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Crude Collagenase For General Use

Crude collagenase preparations come from the culture medium of Clostridium histolyticum, an anaerobic, gram-positive bacterium, commonly found in soil. In addition to collagenase, the culture medium contains as many as six proteases, including clostripain, a caseinase, and a tryptic-like proteinase. The additional proteases with different substrate specificities lead to more complete digestion of collagen fragments and other components of extracellular matrix. We offer unfractionated medium, as well as medium put through a single purification step, equivalent to the 40% ammonium sulfate precipitation described by MacLennan et al (1). Some products come pre-sterilized by filtration for immediate use in cell culture applications.

1. MacLennan, JD, Mandl, I, and Howes, E. Bacterial Digestion of Collagen. J. Clin. Invest. 32, 1317 (1953)

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C0130 Collagenase from Clostridium histolyticum for general use, Type I, 0.25-1.0 FALGPA units/mg solid, ≥125 CDU/mg solid
C1639 Collagenase from Clostridium histolyticum sterile-filtered, for general use, Type I-S, 0.2-1.0 FALGPA units/mg solid, ≥125 CDU/mg solid
C9891 Collagenase from Clostridium histolyticum Type IA, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid, For general use
C5894 Collagenase from Clostridium histolyticum sterile; sterile-filtered, Type IA-S, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid
C2674 Collagenase from Clostridium histolyticum lyophilized powder, ≥125 CDU/mg solid (CDU = collagen digestion units), 0.5-5.0 FALGPA units/mg solid
C9722 Collagenase from Clostridium histolyticum lyophilized powder (from sterile-filtered solution), 0.5-5.0 FALGPA units/mg solid, cell culture tested