lasting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles, stabilizes mast cells and regulates the release of histamine. Salmetrol is particularly effective in treatment of mild asthma, chronic obstructive pulmonary disorder.5,6
human ... ADRB2(154)
S0752 (±)-Synephrine ≥98% α-adrenoceptor agonist, vasoconstrictor.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
T2528 Terbutaline hemisulfate salt Terbutaline is a β-adrenoceptor agonist and is known to function as a bronchodilator. Studies have reported that terbutaline is potent inhibitor of premature labor6.
human ... ADRB1(153), ADRB2(154), ADRB3(155)
T4264 Tetrahydrozoline hydrochloride ≥98% (HPLC) α-adrenoceptor agonist; imidazoline binding site ligand; vasoconstrictor.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
T6950 Tizanidine hydrochloride ≥98% (HPLC), powder α2-adrenoceptor agonist.
Tizanidine hydrochloride is known to function as a skeletal muscle relaxant that acts centrally. Furthermore, this relaxant functions at spinal and supraspinal levels to block excitatory interneurons. This drug is used for the symptomatic relief of spasticity and painful muscle spasms.
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
U104 UK 14,304 UK 14,304 is an α2-adrenoceptor agonist. UK 14,304 inhibits hormone-sensitive lipase (HSL) activity and suppresses lipogenesis in adipose tissue.
human ... ADRA1A(148), ADRA2A(150), ADRA2B(151), ADRA2C(152)
X1126 Xylazine ≥99% α2-adrenoceptor agonist, sedative, muscle relaxant.
Xylazine when used along with ketamine is considered to be a potent and safe anaesthetic in experimental animal. It is known to elevate the hepatic release of glucose, which aggravates to hyperglycemia.
 
X1251 Xylazine hydrochloride ≥99.0% (HPLC) α2-Adrenergic receptor agonist, sedative, muscle relaxant.
Xylazine is used as a sedative in goats as it is safe, active and a cheap drug. It is a centrally acting drug, which exhibits muscle relaxant and analgesic properties.
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)