NOS - Nitric Oxide Inhibitors

Nitric Oxide Inhibitor Products

Nitric Oxide Synthase (NOS) exists in three distinctly different structural isoforms namely neuronal (nNOS), endothelial (eNOS) and inducible (iNOS). Nitric oxide (NO), which is a molecular messenger and is synthesized by nitric oxide synthase (NOS) from L-arginine and molecular oxygen, is responsible for a number of pathological and physiological processes in mammalians. As NOS isozymes are involved in different aspects of signal transduction, NOS inhibitors have found importance in managing hypotensive effects of drugs, ischemic reperfusion injury and inflammatory response to cytokines. Thereby NOS inhibitors are novel therapeutic approach towards various diseases, and can also be used in investigating other biological functions of NO.

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100050 1400W - CAS 214358-33-5 - Calbiochem A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM).
219482 Caveolin-1 Scaffolding Domain Peptide, Cell-permeable - Calbiochem Caveolin-1 Scaffolding Domain Peptide, Cell-permeable, blocks eNOS activity and cellular NO release in vitro and reduces inflammation and tumorigenesis in vivo., Caveolin-1 scaffolding domain peptide (C1-SD82-101) fused at the N-terminus to the cell-permeable Antennapedia internalization sequence (43-58).
219483 Caveolin-1 Scaffolding Domain Peptide, Cell-permeable, Negative Control - Calbiochem A scrambled caveolin-1 scaffolding domain peptide (C1-SD82-101) fused at the N-terminus to the Antennapedia internalization sequence (43-58).
265005 Dexamethasone - CAS 50-02-2 - Calbiochem Dexamethasone, CAS 50-02-2, is one of the most active and highly stable glucocorticoids. Inhibits the expression of inducible, but not constitutive NOS in vascular endothelial cells (IC50 = 5 nM)., Most active and highly stable glucocorticoid.
300260 Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS).
311203 NG,NG-Dimethyl-L-arginine, Dihydrochloride - CAS 65005-57-4 - Calbiochem A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo.
311204 NG,N-Dimethyl-L-arginine, Dihydrochloride - Calbiochem NG,NGʹ-Dimethyl-L-arginine, Dihydrochloride, is a cell permeable, endogenous inhibitor of nitric oxide synthesis., Cell permeable. Endogenous inhibitor of nitric oxide synthesis in vitro and in vivo. Does not exhibit any significant inhibitory effect on NOS activity.
400600 L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride - CAS 159190-44-0 - Calbiochem A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase compared to other arginine analogs such as L-NAME and L-NMMA.
444300 Melatonin - CAS 73-31-4 - Calbiochem A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals.
472804 S-Methyl-L-thiocitrulline, Dihydrochloride - CAS 209589-59-3 - Calbiochem A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).
475886 NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of NOS.
482100 L-NIL, Dihydrochloride - Calbiochem A cell-permeable, potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase than for the rat brain constitutive enzyme
483125-M NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).
483400-M 7-Nitroindazole - CAS 2942-42-9 - Calbiochem A cell-permeable, reversible and competitive inhibitor of nitric oxide synthase (NOS) with high selectivity for the brain enzyme (IC₅₀ = 710 nM) vs.
484235 p-Nitroblue Tetrazolium Chloride - CAS 298-83-9 - Calbiochem p-Nitroblue Tetrazolium Chloride, CAS 298-83-9, is a NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC50 = 3-4 µM). A well-known scavenger of superoxide anions., NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC₅₀ = 3-4 µM).
490070 Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2 - Calbiochem The Nitric Oxide Synthase, Neuronal Inhibitor I, also referenced under CAS 357965-99-2, controls the biological activity of neuronal Nitric Oxide Synthase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
548000 1-Pyrrolidinecarbodithioic Acid, Ammonium Salt - CAS 5108-96-3 - Calbiochem Cell permeable. Inhibits the induction of NOS activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells.
567300 SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system.
56766-M Spermidine, Trihydrochloride - CAS 334-50-9 - Calbiochem Polyamine that plays an important role in the regulation of cellular proliferation and differentiation.
691550-M Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin.
A9834 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine ≥98%
A5879 2-(2-Aminoethyl)isothiourea dihydrobromide
A7009 Aminoguanidine hemisulfate salt ≥98%
A0384 Arcaine sulfate salt
B2050 3-Bromo-7-nitroindazole ≥98% (TLC), powder
C1625 L-Canavanine ≥98% (TLC), powder, from Canavalia ensiformis
C9758 L-Canavanine sulfate salt ≥99% (TLC), powder
C8138 Chlorpromazine hydrochloride ≥98% (TLC)
C1386 Curcumin from Curcuma longa (Turmeric), powder
D4268 NG,NG-Dimethylarginine dihydrochloride
D2926 Diphenyleneiodonium chloride ≥98%
I4632 2-Iminobiotin ≥98% (TLC)
I8021 L-N6-(1-Iminoethyl)lysine dihydrochloride
M5250 Melatonin powder, ≥98% (TLC)
M7033 NG-Methyl-L-arginine acetate salt ≥98% (TLC)
M5171 S-Methyl-L-thiocitrulline acetate salt ≥98% (TLC)
N5501 Nω-Nitro-L-arginine ≥98% (TLC)
N4770 Nω-Nitro-D-arginine methyl ester hydrochloride
N5751 Nω-Nitro-L-arginine methyl ester hydrochloride ≥98% (TLC), powder
N7778 7-Nitroindazole ≥98%
P1061 Proadifen hydrochloride analytical standard, ≥95%
S2626 Spermidine ≥99% (GC)
S4139 Spermidine suitable for cell culture, BioReagent
S2501 Spermidine trihydrochloride ≥98% (TLC)
S4264 Spermine BioReagent, amorphous semi-solid, suitable for cell culture
S3256 Spermine ≥97%
S2876 Spermine tetrahydrochloride powder
T2909 Tomatidine hydrochloride ≥85%
T7313 1-[2-(Trifluoromethyl)phenyl]imidazole
W4262 1400W dihydrochloride >98%, solid