Adenosines/P2 Nucleotide Receptor - Agonists

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A236 AB-MECA solid High affinity A3 adenosine receptor agonist.
human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
A9251 Adenosine ≥99% Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).
human ... ADA(100), ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), ERBB2(2064), ERBB4(2066)
rat ... Adcy2(81636), Adora1(29290), Adora2a(25369), Adora3(25370)
A111 Adenosine amine congener hydrate solid, ≥98% (HPLC) Potent aqueous-soluble A1 adenosine receptor agonist.
rat ... Adora1(29290)
A5285 Adenosine 5′-diphosphate monopotassium salt dihydrate bacterial, ≥95%, powder P2Y receptor agonist.
human ... HSP90AA1(3320), P2RY1(5028)
A202 N6-2-(4-Aminophenyl)ethyladenosine >95% Potent, non-selective A3 adenosine receptor agonist.
human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
C141 CGS-21680 hydrochloride hydrate solid Adenosine receptor agonist, which possesses selectivity for A2 verses A1 receptors.
human ... ADORA2A(135), ADORA2B(136)
C5134 2-Chloroadenosine 2-Chloroadenosine is an analog of adenosine. It is an adenosine A1 receptor agonist. It might possess anti-oxidant property.
human ... ADORA1(134), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
C9901 N6-Cyclohexyladenosine Selective A1 adenosine receptor agonist.
human ... ADORA1(134)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
C8031 N6-Cyclopentyladenosine solid N6-Cyclopentyladenosine (CPA) is an adenosine derivative and a potent A1 adenosine receptor agonist. It acts as an anticonvulsant and might exhibit protective actions against aminophylline (AMPH)-induced seizures.
human ... ADORA1(134), ADORA2A(135), ADORA3(140)
mouse ... Adora1(11539)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
C1506 Cytidine 5′-triphosphate disodium salt ≥95% Cytidine 5′-triphosphate (CTP) prevents the action of aspartate carbamoyltransferase. This enzyme participates in pyrimidine biosynthesis. Like adenosine triphosphate (ATP), CTP serves as a molecule of high energy. It acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation.
P2X4 purinergic receptor agonist.
E2387 5′-(N-Ethylcarboxamido)adenosine powder Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors.
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)
K3769 KW-3902 ≥98% (HPLC) KW-3902 is an A1 adenosine receptor antagonist and is over 800 fold more selective for an A1 receptor versus the A2A receptor.
M6517 α,β-Methyleneadenosine 5′-triphosphate lithium salt ≥93% (HPLC), solid P2 purinoceptor agonist that is more potent than ATP at the P2X subtype.
human ... P2RX1(5023)
M7510 β,γ-Methyleneadenosine 5′-triphosphate disodium salt ≥95%, solid Selective P2X purinoceptor agonist that is more potent than ATP, but less potent than α, β-methylene-L-adenosine 5′-triphosphate.
P101 2-Phenylaminoadenosine >97%, solid Selective A2 adenosine receptor agonist; potent coronary vasodilator; weak inhibitor of adenosine uptake by rat cerebral cortical synaptosomes.
human ... ADORA2A(135), ADORA2B(136)
rat ... Adora1(29290), Adora2a(25369)
P4532 (−)-N6-(2-Phenylisopropyl)adenosine solid A1 adenosine receptor agonist. Affinity for adenosine receptor is approx. 100× that of the (+)-isomer.
human ... ADORA1(134)
U4125 Uridine 5′-(trihydrogen diphosphate) sodium salt from Saccharomyces cerevisiae 95-100% P2Y receptor agonist.
human ... LPAR4(2846), LTB4R(1241), P2RY1(5028), P2RY10(27334), P2RY11(5032), P2RY12(64805), P2RY13(53829), P2RY14(9934), P2RY2(5029), P2RY4(5030), P2RY5(10161), P2RY6(5031), P2RY8(286530)
U6875 Uridine 5′-triphosphate tris salt Type VI, ≥90% P2Y receptor agonist.
Uridine 5′-triphosphate (UTP) is synthesized from uridine 5′-diphosphate (UDP) in the presence of the enzyme nucleoside diphosphate kinase (NDPK). Plant cells have high uridine as UTP. UTP on amination results in the generation of CTP and is catalysed by enzyme CTP synthetase. UTP acts on the purinergic (P2Y2) receptor and mediates smooth muscle cells (SMCs) mitogenic activation. It also modulates osteopontin expression in SMCs. UTP is a sputum inducer and a promising candidate for assessing the inflammation in respiratory airway.
U6625 Uridine 5′-triphosphate trisodium salt hydrate from yeast, Type III, ≥96% P2Y receptor agonist.
U6750 Uridine 5′-triphosphate trisodium salt hydrate Type IV, ≥93.0% (HPLC) P2Y receptor agonist.
Uridine-5′-Triphosphate (UTP) is a cytosolic nucleotide component of nucleic acids. It serves as a signaling molecule in the extracellular space. Uridine-5′-Triphosphate (UTP) is involved in various pathophysiological responses in the nervous system. UTP also plays a major role in the regeneration process.