NOS - Nitric Oxide Inhibitors

Nitric Oxide Inhibitor Products

Nitric Oxide Synthase (NOS) exists in three distinctly different structural isoforms namely neuronal (nNOS), endothelial (eNOS) and inducible (iNOS). Nitric oxide (NO), which is a molecular messenger and is synthesized by nitric oxide synthase (NOS) from L-arginine and molecular oxygen, is responsible for a number of pathological and physiological processes in mammalians. As NOS isozymes are involved in different aspects of signal transduction, NOS inhibitors have found importance in managing hypotensive effects of drugs, ischemic reperfusion injury and inflammatory response to cytokines. Thereby NOS inhibitors are novel therapeutic approach towards various diseases, and can also be used in investigating other biological functions of NO.

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100050 1400W - CAS 214358-33-5 - Calbiochem A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM).
A9834 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine ≥98%
A5879 2-(2-Aminoethyl)isothiourea dihydrobromide
A7009 Aminoguanidine hemisulfate salt ≥98%
A0384 Arcaine sulfate salt
C1625 L-Canavanine ≥98% (TLC), powder, from Canavalia ensiformis
C9758 L-Canavanine sulfate salt ≥99% (TLC), powder
219482 Caveolin-1 Scaffolding Domain Peptide, Cell-permeable - Calbiochem Caveolin-1 Scaffolding Domain Peptide, Cell-permeable, blocks eNOS activity and cellular NO release in vitro and reduces inflammation and tumorigenesis in vivo.
219483 Caveolin-1 Scaffolding Domain Peptide, Cell-permeable, Negative Control - Calbiochem A scrambled caveolin-1 scaffolding domain peptide (C1-SD82-101) fused at the N-terminus to the Antennapedia internalization sequence (43-58).
C8138 Chlorpromazine hydrochloride ≥98% (TLC)
215921 Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).
C1386 Curcumin from Curcuma longa (Turmeric), powder
265005 Dexamethasone - CAS 50-02-2 - Calbiochem Dexamethasone, CAS 50-02-2, is one of the most active and highly stable glucocorticoids. Inhibits the expression of inducible, but not constitutive NOS in vascular endothelial cells (IC50 = 5 nM).
D4268 NG,NG-Dimethylarginine dihydrochloride
311204 NG,N-Dimethyl-L-arginine, Dihydrochloride - Calbiochem NG,NGʹ-Dimethyl-L-arginine, Dihydrochloride, is a cell permeable, endogenous inhibitor of nitric oxide synthesis.
311203 NG,NG-Dimethyl-L-arginine, Dihydrochloride - CAS 65005-57-4 - Calbiochem A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo.
D2926 Diphenyleneiodonium chloride ≥98%
300260 Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS).
I4632 2-Iminobiotin ≥98% (TLC)
I8021 L-N6-(1-Iminoethyl)lysine dihydrochloride
400600 L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride - CAS 159190-44-0 - Calbiochem A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase compared to other arginine analogs such as L-NAME and L-NMMA.
M5250 Melatonin powder, ≥98% (TLC)
444300 Melatonin - CAS 73-31-4 - Calbiochem A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals.
M7033 NG-Methyl-L-arginine acetate salt ≥98% (TLC)
M5171 S-Methyl-L-thiocitrulline acetate salt ≥98% (TLC)
472804 S-Methyl-L-thiocitrulline, Dihydrochloride - CAS 209589-59-3 - Calbiochem A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).
475886 NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of NOS.
482100 L-NIL, Dihydrochloride - Calbiochem A cell-permeable, potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase than for the rat brain constitutive enzyme
490070 Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2 - Calbiochem The Nitric Oxide Synthase, Neuronal Inhibitor I, also referenced under CAS 357965-99-2, controls the biological activity of neuronal Nitric Oxide Synthase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
N5501 Nω-Nitro-L-arginine ≥98% (TLC)
N4770 Nω-Nitro-D-arginine methyl ester hydrochloride
N5751 Nω-Nitro-L-arginine methyl ester hydrochloride ≥98% (TLC), powder
483125-M NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).
484235 p-Nitroblue Tetrazolium Chloride - CAS 298-83-9 - Calbiochem p-Nitroblue Tetrazolium Chloride, CAS 298-83-9, is a NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC50 = 3-4 µM). A well-known scavenger of superoxide anions.
N7778 7-Nitroindazole ≥98%
5295 Polyvinylpyrrolidone - CAS 9003-39-8 - Calbiochem Polymer used as a pharmaceutical aid, complexing agent, and a solubilizer.
P1061 Proadifen hydrochloride analytical standard, ≥95%
548000 1-Pyrrolidinecarbodithioic Acid, Ammonium Salt - CAS 5108-96-3 - Calbiochem Cell permeable. Inhibits the induction of NOS activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells.
567300 SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system.
S2626 Spermidine ≥99% (GC)
S2501 Spermidine trihydrochloride ≥98% (TLC)
56766-M Spermidine, Trihydrochloride - CAS 334-50-9 - Calbiochem Polyamine that plays an important role in the regulation of cellular proliferation and differentiation.
S4264 Spermine suitable for cell culture, BioReagent
S3256 Spermine ≥97%
S2876 Spermine tetrahydrochloride powder or crystals
T2909 Tomatidine hydrochloride ≥85%
T7313 1-[2-(Trifluoromethyl)phenyl]imidazole
W4262 1400W dihydrochloride >98%, solid
691550-M Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin.