Zinc Probes

Zinc is the second most abundant transition metal (after iron) in living organisms. Many zinc-dependent enzymes and transcription factors are known. Its central role in cellular processes such as gene expression, apoptosis, enzyme regulation and neurotransmission suggests that Zn2+ is a major regulatory ion in cell metabolism.

However, compared to other cations like Ca2+, Na+, K+, relatively little is known about the cellular regulation of Zn2+. Most of the Zn2+ abundant in eukaryotes is tightly bound. With respect of the cellular regulation of Zn2+, the "free" (chelatable) Zn2+ is of special interest. "Free" Zn2+ is found in relatively high concentrations in the brain, pancreas and spermatozoa. Several tools for measuring chelatable Zn2+ in living cells have been established to clarify its physiological significance. Similar to the well-established probes for intracellular Ca2+ such as Fura-2, a range of fluorogenic Zn2+-probes have been developed. Newer probes can be excited in the visible range to avoid cell damage and high background fluorescence.

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N1040 N1-(7-Nitro-2,1,3-benzoxadiazol-4-yl)-N1,N2,N2-tris(2-pyridinylmethyl)-1,2-ethanediamine for fluorescence
Z2251 Zinquin ethyl ester ≥95% (HPLC), solid
76663 ZnAF-1 ≥95.0% (HPCE)
67975 ZnAF-2 ≥95.0% (HPCE)
90917 ZnAF-1F ≥90% (HPCE)
90916 ZnAF-2F ≥95.0% (HPCE)
89997 ZnAF-1 DA BioReagent, ~90% (HPCE)
90911 ZnAF-2 DA ~90% (HPCE)