Interferes with Cell Membrane Permeability (Ionophores)
Polymyxin B and colistin (polymyxin E) disrupt the cell membrane integrity of Gram-negative bacteria by binding to membrane phospholipids. Eukaryotic cell membranes have phospholipids similar to Gram-negative bacteria, so the polymyxins are most often used clinically as topical antibiotics.

In contrast, the ionophore antibiotics such as monensin and valinomycin tend to be more active against Gram-positive bacteria, which lack the outer cell membranes. Monensin is an ionophore that forms monovalent ion channels in the cell wall of Gram-positive bacteria and allows the free movement of K+ and Na+ ions along their concentration gradients. Valinomycin is a selective K+ ionophore that triggers mitochondrial transition by facilitating the transport of K+ across the mitochondrial membrane. By altering the intracellular cationic environment of the cell, these agents uncouple mitochondrial oxidative metabolism and inhibit cell growth.

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100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem A mobile ion-carrier that forms stable complexes with divalent cations.
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    • 21186 Calcium ionophore III Selectophore™, function tested
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    • C9275 Calcium Ionophore A23187 hemicalcium salt powder
    • C9400 Calcium Ionophore A23187 hemimagnesium salt
    • C6830 Cecropin A ≥97% (HPLC), powder
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    • E4632 Econazole nitrate salt
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    • I1774 Iturin A from Bacillus subtilis ≥95% (HPLC)
    • M7152 Magainin I ≥97% (HPLC)
    • M7402 Magainin II ≥97% (HPLC)
    • H3261 2-Mercaptopyridine N-oxide sodium salt ≥96%
    • 47589-M Mitomycin C, Streptomyces caespitosus - CAS 50-07-7 - Calbiochem
    • M5273 Monensin sodium salt 90-95% (TLC)
    • 46468 Monensin sodium salt hydrate VETRANAL®, analytical standard
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    • N1271 Narasin from Streptomyces auriofaciens ≥98% (HPLC)
    • N7143 Nigericin sodium salt ≥98% (TLC)
    • 481990 Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem Disrupts the membrane potential and stimulates ATPase activity in mitochondria.
    • N5764 Nisin from Lactococcus lactis 2.5% (balance sodium chloride)
    • N2286 Nonactin from Streptomyces griseus, ≥98% (function tested, HPLC)
    • SRP3126 NP-1 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
    • N6261 Nystatin powder, BioReagent, suitable for cell culture
    • N3503 Nystatin ≥4,400 USP units/mg
    • N4014 Nystatin powder, γ-irradiated, BioXtra, suitable for cell culture
    • 475914 Nystatin, Streptomyces noursei - CAS 1400-61-9 - Calbiochem A polyene antifungal antibiotic effective against yeast and mycoplasma.
    • N1638 Nystatin Suspension suspension, 10,000 unit/mL in DPBS, aseptically processed, BioReagent, suitable for cell culture
    • P0053 PGLa
    • P9625 Phenazine methosulfate ≥90% (UV)
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    • P0440 Pimaricin preparation ~2.5% (γ-irradiated Pimaricin), aqueous suspension
    • 81271 Polymyxin B solution 1 mg/mL in H2O, analytical standard
    • P0972 Polymyxin B sulfate meets USP testing specifications
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    • P1004 Polymyxin B sulfate salt
    • P4668 Praziquantel anthelminic, neurogenic
    • 46648 Praziquantel VETRANAL®, analytical standard
    • S4526 Salinomycin from Streptomyces albus, ≥98% (HPLC)
    • 563080-M Salinomycin Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug.
    • S6201 Salinomycin, Ready Made Solution from Streptomyces albus, ≥98% (HPLC)
    • S3523 Surfactin from Bacillus subtilis, ≥98.0% (HPLC)
    • 03907 Tioconazole 97%
    • V0627 Valinomycin ≥98% (TLC), ≥90% (HPLC)
    • 94675 Valinomycin ≥99.0% (TLC)
    • V3639 Valinomycin Ready Made Solution, ~1 mg/mL in DMSO, 0.2 μm filtered
    • 676377 Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem A cyclododecadepsi-peptide ionophore antibiotic.