Antibodies to Nicotinic Acetylcholine Receptors

Nicotine is a chemical with multiple biological and neurological actions. It is a natural alkaloid that mimics the effects of acetylcholine as a neurotransmitter. Nicotinic acetylcholine receptors are cholinergic receptors that activate ligand-gated ion channels in the plasma membranes of certain neurons and muscle cells. These ion channels are opened by the binding of nicotine. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors, being found throughout the nervous system and in the neuromuscular junctions of somatic muscles. When the channel opens, positively-charged sodium ions enter the cell and positively-charged potassium ions exit for a net positive increase inside the cell. Research suggests that nicotinic acetylcholine receptors may have a role in cognitive performance, as well as affecting mood, reducing pain sensitivity, and enhancing the release of other neurotransmitters. Sigma-Aldrich offers antibodies that have agonist and antagonist effects on nicotinic acetylcholine receptors.

Product #

Description

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Form

Gene Symbol (ID)

Species Reactivity

Application

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AV34909 Anti-CHRNA1 (AB1) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNA1(1134)
human
WB
AV34910 Anti-CHRNA1 (AB2) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNA1(1134)
rabbit, human, mouse, horse, dog, bovine, guinea pig, rat
WB
HPA029430 Anti-CHRNA3 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNA3(1136)
human
IHC
WH0001137M1 Monoclonal Anti-CHRNA4 antibody produced in mouse 4E3, monoclonal
purified immunoglobulin
human ... CHRNA4(1137)
human
ELISA (i), WB
SAB2500237 Anti-CHRNA4 (AA 29-43) antibody produced in goat polyclonal
affinity isolated antibody
human ... CHRNA4(1137)
human, canine, mouse, bovine, rat
ELISA (i), WB
SAB2100424 Anti-CHRNA4 (ab1) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNA4(1137)
bovine, human
WB
SAB2100425 Anti-CHRNA4 (ab2) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNA4(1137)
human, rat, mouse, guinea pig
WB
AV34967 Anti-CHRNA5 antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... CHRNA5(1138)
human, horse, bovine, guinea pig, dog, rat, mouse
WB
WH0001138M1 Monoclonal Anti-CHRNA5 antibody produced in mouse 7D3, monoclonal
purified immunoglobulin
human ... CHRNA5(1138)
human
ELISA (i), WB
AV13018 Anti-CHRNA7 (AB2) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... CHRNA7(1139)
rat, bovine, mouse, human
WB
HPA005822 Anti-CHRNB1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNB1(1140)
human
IHC
WH0001140M1 Monoclonal Anti-CHRNB1 antibody produced in mouse 4G4, monoclonal
purified immunoglobulin
human ... CHRNB1(1140)
human
ELISA (i), WB
SAB2500238 Anti-CHRNB1/ACHRB antibody produced in goat polyclonal
affinity isolated antibody
human ... CHRNB1(1140)
bovine, rat, mouse, human
ELISA (i), WB
AV13020 Anti-CHRNB2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNB2(1141)
mouse, dog, pig, bovine, human
WB
AV37669 Anti-CHRNB2 (AB1) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... CHRNB2(1141)
pig, human
WB
WH0001145M1 Monoclonal Anti-CHRNE antibody produced in mouse 6A2, monoclonal
purified immunoglobulin
human ... CHRNE(1145)
human
ELISA (i), WB
SAB2100426 Anti-CHRNG antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNG(1146)
dog, rabbit, human
WB
AV13024 Anti-CHRNG, N-terminal region antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... CHRNG(1146)
human, dog, rabbit
WB
N7783 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1 Subunit) antibody produced in rat mAb 142, monoclonal
purified immunoglobulin
  Torpedo (only)
IHC (p)
M221 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α3 Subunit) antibody produced in rat mAb 313, monoclonal
affinity isolated antibody
chicken ... CHRNA3(386578)
chicken
IHC (f)
M218 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α4 Subunit) antibody produced in rat mAb 299, monoclonal
purified immunoglobulin
human ... CHRNA4(1137)
rat ... Chrna4(25590)
human, rat, chicken
IHC (f), RIA
M220 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α7 Subunit) antibody produced in mouse mAb 306, monoclonal
purified immunoglobulin
human ... CHRNA7(1139)
rat ... Chrna7(25302)
human (denatured), rat (denatured), chicken
IHC (f)
M217 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1, α3, α5 Subunits) antibody produced in rat mAb 35, monoclonal
purified immunoglobulin
human ... CHRNA1(1134), CHRNA3(1136), CHRNA5(1138)
eel, chicken, human
IHC (f)