Crude Collagenase with proteolytic activity inhibitor

Our most active crude collagenase, type XI, contains significant activities of other proteolytic enzymes, including clostripain, caseinase, and a tryptic activity. While this product is highly suited for preparation of pancreatic islets and islet cells, the tryptic activity of the collagenase medium can activate the zymogens of the digestive enzymes produced by pancreatic acinar cells. The addition of trypsin inhibitor to the culture medium from Clostridium histolyticum prevents or greatly reduces the activation of the protease proenzymes stored in the pancreas.

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C6079 Collagenase + protease inhibitor 2-5 FALGPA units/mg solid, ≥800 CDU/mg solid, Suitable for isolation of rat pancreatic islet cells.