Antibodies to Nicotinic Acetylcholine Receptors

Nicotine is a chemical with multiple biological and neurological actions. It is a natural alkaloid that mimics the effects of acetylcholine as a neurotransmitter. Nicotinic acetylcholine receptors are cholinergic receptors that activate ligand-gated ion channels in the plasma membranes of certain neurons and muscle cells. These ion channels are opened by the binding of nicotine. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors, being found throughout the nervous system and in the neuromuscular junctions of somatic muscles. When the channel opens, positively-charged sodium ions enter the cell and positively-charged potassium ions exit for a net positive increase inside the cell. Research suggests that nicotinic acetylcholine receptors may have a role in cognitive performance, as well as affecting mood, reducing pain sensitivity, and enhancing the release of other neurotransmitters. Sigma-Aldrich offers antibodies that have agonist and antagonist effects on nicotinic acetylcholine receptors.

Product #

Description

Clone

Form

Gene Symbol (ID)

Species Reactivity

Application

Add to Cart

AV34909 Anti-CHRNA1 (AB1) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNA1(1134)
rabbit, mouse, bovine, guinea pig, canine, human, horse
WB
AV34910 Anti-CHRNA1 (AB2) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNA1(1134)
canine, horse, bovine, rabbit, human, rat, mouse, guinea pig
WB
HPA029430 Anti-CHRNA3 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNA3(1136)
human
IHC
AV13014 Anti-CHRNA3 (AB1) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNA3(1136)
canine, human, mouse, bovine, rat
WB
AV13024 Anti-CHRNA3 (AB2) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... CHRNA3(1136)
human, guinea pig, rabbit, bovine, canine, mouse
WB
WH0001137M1 Monoclonal Anti-CHRNA4 antibody produced in mouse 4E3, monoclonal
purified immunoglobulin
human ... CHRNA4(1137)
human
ELISA (i), WB
SAB2500237 Anti-CHRNA4 (AA 29-43) antibody produced in goat polyclonal
affinity isolated antibody
human ... CHRNA4(1137)
bovine, mouse, canine, human, rat
ELISA (i), WB
SAB2100424 Anti-CHRNA4 (ab1) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNA4(1137)
rabbit, human, bovine, guinea pig, mouse, rat
WB
SAB2100425 Anti-CHRNA4 (ab2) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNA4(1137)
bovine, rat, mouse, rabbit, human, zebrafish, guinea pig, canine, horse
WB
AV34967 Anti-CHRNA5 antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... CHRNA5(1138)
guinea pig, rabbit, zebrafish, canine, bovine, mouse, horse, rat, human
WB
WH0001138M1 Monoclonal Anti-CHRNA5 antibody produced in mouse 7D3, monoclonal
purified immunoglobulin
human ... CHRNA5(1138)
human
ELISA (i), WB
AV13018 Anti-CHRNA7 (AB2) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... CHRNA7(1139)
bovine, mouse, rat, human
WB
HPA005822 Anti-CHRNB1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNB1(1140)
human
IHC
WH0001140M1 Monoclonal Anti-CHRNB1 antibody produced in mouse 4G4, monoclonal
purified immunoglobulin
human ... CHRNB1(1140)
human
ELISA (i), WB
SAB2500238 Anti-CHRNB1/ACHRB antibody produced in goat polyclonal
affinity isolated antibody
human ... CHRNB1(1140)
rat, bovine, mouse, human
ELISA (i), WB
AV13020 Anti-CHRNB2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNB2(1141)
mouse, zebrafish, canine, bovine, pig, human
WB
AV37669 Anti-CHRNB2 (AB1) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... CHRNB2(1141)
pig, rat, human, bovine, mouse, guinea pig
WB
AV13023 Anti-CHRNE antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... CHRNE(1145)
guinea pig, rat, pig, mouse
WB
WH0001145M1 Monoclonal Anti-CHRNE antibody produced in mouse 6A2, monoclonal
purified immunoglobulin
human ... CHRNE(1145)
human
ELISA (i), WB
SAB2100426 Anti-CHRNG antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CHRNG(1146)
guinea pig, rabbit, human, rat, canine, mouse, bovine
WB
N7658 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1 Subunit) antibody produced in rat mAb 61, monoclonal
purified immunoglobulin
human ... CHRNA1(1134)
mouse ... Chrna1(11435)
mouse, human
IHC (p), WB
N7783 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1 Subunit) antibody produced in rat mAb 142, monoclonal
purified immunoglobulin
  Torpedo (only)
IHC (p)
N8283 Monoclonal Anti-Nicotinic Acetylcholine Receptor (β1 Subunit) antibody produced in rat mAb 111, monoclonal
purified immunoglobulin
human ... CHRNB1(1140)
mouse ... Acp5(11433)
rat ... Chrnb1(24261)
rat, mouse, eel, human
IHC (p), IP, WB
N8533 Monoclonal Anti-Nicotinic Acetylcholine Receptor (β2 Subunit) antibody produced in rat mAb 290, monoclonal
purified immunoglobulin
human ... CHRNB2(1141)
mouse ... Chrnb2(11444)
rat ... Chrnb2(54239)
chicken, rat, mouse, human
IHC, IHC (p), IP
M221 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α3 Subunit) antibody produced in rat mAb 313, monoclonal
affinity isolated antibody
chicken ... CHRNA3(386578)
chicken
IHC (f)
M218 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α4 Subunit) antibody produced in rat mAb 299, monoclonal
purified immunoglobulin
human ... CHRNA4(1137)
rat ... Chrna4(25590)
rat, chicken, human
IHC (f), RIA
N7908 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α5 Subunit) antibody produced in rat mAb 268, monoclonal
purified immunoglobulin
human ... CHRNA5(1138)
human, chicken
IHC (p), WB
M220 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α7 Subunit) antibody produced in mouse mAb 306, monoclonal
purified immunoglobulin
human ... CHRNA7(1139)
rat ... Chrna7(25302)
human (denatured), rat (denatured), chicken
IHC (f)
N8783 Monoclonal Anti-Nicotinic Acetylcholine Receptor (δ Subunit) antibody produced in rat mAb 166, monoclonal
purified immunoglobulin
  amphibian, Torpedo
IHC (p), WB
M217 Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1, α3, α5 Subunits) antibody produced in rat mAb 35, monoclonal
purified immunoglobulin
human ... CHRNA1(1134), CHRNA3(1136), CHRNA5(1138)
eel, human, chicken
IHC (f)