Protein kinase C

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19-123-M Staurosporine Staurosporine Streptomyces is a potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases.  
203290 Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem Bisindolylmaleimide I, CAS 133052-90-1, is a cell-permeable, highly selective, reversible inhibitor of protein kinase C (IC50 = 10 nM). Acts on the ATP-binding site of PKC., A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC₅₀ = 10 nM) that is structurally similar to staurosporine. C₂₅H₂₄N₄O₂
203291 Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem An enhanced water-soluble form of Bisindolylmaleimide I. C₂₅H₂₄N₄O₂ · HCl
203292 Bisindolylmaleimide II - CAS 137592-45-1 - Calbiochem A potent, cell permeable, reversible, ATP-competitive and selective inhibitor of protein kinase C (IC₅₀ = 13 nM). C₂₇H₂₆N₄O₂
203293 InSolution™ Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem C₂₅H₂₄N₄O₂
203297-M Bisindolylmaleimide IV - CAS 119139-23-0 - Calbiochem A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM). C₂₀H₁₃N₃O₂
203303 Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM). C₂₁H₁₅N₃O₂
208725 Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem A cell permeable, highly specific inhibitor of protein kinase C (IC₅₀ = 50 nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. C₄₄H₃₈O₁₄
220285 Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem Naturally-occurring alkaloid. C₂₁H₁₈NO₄Cl
324683 Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. C₁₄H₆O₈ · 2H₂O
365250 Gö 6976 - CAS 136194-77-9 - Calbiochem Gö 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC₅₀ = 7.9 nM for rat brain). Exhibits selectively for PKCα (IC₅₀ = 2.3 nM) and βI (IC₅₀ = 6.2 nM). C₂₄H₁₈N₄O
365251 Gö 6983 - CAS 133053-19-7 - Calbiochem Gö 6983, CAS 133053-19-7, is a potent, cell-permeable, reversible, and ATP-competitive inhibitor of several PKC isozymes (IC50 = 7 nM for PKCα & β; 6 nM for PKCγ; 10 nM for PKCδ; & 60 nM for PKCζ)., A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes. C₂₆H₂₆N₄O₃
365252 Gö 7874, Hydrochloride - CAS 287935-76-6 - Calbiochem A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC₅₀ = 4 nM for rat brain PKC). C₂₇H₂₆N₄O₄ · HCl
365253 InSolution™ Gö 6976 - CAS 136194-77-9 - Calbiochem C₂₄H₁₈N₄O
371955-M H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem A broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor. C₁₄H₁₇N₃O₂S · 2HCl
372770 HBDDE - CAS 154675-18-0 - Calbiochem A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKCα and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays. C₁₆H₁₈O₈
377980 Hispidin - CAS 555-55-5 - Calbiochem A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC₅₀ = 2 µM). C₁₃H₁₀O₅
400076-M Hypericin - CAS 548-04-9 - Calbiochem Polycyclic dione that has anti-retroviral activity. C₃₀H₁₆O₈
420297 InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem C₂₇H₂₁N₃O₅
420298-M K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem K-252a, Nocardiopsis sp., CAS 97161-97-2, is a cell-permeable, ATP-competitive inhibitor of multiple protein kinases (Ki = 1.8, 20, 18, 25, 20, 3 nM for CaMKII, MLCK, PKA, PKC, PKG & 140 trk)., A cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases. C₂₇H₂₁N₃O₅
420305 K-252c - CAS 85753-43-1 - Calbiochem A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (IC₅₀ = 2.45 µM) and protein kinase A (IC₅₀ = 25.7 µM). C₂₀H₁₃N₃O
444605 Melittin - CAS 37231-28-0 - Calbiochem A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner. C₁₃₁H₂₂₉N₃₉O₃₁
476475 PKC Inhibitor, EGF-R Fragment 651-658, Myristoylated - Calbiochem The PKC Inhibitor, EGF-R Fragment 651-658, Myristoylated controls the biological activity of PKC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. C₆₀H₁₁₇N₂₁O₁₁
476480 PKC 20-28, Cell-Permeable, Myristoylated - Calbiochem Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ). C₆₀H₁₀₆N₁₈O₁₁
524488 Phloretin - CAS 60-82-2 - Calbiochem A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM). C₁₅H₁₄O₅
527948 Piceatannol - CAS 10083-24-6 - Calbiochem A cell-permeable, substrate competitive and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC₅₀ = 3 µM), PKC (IC₅₀ = 8 µM), MLCK (IC₅₀ = 12 µM). C₁₄H₁₂O₄
5.30993 PKCε Translocation Inhibitor II, PKCe141 - Calbiochem A cell-permeable inhibitor of PKCε-RACK2 interaction (IC₅₀ = 5.9 µM). C₂₂H₁₇N₃O₄S
539522 PKCε Translocation Inhibitor Peptide - Calbiochem The PKCε Translocation Inhibitor Peptide, Negative Control controls the biological activity of PKCε. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. C₃₇H₆₅N₉O₁₃
539542 PKCε Translocation Inhibitor Peptide, Negative Control - Calbiochem The PKCε Translocation Inhibitor Peptide, Negative Control controls the biological activity of PKCε. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. C₃₇H₆₅N₉O₁₃
539560   PKC Inhibitor Peptide 19-36 The PKC Inhibitor Peptide 19-36 controls the biological activity of PKC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. C₉₃H₁₅₉N₃₅O₂₄
539604 PKCη Pseudosubstrate Inhibitor, Myristoylated - Calbiochem The PKCη Pseudosubstrate Inhibitor, Myristoylated controls the biological activity of PKCη. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. C₁₀₁H₁₈₅N₄₁O₂₃S
539610 PKCζ/ι Pseudosubstrate Inhibitor - Calbiochem The PKCζ/ι Pseudosubstrate Inhibitor controls the biological activity of PKCζ/ι. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. C₇₆H₁₂₈N₃₀O₁₆
539636 PKCθ Pseudosubstrate Inhibitor, Myristoylated - Calbiochem The PKCθ Pseudosubstrate Inhibitor, Myristoylated controls the biological activity of PKCθ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. C₁₀₅H₁₈₂N₃₅O₂₂S
539644 UCN-01 A cell-permeable Staurosporine derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases. C₂₈H₂₆N₄O₄
539649 PKCθ/δ Inhibitor C₂₂H₁₈N₄O₂
539652 PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem The PKCβII/EGFR Inhibitor, also referenced under CAS 145915-60-2, controls the biological activity of PKCβII/EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. C₂₀H₁₃F₂N₃O₂
539654 PKCβ Inhibitor - CAS 257879-35-9 - Calbiochem The PKCβ Inhibitor, also referenced under CAS 257879-35-9, controls the biological activity of PKCβ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. C₂₄H₂₁N₅O₂
557370 Rottlerin - CAS 82-08-6 - Calbiochem Rottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ (IC50 = 3-6 µM) & PKCθ. Has about 10-fold lower potency against other isozymes., A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC₅₀ = 3-6 µM) and PKCθ. C₃₀H₂₈O₈
557508 Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC₅₀ = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. C₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2O
557514 Ro-31-8425 - CAS 131848-97-0 - Calbiochem A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC₅₀ = 15 nM for rat brain PKC). C₂₆H₂₄N₄O₂ · HCl
557520 Ro-31-8220 - CAS 138489-18-6 - Calbiochem A cell-permeable, reversible, competitive, and selective inhibitor of protein kinase C (PKC; IC₅₀ = 10 nM) over CaM kinase II (IC₅₀ = 17 µM) and protein kinase A (IC₅₀ = 900 nM). C₂₅H₂₃N₅O₂S · CH₄O₃S
557521 InSolution™ Ro-31-8220 - Calbiochem C₂₅H₂₃N₅O₂S • CH₃SO₃H
557525 Ro-32-0432 - CAS 145333-02-4 - Calbiochem A selective cell-permeable protein kinase C inhibitor. C₂₈H₂₈N₄O₂ · HCl
559300 Safingol - CAS 15639-50-6 - Calbiochem A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. C₁₈H₃₉NO₂
559307 Sangivamycin - CAS 18417-89-5 - Calbiochem C₁₂H₁₅N₅O₅
569397 Staurosporine, Streptomyces sp. Staurosporine, CAS 62996-74-, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinases (IC₅₀ = 7, 20, 1.3, 0.7, & 8.5 nM for PKA, CAMK, MLCK, PKC, & PKG, respectively). C₂₈H₂₆N₄O₃
579000 Tamoxifen Citrate - CAS 54965-24-1 - Calbiochem Tamoxifen is a potent synthetic anti-estrogenic agent. C₂₆H₂₉NO · C₆H₈O₇
579002 Tamoxifen, 4-Hydroxy-, (Z)- - CAS 68047-06-3 - Calbiochem Tamoxifen, 4-Hydroxy-, (Z), CAS 68047-06-3, is a cell-permeable, active metabolite of Tamoxifen that is more potent than the parent compound and inhibits PKC by modifying its catalytic domain., A cell-permeable, active metabolite of Tamoxifen that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain. C₂₆H₂₉NO₂
B3056 Bisindolylmaleimide II ≥97% (Mixture of 2 isomers) C27H26N4O2
B3306 Bisindolylmaleimide IV ≥98% (TLC), solid C20H13N3O2
B3681 Bisindolylmaleimide VII 96% (TLC), solid C27H27N5O2
B3931 Bisindolylmaleimide X hydrochloride ≥90%, solid C26H24N4O2 · HCl
C6303 Calphostin C from Cladosporium cladosporioides ≥90% (HPLC), powder C44H38O14
C2932 Chelerythrine chloride ≥95% (TLC), powder C21H18ClNO4
D3314 D-erythro-Dihydrosphingosine ≥98% C18H39NO2
B6292 GF 109203X hydrochloride ≥95% C25H24N4O2 · HCl
I7016 H-7 dihydrochloride ≥98% (HPLC) C14H17N3O2S · 2HCl
H5257 Hispidin solid, ≥98% (HPLC) C13H10O5
K1388 KT 5823 ≥85% (HPLC), lyophilized powder C29H25N3O5
M2272 Melittin from honey bee venom ≥85% (HPLC) C131H229N39O31
M7795 rac-2-Methoxy-3-hexadecanamido-1-propylphosphocholine ≥90% C25H53N2O6P
I2764 ML-7 powder C15H17IN2O2S · HCl
C1172 ML-9 ≥99% (TLC), powder C15H17ClN2O2S · HCl
M6760 Myricetin ≥96.0%, crystalline C15H10O8
P4509 Palmitoyl-DL-carnitine chloride powder C23H46ClNO4
P3115   Protein Kinase C Inhibitor, Myristoylated ≥7.5 mg/mL (peptide and counter ion), ≥95% (Minimum peptide content 70%, HPLC), aqueous solution (neutral pH)  
R5648 Rottlerin C30H28O8
S7049 D-Sphingosine synthetic C18H37NO2
S4400 Staurosporine from Streptomyces sp. ≥98% (HPLC), film C28H26N4O3
T7254 Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride ≥96% (TLC), powder C14H21ClN2O3S · HCl