Dextrans

Dextrans are polysaccharides with molecular weights ≥1000 Dalton, which have a linear backbone of α-linked D-glucopyranosyl repeating units. Three classes of dextrans can be differentiated by their structural features:

  • Class 1 dextrans contain the α(1→6)-linked D-glucopyranosyl backbone modified with small side chains of D-glucose branches with α(1→2), α(1→3), and α(1→4)-linkage. The class 1 dextrans vary in their molecular weight, spatial arrangement, type and degree of branching, and length of branch chains, depending on the microbial producing strains and cultivation conditions. Isomaltose and isomaltotriose are oligosaccharides with the class 1 dextran backbone structure.
  • Class 2 dextrans (alternans) contain a backbone structure of alternating α(1→3) and α(1→6)-linked D-glucopyranosyl units with α(1→3)-linked branches.
  • Class 3 dextrans (mutans) have a backbone structure of consecutive α(1→3)-linked D-glucopyranosyl units with α(1→6)-linked branches. One and two-dimensional NMR spectroscopy techniques have been utilized for the structural analysis of dextrans.

The physical and chemical properties of purified dextrans vary depending on the microbial strains from which they are produced and by the production method. Dextrans have high water solubility and the solutions behave as Newtonian fluids. Solution viscosity depends on concentration, temperature, and molecular weight, which have a characteristic distribution. The hydroxyl groups present in dextran offer many sites for derivatization, and these functionalized glycoconjugates represent a largely unexplored class of biocompatible and environmentally safe compounds.

Sigma Life Sciences offers a large variety of dextrans with high polydispersity and dextran molecular weight standards with low polydispersity (Mw/Mn values close to 1.0). Dextran sulfate from Leuconostoc spp. and fluorophore-dextran conjugates are also available in a range of polymer sizes.

Dextrans for General Research Applications

Product #

Description

CAS Number

Molecular Weight

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31387 Dextran from Leuconostoc spp. Mr 15,000-25,000 9004-54-0 Mr 15,000-25,000
31392 Dextran from Leuconostoc spp. Mr 450,000-650,000 9004-54-0 Mr 450,000-650,000
09184 Dextran from Leuconostoc spp. Mr ~100,000 9004-54-0 Mr ~100,000
31398 Dextran from Leuconostoc mesenteroides Mr ~200,000 9004-54-0 Mr ~200,000
31389 Dextran from Leuconostoc spp. Mr ~40,000 9004-54-0 Mr ~40,000
68084 Dextran from Leuconostoc spp. Mr ~40000 9004-54-0 Mr ~40000
31388 Dextran from Leuconostoc spp. Mr ~6,000 9004-54-0 Mr ~6,000
31397 Dextran from Leuconostoc mesenteroides Mr ~60,000 9004-54-0 Mr ~60,000
31390 Dextran from Leuconostoc spp. Mr ~70,000 9004-54-0 Mr ~70,000
44886 Dextran from Leuconostoc spp. Mr ~70000 9004-54-0 Mr ~70000
D5376 Dextran from Leuconostoc mesenteroides average mol wt 1,500,000-2,800,000 9004-54-0 average mol wt 1,500,000-2,800,000
90475 Blue Dextran average mol wt 10,000 87915-38-6 average mol wt 10,000
00898 DEAE-Dextran average mol wt 10,000 9015-73-0 average mol wt 10,000
04482 DEAE-Dextran average mol wt 150,000 9015-73-0 average mol wt 150,000
D4876 Dextran from Leuconostoc mesenteroides average mol wt 150,000 9004-54-0 average mol wt 150,000
44369 Q-Dextran average mol wt 150,000   average mol wt 150,000
03714 Blue Dextran average mol wt 20,000 87915-38-6 average mol wt 20,000
78816 DEAE-Dextran average mol wt 20,000 9015-73-0 average mol wt 20,000
05858 Q-Dextran average mol wt 20,000   average mol wt 20,000
D1662 Dextran from Leuconostoc mesenteroides average mol wt 35,000-45,000 9004-54-0 average mol wt 35,000-45,000
19534 Q-Dextran average mol wt 4,000   average mol wt 4,000
80881 DEAE-Dextran average mol wt 40,000 9015-73-0 average mol wt 40,000
97316 Phenyl-Dextran average mol wt 40,000   average mol wt 40,000
D3759 Dextran from Leuconostoc mesenteroides average mol wt 48,000-90,000 9004-54-0 average mol wt 48,000-90,000
90008 Blue Dextran average mol wt 5,000 87915-38-6 average mol wt 5,000
93556 DEAE-Dextran average mol wt 500,000 9015-73-0 average mol wt 500,000
77027 DEAE-Dextran average mol wt 70,000 9015-73-0 average mol wt 70,000
19068 Q-Dextran average mol wt 70,000   average mol wt 70,000
D9260 Dextran from Leuconostoc mesenteroides average mol wt 9,000-11,000 9004-54-0 average mol wt 9,000-11,000

Dextran Standards for Gel Permeation Chromatography (GPC)

Product #

Description

CAS Number

Molecular Weight

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31416 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 1,000 9004-54-0 Mn ~1,000
Mp ~1,100
Mw ~1,300
00268 Dextran analytical standard, for GPC, 1,000 9004-54-0 Mn ~1,010
Mp ~1,080
Mw ~1,270
31422 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 150,000 9004-54-0 Mn ~100,000
Mp ~125,000
Mw ~150,000
00893 Dextran analytical standard, for GPC, 150,000 9004-54-0 Mn ~100,300
Mp ~123,600
Mw ~147,600
00894 Dextran analytical standard, for GPC, 270,000 9004-54-0 Mn ~164200
Mp ~196,300
Mw ~273,000
31423 Dextran from Leuconostoc mesenteroides for GPC, Mw 270,000 9004-54-0 Mn ~165,000
Mp ~195,000
Mw ~270,000
00271 Dextran analytical standard, for GPC, 25,000 9004-54-0 Mn ~18,300
Mp ~21,400
Mw ~23,800
31419 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 25,000 9004-54-0 Mn ~20,000
Mp ~20,000
Mw ~25,000
31424 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 410,000 9004-54-0 Mn ~235,000
Mp ~275,000
Mw ~410,000
00895 Dextran analytical standard, for GPC, 410,000 9004-54-0 Mn ~236,300
Mp ~276,500
Mw ~409,800
00269 Dextran analytical standard, for GPC, 5,000 9004-54-0 Mn ~3,260
Mp ~4,440
Mw ~5,220
31417 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 5,000 9004-54-0 Mn ~3,300
Mp ~4,400
Mw ~5,200
31425 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 670,000 9004-54-0 Mn ~330,000
Mp ~400,000
Mw ~670,000
00896 Dextran analytical standard, for GPC, 670,000 9004-54-0 Mn ~332,800
Mp ~401,300
Mw ~667,800
31420 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 50,000 9004-54-0 Mn ~35,000
Mp ~45,000
Mw ~50,000
00891 Dextran analytical standard, for GPC, 50,000 9004-54-0 Mn ~35,600
Mp ~43,500
Mw ~48,600
31421 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 80,000 9004-54-0 Mn ~55,000
Mp ~65,000
Mw ~80,000
00892 Dextran analytical standard, for GPC, 80,000 9004-54-0 Mn ~55,500
Mp ~66,700
Mw ~80,900
31418 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 12,000 9004-54-0 Mn ~8,000
Mp ~10,000
Mw ~12,000
00270 Dextran analytical standard, for GPC, 12,000 9004-54-0 Mn ~8,110
Mp ~9,890
Mw ~11,600
31394 Dextran enzymatic synth. 9004-54-0 Mr ~1,500

Dextran Sulfates for General Research Applications

Product #

Description

CAS Number

Molecular Weight

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31404 Dextran sulfate sodium salt from Leuconostoc spp. Mr 5,000 9011-18-1 Mr 5,000
51227 Dextran sulfate sodium salt Mr ~15,000   Mr ~15,000
68841 Dextran sulfate sodium salt from Leuconostoc spp. Mr ~20,000 9011-18-1 Mr ~20,000
67578 Dextran sulfate sodium salt   Mr ~200,000
42867 Dextran sulfate sodium salt Mr ~40,000   Mr ~40,000
52423 Dextran sulfate sodium salt from Leuconostoc spp. low sulfate content, Mr ~40,000 9011-18-1 Mr ~40,000
75027 Dextran sulfate sodium salt   Mr ~4000
68076 Dextran sulfate sodium salt from Leuconostoc spp. low sulfate content, Mw 3000-6000 9011-18-1 Mw 3000-6000
RES2029D-A7 Dextran sulfate sodium salt PharmaGrade, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production.   Mw 8000 g/mol
38739 Dextran sulfate sodium salt from Leuconostoc spp. low sulfate content 9011-18-1 Mw ~10,000
40357 Dextran sulfate sodium salt from Leuconostoc spp. low sulfate content 9011-18-1 Mw ~20,000
D8906 Dextran sulfate sodium salt from Leuconostoc spp. for molecular biology, average Mw >500,000 (dextran starting material), contains 0.5-2% phosphate buffer 9011-18-1 average Mw >500,000 (dextran starting material)
D6001 Dextran sulfate sodium salt from Leuconostoc spp. average mol wt >500,000 (dextran starting material), contains 0.5-2.0% phosphate buffer, pH 6-8 9011-18-1 average mol wt >500,000 (dextran starting material)
D6924 Dextran sulfate sodium salt from Leuconostoc spp. average mol wt 9,000-20,000 9011-18-1 average mol wt 9,000-20,000
D4911 Dextran sulfate sodium salt from Leuconostoc spp. mol wt 6,500-10,000 9011-18-1 mol wt 6,500-10,000

CM-Dextran and Fluorescein Isothiocyanate (FITC) Conjugates

Product #

Description

CAS Number

Molecular Weight

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74817 FITC-CM-Dextran average mol wt 150,000   average mol wt 150,000
68059 FITC-CM-Dextran average mol wt 4,000   average mol wt 4,000
53379 FITC-CM-Dextran average mol wt 40,000   average mol wt 40,000
53471 FITC-CM-Dextran average mol wt 70,000   average mol wt 70,000
86524 CM-Dextran sodium salt BioXtra 39422-83-8  

Fluorescent Dye-Dextran Conjugates

Product #

Description

CAS Number

Molecular Weight

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90718 Fluorescein isothiocyanate–dextran average Mw 70,000 60842-46-8 average Mw 70,000
FD10S Fluorescein isothiocyanate–dextran average mol wt 10,000 60842-46-8 average mol wt 10,000
74817 FITC-CM-Dextran average mol wt 150,000   average mol wt 150,000
69658 Fluorescein isothiocyanate–dextran average mol wt 150,000 60842-46-8 average mol wt 150,000
FD2000S Fluorescein isothiocyanate–dextran average mol wt 2,000,000 60842-46-8 average mol wt 2,000,000
52471 Fluorescein isothiocyanate–dextran average mol wt 2,000,000 60842-46-8 average mol wt 2,000,000
95648 FITC–DEAE–Dextran average mol wt 20,000   average mol wt 20,000
FD20S Fluorescein isothiocyanate–dextran average mol wt 20,000 60842-46-8 average mol wt 20,000
73766 Tetramethylrhodamine isothiocyanate–Dextran average mol wt 20,000   average mol wt 20,000
FD4 Fluorescein isothiocyanate–dextran average mol wt 3,000-5,000 60842-46-8 average mol wt 3,000-5,000
53379 FITC-CM-Dextran average mol wt 40,000   average mol wt 40,000
01649 FITC–DEAE–Dextran average mol wt 40,000   average mol wt 40,000
FD40S Fluorescein isothiocyanate–dextran average mol wt 40,000 60842-46-8 average mol wt 40,000
FD40 Fluorescein isothiocyanate–dextran average mol wt 40,000 60842-46-8 average mol wt 40,000
42874 Tetramethylrhodamine isothiocyanate–Dextran average mol wt 40,000   average mol wt 40,000
52194 Tetramethylrhodamine isothiocyanate–Dextran average mol wt 500,000   average mol wt 500,000
53471 FITC-CM-Dextran average mol wt 70,000   average mol wt 70,000
54702 FITC–DEAE–Dextran average mol wt 70,000   average mol wt 70,000
46945 Fluorescein isothiocyanate–dextran average mol wt 70,000, (FITC:Glucose = 1:250) 60842-46-8 average mol wt 70,000
46947 Fluorescein isothiocyanate – Dextran 500000-Conjugate (FITC:Glucose = 1:100)    

Fluoroscein Isothiocyanate (FITC)-DEAE-Dextran Conjugates

Product #

Description

CAS Number

Molecular Weight

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75005 FITC–DEAE–Dextran average mol wt 150,000   average mol wt 150,000
95648 FITC–DEAE–Dextran average mol wt 20,000   average mol wt 20,000
01649 FITC–DEAE–Dextran average mol wt 40,000   average mol wt 40,000
54702 FITC–DEAE–Dextran average mol wt 70,000   average mol wt 70,000