Quality research using BioPerformance Certified Products

Quality research needs quality products. Below you find a short list of BioPerformance Certified products used in various research applications.

 

Tris T6066

Bhargava A., Anant M., Mack H.
Reproducibility Project Cancer Biology.
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, were selected on the basis of citations and Altmetric scores (Errington et al., 2014). This Registered Report describes the proposed replication plan...Read more
Amin N.A., Balasubramanian S., Saiya-Cork K., Shedden K., Hu N., Malek S.N.
Clin Cancer Res. 2017 Feb 15;23(4):1049-1059
Purpose: Ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, is approved for the treatment of relapsed chronic lymphocytic leukemia (CLL) and CLL with del17p. Mechanistically, ibrutinib interferes with B-cell receptor (BCR) signaling as well as multiple CLL cell-to-microenvironment interactions. Given the importance of ibrutinib in the management of CLL, a deeper understanding of factors governing sensitivity and resistance is warranted...Read More
 
de Oliveira G.C., Kanamori K.S., Auxiliadora-Martins M., Chini C.C.S., Chini E.N.
Bio Protoc. 2018 Jul 20;8(14).
CD38 is a multifunctional enzyme involved in calcium signaling and Nicotinamide Adenine Dinucleotide (NAD+) metabolism. Through its major activity, the hydrolysis of NAD+, CD38 helps maintain the appropriate levels of this molecule for all NAD+-dependent metabolic processes to occur. Due to current advances and studies relating NAD+ decline and the development of multiple age-related conditions and diseases, CD38 gained importance in both basic science...Read More
van der Pluijm I., Burger J., van Heijningen P.M., IJpma A., van Vliet N., Milanese C2. Schoonderwoerd K., Sluiter W., Ringuette L.J., Dekkers D.H.W., Que I., Kaijzel E.L., Te Riet L., MacFarlane E.G., Das D., van der Linden R., Vermeij M., Demmers J.A., Mastroberardino P.G., Davis E.C., Yanagisawa H., Dietz H.C., Kanaar R., Essers J.
Cardiovasc Res. 2018 Nov 1;114(13):1776-1793
AIM: Thoracic aortic aneurysms are a life-threatening condition often diagnosed too late. To discover novel robust biomarkers, we aimed to better understand the molecular mechanisms underlying aneurysm formation....Read More
Sarikhani M., Mishra S., Maity S., Kotyada C., Wolfgeher D., Gupta M.P., Singh M., Sundaresan NR.
Elife. 2018 Mar 5;7. pii: e32952. doi: 10.7554/eLife.32952.
Glycogen synthase kinase 3 (GSK3) is a critical regulator of diverse cellular functions involved in the maintenance of structure and function. Enzymatic activity of GSK3 is inhibited by N-terminal serine phosphorylation. However, alternate post-translational mechanism(s) responsible for GSK3 inactivation are not characterized. Here, we report that GSK3α and GSK3β are acetylated at Lys246 and Lys183, respectively...Read More

 

 

Trizma Hydrochloride (T5941)

Berndt N., Sebti S.M.
Nat Protoc. 2011 Oct 27;6(11):1775-91. doi: 10.1038/nprot.2011.387.
The importance of the post-translational lipid modifications farnesylation and geranylgeranylation in protein localization and function coupled with the critical role of prenylated proteins in malignant transformation has prompted interest in their biology and the development of farnesyl transferase and geranylgeranyl transferase inhibitors (FTIs and GGTIs) as chemical probes and anticancer agents...Read more
Khedr M.A., Massarotti A., Mohamed M.E.
Sci Rep. 2018 Jun 4;8(1):8565. doi: 10.1038/s41598-018-26998-x.
Fungal infections are spreading widely worldwide, and the types of treatment are limited due to the lack of diverse therapeutic agents and their associated side effects and toxicity. The discovery of new antifungal classes is vital and critical. We discovered the antifungal activity of abscisic acid through a rational drug design methodology that included...Read More
 
Ma Z., Wang H., Cai Y., Wang H., Niu K., Wu X., Ma H., Yang Y., Tong W., Liu F., Liu Z., Zhang Y., Liu R., Zhu Z.J., Liu N.
Elife. 2018 May 29;7. pii: e35368. doi: 10.7554/eLife.35368.
Epigenetic alteration has been implicated in aging. However, the mechanism by which epigenetic change impacts aging remains to be understood. H3K27me3, a highly conserved histone modification signifying transcriptional repression, is marked and maintained by Polycomb Repressive Complexes (PRCs). Here, we explore the mechanism...Read More

 

 

PBS (P5368)

Parra-Acero H., Ros-Rocher N., Perez-Posada A., Kożyczkowska A., Sánchez-Pons N., Nakata A., Suga H., Najle S.R., Ruiz-Trillo I.
Development. 2018 May 23;145(10). pii: dev162107. doi: 10.1242/dev.162107.
How animals emerged from their unicellular ancestor remains a major evolutionary question. New genome data from the closest unicellular relatives of animals have provided important insights into the evolution of animal multicellularity. We know that the unicellular ancestor of animals had an unexpectedly complex genetic repertoire, including...Read more
Cotney J.L., Noonan J.P.
Cold Spring Harb Protoc. 2015 Apr 1;2015(4):419. doi: 10.1101/pdb.err087585.
Chromatin immunoprecipitation with fixed animal tissues and preparation for high-throughput sequencing....Read More
 
Sawada T., Arai D., Jing X., Miyajima M., Frank S.J., Sakaguchi K.
PLoS One. 2017 Jul 7;12(7):e0180785. doi: 10.1371/journal.pone.0180785. eCollection 2017.
We previously reported that EphA4, a member of the Eph family of receptor tyrosine kinases, is an important modulator of growth hormone (GH) signaling, leading to augmented synthesis of insulin-like growth factor 1 (IGF1) for postnatal body growth. In the present study, we report the molecular interactions of EphA4, GH receptor (GHR), Janus kinase 2 (JAK2), and signal transducer...Read More
Grindstaff J.L., Merrill L.
J Exp Zool A Ecol Integr Physiol. 2017 Jun;327(5):262-272. doi: 10.1002/jez.2086.
Developmental conditions may impact the expression of immune traits throughout an individual's life. Early-life challenges may lead to immunological constraints that are mediated by endocrine-immune interactions. In particular, individual differences in the ability to mount immune responses may be programmed by exposure to stressors...Read more
Martinez N.E., Sharp J.L., Johnson T.E., Kuhne W.W., Stafford C.T., Duff M.C.
Sensors (Basel). 2018 Aug 21;18(9). pii: E2750. doi: 10.3390/s18092750.
This study considers whether a relationship exists between response to lithium (Li) exposure and select vegetation indices (VI) determined from reflectance spectra in each of four plant species: Arabidopsis thaliana, Helianthus annuus (sunflower), Brassica napus (rape), and Zea mays (corn). Reflectance spectra were collected every week for three weeks...Read more

 

 

HEPES (H3784)

Song Y., Xu Y., Liang M., Zhang Y., Chen M., Deng J., Li Z.
Biosci Rep. 2018 Mar 21;38(2). pii: BSR20171490. doi: 10.1042/BSR20171490. Print 2018 Apr 27.
Hermaphroditism is a rare disorder that affects sexual development, resulting in individuals with both male and female sexual organs. Hermaphroditism is caused by anomalies in genes regulating sex determination, gonad development, or expression of hormones and their receptors during embryonic development during sexual differentiation. SRY is a sex-determination gene...Read more
Rutkowska A., Sailer A.W., Dev K.K.
J Neuroinflammation. 2017 Dec 16;14(1):250. doi: 10.1186/s12974-017-1025-0.
BACKGROUND: The G protein-coupled receptor EBI2 (Epstein-Barr virus-induced gene 2) is activated by 7α, 25-dihydroxycholesterol (7α25HC) and plays a role in T cell-dependant antibody response and B cell migration....Read More
 
Okuda K., Silverman N.
Bio Protoc. 2017 Dec 5;7(23). pii: e2640. doi: 10.21769/BioProtoc.2640.
This protocol describes how to generate and harvest antibody-free L. amazonensis amastigotes, and how to infect adult Drosophila melanogaster with these parasites...Read More

 

 

MES (M2933)

Madison M.N., Welch J.L., Okeoma C.M.
Bio Protoc. 2017 Apr 5;7(7). pii: e2216. doi: 10.21769/BioProtoc.2216.
Exosomes are membranous extracellular nanovesicles of endocytic origin. Exosomes are known to carry host and pathogen-derived genomic, proteomic, lipidomic cargos and other extraneous molecules. Exosomes are secreted by diverse cell types into the extracellular milieu and are subsequently internalized...Read more
Wang C., Zhang J., Schroeder J.I.
Bio Protoc. 2017 Jan 20;7(2). pii: 2114. doi: 10.21769/BioProtoc.2114.
Two-Electrode Voltage-Clamp (TEVC) recording in Xenopus laevis oocytes provides a powerful method to investigate the functions and regulation of ion channel proteins. This approach provides a well-known tool to characterize ion channels or transporters expressed in Xenopus laevis oocytes. The plasma membrane of the oocyte...Read More
 
Wierzba M.P., Tax F.E.
Genetics. 2016 Feb;202(2):689-702. doi: 10.1534/genetics.115.180380. Epub 2015 Dec 17.
Receptor-like kinases (RLKs) mediate cell-signaling pathways in Arabidopsis thaliana, including those controlling growth and development, immune response, and cell death. The RLK coreceptor BRI1-ASSOCIATED KINASE-1 (BAK1) partners with multiple ligand-binding RLKs and contributes to their signaling in diverse pathways...Read More
Macri C., Wang F., Tasset I., Schall N., Page N., Briand J.P., Cuervo A.M., Muller S.
Autophagy. 2015;11(3):472-86. doi: 10.1080/15548627.2015.1017179.
The P140 peptide, a 21-mer linear peptide (sequence 131-151) generated from the spliceosomal SNRNP70/U1-70K protein, contains a phosphoserine residue at position 140. It significantly ameliorates clinical manifestations in autoimmune patients with systemic lupus erythematosus and enhances survival in MRL/lpr lupus-prone mice. Previous studies showed...Read More
Sarikhani M., Mishra S., Maity S., Kotyada C., Wolfgeher D., Gupta M.P., Singh M., Sundaresan NR.
Elife. 2018 Mar 5;7. pii: e32952. doi: 10.7554/eLife.32952.
Glycogen synthase kinase 3 (GSK3) is a critical regulator of diverse cellular functions involved in the maintenance of structure and function. Enzymatic activity of GSK3 is inhibited by N-terminal serine phosphorylation. However, alternate post-translational mechanism(s) responsible for GSK3 inactivation are not characterized. Here, we report that GSK3α and GSK3β are acetylated at Lys246 and Lys183, respectively...Read More

 

 

Water (W3513)

Hewitt S.N., Choi R., Kelley A., Crowther G.J., Napuli A.J., Van Voorhis W.C.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1006-9. doi: 10.1107/S1744309111022159. Epub 2011 Aug 13
Despite recent advances, the expression of heterologous proteins in Escherichia coli for crystallization remains a nontrivial challenge. The present study investigates the efficacy of maltose-binding protein (MBP) fusion as a general strategy for rescuing the expression of target proteins. From a group of sequence-verified clones...Read more

 

 

Sodium Phosphate Monobasic (S5011)

Liu J., Zhu Y., Luo G.Z., Wang X., Yue Y., Wang X., Zong X., Chen K., Yin H., Fu Y., Han D., Wang Y., Chen D., He C..
Nat Commun. 2016 Oct 7;7:13052. doi: 10.1038/ncomms13052.
DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression...Read more
Valtcheva M.V., Copits B.A., Davidson S., Sheahan T.D., Pullen M.Y., McCall J.G., Dikranian K., Gereau R.W. 4th.
Nat Protoc. 2016 Oct;11(10):1877-88. doi: 10.1038/nprot.2016.111. Epub 2016 Sep 8.
Primary cultures of rodent sensory neurons are widely used to investigate the cellular and molecular mechanisms involved in pain, itch, nerve injury and regeneration. However, translation of these preclinical findings may be greatly improved by direct validation in human tissues. We have developed an approach to extract and culture human sensory neurons...Read More
 
Bayley R., Ahmed F., Glen K., McCall M., Stacey A., Thomas R.
J Tissue Eng Regen Med. 2018 Jan;12(1):e368-e378. doi: 10.1002/term.2337. Epub 2017 Apr 3.
Manufacture of red blood cells (RBCs) from progenitors has been proposed as a method to reduce reliance on donors. Such a process would need to be extremely efficient for economic viability given a relatively low value product and high (2 × 1012 ) cell dose. Therefore, the aim of these studies was to define the productivity of an industry standard...Read More
Strand J., Ragborg M.M., Pedersen H.S., Kristensen T.N., Pertoldi C., Callesen H.
Conserv Physiol. 2016 Dec 29;4(1):cow069. doi: 10.1093/conphys/cow069. eCollection 2016
The aim of this study was to establish and validate a reliable and efficient protocol for the recovery and cryopreservation of epididymal spermatozoa used for in vitro fertilization, using bulls of two different age classes. Testicles from 26 (37-51 weeks old, group 1) and 19 (52-115 weeks old, group 2) Danish Holstein bulls were collected after...Read More
Sachweh M.C., Stafford W.C., Drummond C.J., McCarthy A.R., Higgins M., Campbell J., Brodin B., Arnér E.S., Laín S.
Oncotarget. 2015 Jun 30;6(18):16488-506.
Malignant melanoma is the most dangerous type of skin cancer. Although recent progress in treatment has been achieved, lack of response, drug resistance and relapse remain major problems. The tumor suppressor p53 is rarely mutated in melanoma, yet it is inactive in the majority of cases due to dysregulation of upstream pathways...Read More
Gatliff J., East D., Crosby J., Abeti R., Harvey R., Craigen W., Parker P., Campanella M.
Autophagy. 2014;10(12):2279-96. doi: 10.4161/15548627.2014.991665.
The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ubiquitination of proteins. TSPO abolishes mitochondrial relocation...Read More
Liu Y., Liu H., Sauvey C., Yao L., Zarnowska E.D., Zhang S.C.
Nat Protoc. 2013 Sep;8(9):1670-9. doi: 10.1038/nprot.2013.106. Epub 2013 Aug 8.
Forebrain γ-aminobutyric acid (GABA) interneurons have crucial roles in high-order brain function via modulating network activities and plasticity, and they are implicated in many psychiatric disorders. Availability of enriched functional human forebrain GABA interneurons, especially those from people affected by GABA interneuron...Read More
Marrus S.B., Cuculich P.S., Wang W., Nerbonne J.M.
Channels (Austin). 2011 Nov-Dec;5(6):500-9. doi: 10.4161/chan.5.6.18524. Epub 2011 Nov 1.
Andersen-Tawil syndrome is characterized by periodic paralysis, ventricular ectopy, and dysmorphic features. Approximately 60% of patients exhibit loss-of-function mutations in KCNJ2, which encodes the inwardly rectifying K(+) channel pore forming subunit Kir2.1. Here, we report the identification of a novel KCNJ2 mutation...Read More

 

 

PIPES (P1851)

Guillamat P., Kos Ž., Hardoüin J., Ignés-Mullol J., Ravnik M., Sagués F.
Sci Adv. 2018 Apr 6;4(4):eaao1470. doi: 10.1126/sciadv.aao1470. eCollection 2018 Apr.
The formation of emulsions from multiple immiscible fluids is governed by classical concepts such as surface tension, differential chemical affinity and viscosity, and the action of surface-active agents. Much less is known about emulsification when one of the components is active and thus inherently not constrained by the laws...Read more
Guillamat P., Ignés-Mullol J., Sagués F.
Nat Commun. 2017 Sep 15;8(1):564. doi: 10.1038/s41467-017-00617-1.
Active matter embraces systems that self-organize at different length and time scales, often exhibiting turbulent flows apparently deprived of spatiotemporal coherence. Here, we use a layer of a tubulin-based active gel to demonstrate that the geometry of active flows is determined by a single length scale, which we reveal in the...Read More
 
Forment J.V., Jackson S.P.
Nat Protoc. 2015 Sep;10(9):1297-307. doi: 10.1038/nprot.2015.066. Epub 2015 Jul 30.
Protein accumulation on chromatin has traditionally been studied using immunofluorescence microscopy or biochemical cellular fractionation followed by western immunoblot analysis. As a way to improve the reproducibility of this kind of analysis, to make it easier to quantify and to allow a streamlined application in high-throughput screens, we recently...Read More
Winter M., Wait E., Roysam B., Goderie S.K., Ali R.A., Kokovay E., Temple S., Cohen A.R.
Nat Protoc. 2011 Nov 17;6(12):1942-52. doi: 10.1038/nprot.2011.422.
This protocol and the accompanying software program called LEVER (lineage editing and validation) enable quantitative automated analysis of phase-contrast time-lapse images of cultured neural stem cells. Images are captured at 5-min intervals over a period of 5-15 d as the cells proliferate and differentiate...Read More
Rossi A.M., Taylor C.W.
Elife. 2018 Mar 5;7. pii: e32952. doi: 10.7554/eLife.32952.
Quantification of the associations between biomolecules is required both to predict and understand the interactions that underpin all biological activity. Fluorescence polarization (FP) provides a nondisruptive means of measuring the association of a fluorescent ligand with a larger molecule. We describe an FP assay in which binding...Read More

 

 

BES (B4554)

Arden E., Metzger J.M.
J Biol Methods. 2016;3(2). pii: e38. Epub 2016 May 3.
Recombinant adeno-associated virus (AAV) is a valuable and often used gene therapy vector. With increased demand for highly purified virus comes the need for a standardized purification procedure that is applicable across many serotypes and includes bioengineered viruses. Currently cesium chloride banding or affinity chromatography are the predominate forms ...Read more
Radu C.G., Cheng D., Nijagal A., Riedinger M., McLaughlin J., Yang L.V., Johnson J., Witte O.N.
Mol Cell Biol. 2006 Jan;26(2):668-77.
T-cell death-associated gene 8 (TDAG8) is a G-protein-coupled receptor transcriptionally upregulated by glucocorticoids (GCs) and implicated by overexpression studies in psychosine-mediated inhibition of cytokinesis and in GC-induced apoptosis. To examine the physiological function of TDAG8, we generated knockout (KO) mice by...Read More
 
Shah V.B., Aiken C.
Bio Protoc. 2013 Oct 20;3(20). pii: e949.
This is a protocol to detect HIV-1 reverse transcription products in cytoplasmic and nuclear fractions of cells infected with VSV-G-pseudotyped envelope-defective HIV-1. This protocol can also be extended to HIV-1 with regular envelope...Read More

 

 

Bis-Tris Propane (B4679)

Zhou J., Tan S.H., Nicolas V., Bauvy C., Yang N.D., Zhang J., Xue Y., Codogno P., Shen H.M.
Cell Res. 2013 Apr;23(4):508-23. doi: 10.1038/cr.2013.11. Epub 2013 Jan 22.
Lysosome is a key subcellular organelle in the execution of the autophagic process and at present little is known whether lysosomal function is controlled in the process of autophagy. In this study, we first found that suppression of mammalian target of rapamycin (mTOR) activity by starvation or two mTOR catalytic inhibitors (PP242 and Torin1), but not...Read more

 

 

Sodium Chloride (S6191)

Roy S., Yang G., Tang Y., Scott D.A.
Nat Protoc. 2011 Dec 15;7(1):62-8. doi: 10.1038/nprot.2011.428.
We describe a strategy for analyzing axonal transport of cytosolic proteins (CPs) using photoactivatable GFP-PAGFP-with modifications of standard imaging components that can be retroactively fitted to a conventional epifluorescence microscope. The photoactivation and visualization are nearly simultaneous, allowing studies of proteins...Read more
Xu T., Johnson C.A., Gestwicki J.E., Kumar A.
Nat Protoc. 2010 Nov;5(11):1831-43. doi: 10.1038/nprot.2010.141. Epub 2010 Oct 28.
We present here a protocol to conditionally control the nuclear trafficking of target proteins in yeast. In this system, rapamycin is used to heterodimerize two chimeric proteins. One chimera consists of a FK506-binding protein (FKBP12) fused to a cellular 'address' (nuclear localization signal or nuclear export sequence). The second chimera consists...Read More
 
Villén J., Gygi S.P.
Nat Protoc. 2008;3(10):1630-8. doi: 10.1038/nprot.2008.150.
The success in profiling the phosphoproteome by mass spectrometry-based proteomics has been intimately related to the availability of methods that selectively enrich for phosphopeptides. To this end, we describe a protocol that combines two sequential enrichment steps. First, strong cation exchange (SCX) chromatography separates peptides...Read More
Cappelle J., Duong V., Pring L., Kong L., Yakovleff M., Prasetyo D.B., Peng B., Choeung R., Duboz R., Ong S., Sorn S., Dussart P., Tarantola A., Buchy P., Chevalier V.
PLoS Negl Trop Dis. 2016 Dec 7;10(12):e0005149. doi: 10.1371/journal.pntd.0005149. eCollection 2016 Dec.
Despite the increased use of vaccination in several Asian countries, Japanese Encephalitis (JE) remains the most important cause of viral encephalitis in Asia in humans with an estimated 68,000 cases annually. Considered a rural disease occurring mainly in paddy-field dominated landscapes where pigs are amplifying hosts, JE may nevertheless circulate...Read More
Zlitni A., Yin M2, Janzen N., Chatterjee S., Lisok A., Gabrielson K.L., Nimmagadda S., Pomper M.G., Foster F.S., Valliant J.F.
PLoS One. 2017 May 4;12(5):e0176958. doi: 10.1371/journal.pone.0176958. eCollection 2017.
Prostate specific membrane antigen (PSMA) targeted microbubbles (MBs) were developed using bioorthogonal chemistry. Streptavidin-labeled MBs were treated with a biotinylated tetrazine (MBTz) and targeted to PSMA expressing cells using trans-cyclooctene (TCO)-functionalized anti-PSMA antibodies (TCO-anti-PSMA). The extent of...Read More
van den Hurk M., Erwin J.A., Yeo G.W., Gage F.H., Bardy C.
Front Mol Neurosci. 2018 Aug 10;11:261. doi: 10.3389/fnmol.2018.00261. eCollection 2018.
The human brain is composed of a complex assembly of about 171 billion heterogeneous cellular units (86 billion neurons and 85 billion non-neuronal glia cells). A comprehensive description of brain cells is necessary to understand the nervous system in health and disease. Recently, advances in genomics have permitted the accurate analysis...Read More
Liu Y., Liu H., Sauvey C., Yao L., Zarnowska E.D., Zhang S.C.
Nat Protoc. 2013 Sep;8(9):1670-9. doi: 10.1038/nprot.2013.106. Epub 2013 Aug 8.
Forebrain γ-aminobutyric acid (GABA) interneurons have crucial roles in high-order brain function via modulating network activities and plasticity, and they are implicated in many psychiatric disorders. Availability of enriched functional human forebrain GABA interneurons, especially those from people affected by GABA interneuron...Read More
Kettenbach A.N., Rush J., Gerber S.A.
Nat Protoc. 2011 Feb;6(2):175-86. doi: 10.1038/nprot.2010.196. Epub 2011 Jan 27.
In the analysis of biological systems, it is of interest to identify the components of the system and to monitor their changes in abundance under different conditions. The AQUA (for 'absolute quantification') method allows sensitive and specific targeted quantification of protein and post-translational modifications in complex protein mixtures using stable isotope-labeled peptides...Read More

 

 

DMSO (D2438)

Stec W., Rosiak K., Treda C., Smolarz M., Peciak J., Pacholczyk M., Lenart A., Grzela D., Stoczynska-Fidelus E.,2, Rieske P.
Oncotarget. 2018 Jan 6;9(9):8560-8572. doi: 10.18632/oncotarget.24058. eCollection 2018 Feb 2.
Despite intensive research no therapies targeted against the oncogenic EGFRvIII are present in the clinic. One of the reasons is the elusive nature of the molecular structure and activity of the truncated receptor. The recent publications indicate the EGF-bound wild-type EGFR to trans-phosphorylate the EGFRvIII initiating aberrant signaling cascade...Read more
She A., Kurtser I., Reis S.A., Hennig K., Lai J., Lang A., Zhao W.N., Mazitschek R., Dickerson B.C., Herz J., Haggarty S.J.
Cell Chem Biol. 2017 Jul 20;24(7):892-906.e5. doi: 10.1016/j.chembiol.2017.06.010. Epub 2017 Jul 14.
Frontotemporal dementia (FTD) arises from neurodegeneration in the frontal, insular, and anterior temporal lobes. Autosomal dominant causes of FTD include heterozygous mutations in the GRN gene causing haploinsufficiency of progranulin (PGRN) protein. Recently, histone deacetylase (HDAC) inhibitors have been identified as enhancers of PGRN expression...Read More
 
Kabacik S., Raj K.
Oncotarget. 2017 May 30;8(47):82049-82063. doi: 10.18632/oncotarget.18282. eCollection 2017 Oct 10.
The association between ionising radiation (IR) exposure and risk of cardiovascular diseases (CVD) is well documented, but the underlying mechanism is still poorly understood. As atherosclerotic plaques are the most common cause of CVD, we investigated the effects of IR on one of the critical parameters for atherosclerotic plaque formation...Read More